Mental health disorders

Depression

(Major depression)

  • Also known as
  • Clinicial depression
  • Major depressive disorder
  • MDD

About Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Symptoms of Depression
  • Sadness
  • Loss of interest or pleasure in activities you used to enjoy
  • Weight gain or loss
  • Difficulty sleeping or oversleeping
  • Energy loss
  • Feelings of worthlessness
  • Thoughts of death or suicide

Top Medications for Depression according to our users

Filter group. All currently selected

All Medications for Depression

  • Abilify
    (aripiprazole)
    Prescription only

    Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
    • Liquid
    • Injection
  • amoxapine
    Prescription only

    While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

    • Available dosage forms:
    • Pill
  • Celexa
    (citalopram)
    Prescription only

    Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.

    • Available dosage forms:
    • Pill
    • Oral solution
  • Cymbalta
    (duloxetine)
    Prescription only

    Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.

    • Available dosage forms:
    • Extended release
  • desipramine
    Prescription only

    Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • Effexor
    (venlafaxine)
    Prescription only

    Effexor (Venlafaxine) is good for treating depression and anxiety. It may work when other antidepressants haven't, but it's more likely to cause side effects and withdrawal symptoms than other antidepressants.

    • Available dosage forms:
    • Pill
    • Extended release
  • Elavil
    (amitriptyline)
    Prescription only

    Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.

    • Available dosage forms:
    • Pill
  • Lexapro
    (escitalopram)
    Prescription only

    Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.

    • Available dosage forms:
    • Pill
    • Liquid
  • maprotiline
    Prescription only

    While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • nefazodone
    Prescription only

    Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • Oleptro
    (trazodone)
    Prescription only

    Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.

    • Available dosage forms:
    • Pill
    • Extended release
  • Pamelor
    (nortriptyline)
    Prescription only

    Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

    Was it worth it?
    Men
    Not enough review data. Review it!
    Women
    Not enough review data. Review it!
    • Available dosage forms:
    • Pill
    • Liquid
  • Paxil
    (paroxetine)
    Prescription only

    Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.

    • Available dosage forms:
    • Pill
    • Extended release tablet
    • Liquid
  • phenelzine
    Prescription only

    Nardil (phenelzine) is not a first choice for treating depression, but it can be good if other medicines haven't worked. It can interact with a lot of medicines, and you have to avoid certain foods and alcohol.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • Pristiq
    (desvenlafaxine)
    Prescription only

    Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

    • Available dosage forms:
    • Extended release
  • Prozac
    (fluoxetine)
    Prescription only

    Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

    • Available dosage forms:
    • Pill
    • Delayed release capsule
    • Liquid
  • Remeron
    (mirtazapine)
    Prescription only

    Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
  • Seroquel
    (quetiapine)
    Prescription only

    Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.

    • Available dosage forms:
    • Pill
    • Extended release
  • Surmontil
    (trimipramine)
    Prescription only

    Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

    • Available dosage forms:
    • Pill
  • Tofranil-PM
    (imipramine pamoate)
    Prescription only

    Tofranil-PM (imipramine pamoate) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • Tofranil
    (imipramine hydrochloride)
    Prescription only

    Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

    • Available dosage forms:
    • Pill
  • tranylcypromine
    Prescription only

    Parnate (tranylcypromine) is not a first choice medicine to treat depression because of its side effects and interactions with other medicines and foods.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
  • Trintellix (Vortioxetine) is a new type of serotonin modulating antidepressant that can be tried when the other antidepressants don't work, but some people may find the side effects intolerable and the cost expensive.

    Was it worth it?
    Men
    Not enough review data. Review it!
    Women
    Not enough review data. Review it!
    • Available dosage forms:
    • Pill
    • Available dosage forms:
    • Pill
  • Wellbutrin
    (bupropion)
    Prescription only

    Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

    • Available dosage forms:
    • Pill
    • Extended release
  • Zoloft
    (sertraline)
    Prescription only

    Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.

    • Available dosage forms:
    • Pill
    • Liquid
  • Zyprexa
    (olanzapine)
    Prescription only

    Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
    • Injection
  • Anafranil
    (clomipramine)
    Prescription only

    Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

    • Available dosage forms:
    • Pill
  • Buspar
    (buspirone)
    Prescription only

    Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.

    • Available dosage forms:
    • Pill
  • Dexedrine
    (dextroamphetamine)
    Prescription only

    Dexedrine (Dextroamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.

    Was it worth it?
    Men
    Not enough review data. Review it!
    Women
    Not enough review data. Review it!
    • Available dosage forms:
    • Pill
    • Extended release
    • Liquid
  • fluvoxamine
    Prescription only

    Luvox CR (fluvoxamine) is a first choice treatment for obsessive-compulsive disorder, but it can lower your sex drive.

    Was it worth it?Review it
    • Available dosage forms:
    • Pill
    • Extended release
  • Mirapex
    (pramipexole)
    Prescription only

    Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

    • Available dosage forms:
    • Pill
    • Extended release
  • Provigil
    (modafinil)
    Prescription only

    Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.

    Was it worth it?
    Men
    Not enough review data. Review it!
    Women
    73%
    • Available dosage forms:
    • Pill
  • Tegretol
    (carbamazepine)
    Prescription only

    Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.

    • Available dosage forms:
    • Pill
    • Extended release
    • Chewable tablet
    • Oral suspension
    • Available dosage forms:
    • Pill
    • Patch
  • Viibryd
    (vilazodone)
    Prescription only

    Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

    • Available dosage forms:
    • Pill
  • Lamictal
    (lamotrigine)
    Prescription only

    Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

    • Available dosage forms:
    • Pill
    • Extended release
    • Chewable tablet
    • Dissolving tablet

Medication side effects for Depression

These are some of the most common side effects from clinical trials for Constipation.

  • Lexapro: 3%
  • maprotiline: 9%
  • Zoloft: 15%
  • Zyprexa: 26%
0 of 100

At this end, no one is expected to have Constipation

100 of 100

At this end, almost everyone is expected to have Constipation

Tips, success stories, and coping strategies for Depression

What tip would you give someone like me who was just diagnosed?
  • don't try to live in the past, it'll kill you
  • Be patient, it may take some time to get relief
  • Keep your mind focused on the how to get better for the future
What’s your best coping strategy?
  • Take it slow
  • Know you will have good and bad days it's ok
  • Meditation helps me calm the mind and think with ration
Besides medications, what else has worked for you?
  • Sleeping and exercising!
  • Intellectual stimulation (e.g. reading)
  • Caffeine