Compare Zyrtec vs. Prednisolone Acetate

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Pred Forte
(Prednisolone Acetate)

Treats allergy symptoms. Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.Coming soon.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Zyrtec (Cetirizine)
of people (All ages) say Zyrtec (Cetirizine) is worth it
say it works well
say it's a big hassle
1232 reviews
Have you used Zyrtec (Cetirizine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Pred Forte (Prednisolone Acetate)?
Worth itNot sureNot worth it
Side effects
ZyrtecPrednisolone Acetate

We haven’t found good data for Zyrtec side effects.

FDA side effect reports for Zyrtec »

We haven’t found good data for Prednisolone Acetate side effects.

FDA side effect reports for Prednisolone Acetate »
How it works
ZyrtecPrednisolone Acetate
Zyrtec (Cetirizine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. Antihistamines can also make you sleepy, but Zyrtec is a low-drowsiness version.Coming soon.
Type of medication
ZyrtecPrednisolone Acetate
Prescription or OTC
Available as
ZyrtecPrednisolone Acetate
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
  • Liquid
Used for
ZyrtecPrednisolone Acetate
  • Inflammation
Risk factors for serious side effects
ZyrtecPrednisolone Acetate
    • Age 65 or older
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Current kidney disease
    • Current liver disease
    Detailed Zyrtec (Cetirizine) risks & warnings »
    Coming soon.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    ZyrtecPrednisolone Acetate
    • People with kidney or liver disease may need to take a lower dose of Zyrtec (Cetirizine) to prevent overdose. Talk with your doctor to be sure you are using the correct dose.
    No kidneys and liver related info.
    ZyrtecPrednisolone Acetate
    • Can make you feel sleepy, so take it at bedtime if needed.
    No sleep related info.
    Upsides and benefits
    ZyrtecPrednisolone Acetate
    • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
    • Works well to also treat hives and itchy skin.
    • Zyrtec (Cetirizine) is available over the counter without a prescription.
    • It comes as a tablet, liquid, and quick-dissolving tablet.
    • It can provide quick relief of allergy symptoms for both kids and adults.
    • It's okay to take with most other medications because it has few drug interactions.
    • Most people don't get any side effects from Zyrtec (Cetirizine).
    Coming soon
    Downsides and risks
    ZyrtecPrednisolone Acetate
    • Although it works fast, its effectiveness wears off for some people over time.
    • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
    • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
    • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
    Coming soon
    Tips from our pharmacists for people taking the medication
    ZyrtecPrednisolone Acetate
    • Starts working in a few hours. Only take it once a day.
    • Can make you feel sleepy, so take it at bedtime if needed.
    • Avoid some of the side effects by drinking plenty of non-caffeinated liquids.
    • If you need to use it for more than a few weeks, talk with your doctor about trying a nasal steroid instead since it might work better for you long-term.
    • Using an antihistamine eye drop instead can also work better to treat itchy or watery eyes.
    Coming soon
    Learn more
    More about ZyrtecSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zyrtec (Cetirizine)?
    Worth itNot sureNot worth it
    More about Prednisolone AcetateSide effectsReviews & ratingsFDA package insert
    Have you used Pred Forte (Prednisolone Acetate)?
    Worth itNot sureNot worth it