Compare Zyvox vs. Flagyl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyvox (linezolid)

Prescription only

Flagyl (metronidazole)

Prescription only
Treats bacterial infections.

Zyvox (linezolid) is good first-choice treatment for serious infections caused by gram positive bacteria.

Treats and prevents bacterial infections.

Flagyl (metronidazole) is very good at treating certain bacterial infections, but you can't have any alcohol while on it since it'll make you throw up a lot.

Upsides
  • Zyvox (linezolid) is effective at treating serious infections caused by certain types of bacteria.
  • Zyvox (linezolid) can be taken orally in liquid form or injected if you have trouble swallowing pills.
  • Flagyl (metronidazole) is good at killing a variety of bacteria.
  • Unlike many other antibiotics, Flagyl (metronidazole) is less likely to make bacteria resistant to it.
  • Most forms are available as a generic, so it's relatively cheap.
Downsides
  • Zyvox (linezolid) can cause dangerously high blood pressures when combined with certain depression medications or excessive amounts of cheese or alcohol.
  • You can't drink alcohol while on Flagyl (metronidazole), and for at least 3 days after you finish it.
  • Side effects can include nausea, headache, stomach upset, and a metallic taste in your mouth.
  • If you're taking Flagyl (metronidazole) for a long time, there's a risk of more side effects, such as nerve damage.
  • If you're on blood thinners, let your doctor know. Flagyl (metronidazole) can interact with your medicines and make you more likely to bleed.
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
  • Extended-release pill
  • Injection
Price
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Reviews
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Side effects
9possible side effects
  • Diarrhea
    8%
  • Nausea
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Dizziness
    2%
  • Rash
    2%
  • Anemia
    2%
  • Fungal infection of the mouth
    2%
  • Abnormal liver function
    2%
See more detailed side effects
13possible side effects
  • Headache
    18%
  • Nausea
    10%
  • Metallic taste
    9%
  • Genital itching
    5%
  • Dizziness
    4%
  • Diarrhea
    4%
  • Stomach problems
    4%
  • Overgrowth of yeast
    3%
  • Stuffy nose
    3%
  • Menstrual cramps
    3%
  • Abnormal urine
    3%
  • Dry mouth
    2%
  • Urinary tract infection
    2%
See more detailed side effects
Risks and risk factors
  • Blood and bone marrow problems
    • Taking Zyvox (linezolid) for longer than 2 weeks
    • Existing bone marrow disease
    • Use of other medicines that affect the bone marrow suppression
    • Chronic infection
    • Use of other antibiotic therapies
  • Nerve and eye damage
  • Serotonin syndrome
    • Taking drugs for depression, migraines, or pain
  • Infectious diarrhea
    • Taking Zyvox (linezolid) for a long time
  • Acid buildup in the blood (lactic acidosis)
  • Low blood sugar
    • Diabetes
    • Using insulin or other diabetic medications
See more detailed risks and warnings
  • Seizure or brain problems
    • Taking high doses of Flagyl (metronidazole)
    • Taking Flagyl (metronidazole) for a long time
  • Nerve damage
    • Taking high doses of Flagyl (metronidazole)
    • Taking Flagyl (metronidazole) for a long time
  • Cancer
  • New infection while taking Flagyl (metronidazole)
    • Taking Flagyl (metronidazole) incorrectly
  • Interaction with alcohol
    • Drinking alcohol while taking Flagyl (metronidazole)
See more detailed risks and warnings