Compare Zyrtec vs. prednisolone acetate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyrtec (Cetirizine)

Prescription or OTC
Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Calms down redness and swelling in the eye.

Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects.

Upsides
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
  • Omnipred (prednisolone acetate) works only within the eye, so it will relieve symptoms without having the side effects of oral steroids.
  • Kicks in relatively quickly to relieve symptoms.
  • Available in generic form.
Downsides
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
  • Depending on the condition, you might have to use Omnipred (prednisolone acetate) up to 4 times a day, particularly in the beginning.
  • If using Omnipred (prednisolone acetate) long-term, may require some monitoring by your doctor.
  • Contains sulfite, so depending on the severity of your allergy, may not be suitable for those with allergies to sulfite.
  • Long-term use can lead to increased risk of more serious side effects.
Used for
  • Inflammation of the Eye
  • Eye Injury
  • Allergies
Dosage forms
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
  • Liquid
Price
No pricing information available
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Reviews
1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

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Side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
The Omnipred (prednisolone acetate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Taking the wrong medication
  • Increased side effects
    • Age 65 or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Overdosage
    • Current kidney disease
    • Current liver disease
See more detailed risks and warnings
  • Glaucoma and cataracts
  • Increased risk of infection
  • Thinning of eye layer
  • Severe allergic reactions
    • Asthma
See more detailed risks and warnings