Compare Zyrtec vs. Zyrtec D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Relieves congestion and allergy symptoms.

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

3.7/ 5 average rating with 927 reviewsforZyrtec D
Upsides
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
Downsides
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
Used for
Dosage forms
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
  • Extended release
No pricing information available
No pricing information available
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Reviews
1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

Have you used Zyrtec (Cetirizine)?

Leave a review
927 reviews so far
75%
saidit'sworth it
43%
saiditworked well
9%
saidit'sa big hassle

Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?

Leave a review
Side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
The Zyrtec D (Cetirizine / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Taking the wrong medication
  • Increased side effects
    • Age 65 or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Overdosage
    • Current kidney disease
    • Current liver disease
See more detailed risks and warnings
  • High blood pressure
    • History of high blood pressure
  • Heart problems
    • History of heart problems
    • Age 65 or older
  • Seizure
    • History of seizure
  • Harm to fetus
    • Women of childbearing age
  • Taking the wrong medication
  • Increased side effects
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Overdosage
    • Current kidney disease
    • Current liver disease
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.