Mental health disorders

Depression

(Major depression)

  • Also known as
  • Clinicial depression
  • Major depressive disorder
  • MDD

About Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Symptoms of Depression
  • Sadness
  • Loss of interest or pleasure in activities you used to enjoy
  • Weight gain or loss
  • Difficulty sleeping or oversleeping
  • Energy loss
  • Feelings of worthlessness
  • Thoughts of death or suicide

Top Medications for Depression according to our users

Filter group. All currently selected

All Medications for Depression

  • Abilify
    (aripiprazole)
    Prescription only

    Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It's less likely to cause side effects than other antipsychotics.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
    • Liquid
    • Injection
  • amoxapine
    Prescription only

    While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

    • Available dosage forms:
    • Pill
  • Celexa
    (citalopram)
    Prescription only

    Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems.

    • Available dosage forms:
    • Pill
    • Liquid
  • Cymbalta
    (duloxetine)
    Prescription only

    Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

    • Available dosage forms:
    • Pill
    • Extended release
  • desipramine
    Prescription only

    Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

    • Available dosage forms:
    • Pill
  • Effexor
    (venlafaxine)
    Prescription only

    Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.

    • Available dosage forms:
    • Pill
    • Extended release
  • Elavil
    (amitriptyline)
    Prescription only

    Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.

    • Available dosage forms:
    • Pill
  • Fetzima
    (levomilnacipran)
    Prescription only

    Fetzima (Levomilnacipran) may be effective in treating depression. It can be expensive because it's only available as a brand name.

    • Available dosage forms:
    • Extended release
  • Lexapro
    (escitalopram)
    Prescription only

    Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.

    • Available dosage forms:
    • Pill
    • Liquid
  • maprotiline
    Prescription only

    While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

    • Available dosage forms:
    • Pill
  • Marplan
    (isocarboxazid)
    Prescription only

    Marplan (isocarboxazid) is an antidepressant that only recommended if other medications haven't worked.

    • Available dosage forms:
    • Pill
  • nefazodone
    Prescription only

    Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

    • Available dosage forms:
    • Pill
  • Oleptro
    (trazodone)
    Prescription only

    Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.

    • Available dosage forms:
    • Pill
    • Extended release
  • Pamelor
    (nortriptyline)
    Prescription only

    Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

    • Available dosage forms:
    • Pill
    • Liquid
  • Paxil
    (paroxetine)
    Prescription only

    Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

    • Available dosage forms:
    • Pill
    • Extended release pill
    • Liquid
  • phenelzine
    Prescription only

    Nardil (phenelzine) is not a first choice for treating depression, but it can be good if other medicines haven't worked. It can interact with a lot of medicines, and you have to avoid certain foods and alcohol.

    • Available dosage forms:
    • Pill
  • Pristiq
    (desvenlafaxine)
    Prescription only

    Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

    • Available dosage forms:
    • Extended release
  • Prozac
    (fluoxetine)
    Prescription only

    Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

    • Available dosage forms:
    • Pill
    • Delayed-release pill
    • Liquid
  • Remeron
    (mirtazapine)
    Prescription only

    Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
  • Rexulti
    (brexpiprazole)
    Prescription only

    Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.

    • Available dosage forms:
    • Pill
  • Seroquel
    (quetiapine)
    Prescription only

    Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

    • Available dosage forms:
    • Pill
    • Extended release
  • Surmontil
    (trimipramine)
    Prescription only

    Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

    • Available dosage forms:
    • Pill
  • Symbyax
    (olanzapine / fluoxetine)
    Prescription only

    Symbyax (olanzapine / fluoxetine) is recommended for people who have bipolar disorder with depression, but you're likely to have issues with weight gain and blood sugar.

    • Available dosage forms:
    • Pill
  • Tofranil-PM
    (imipramine pamoate)
    Prescription only

    Tofranil-PM (imipramine pamoate) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

    • Available dosage forms:
    • Pill
  • Tofranil
    (imipramine hydrochloride)
    Prescription only

    Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

    • Available dosage forms:
    • Pill
  • tranylcypromine
    Prescription only

    Parnate (tranylcypromine) is not a first choice medicine to treat depression because of its side effects and interactions with other medicines and foods.

    • Available dosage forms:
    • Pill
  • Trintellix (Vortioxetine) is a new type of serotonin modulating antidepressant that can be tried when the other antidepressants don't work, but some people may find the side effects intolerable and the cost expensive.

    • Available dosage forms:
    • Pill
  • Vivactil
    (protriptyline)
    Prescription only

    Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.

    • Available dosage forms:
    • Pill
  • Wellbutrin
    (bupropion)
    Prescription only

    Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

    • Available dosage forms:
    • Pill
    • Extended release
  • Zoloft
    (sertraline)
    Prescription only

    Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

    • Available dosage forms:
    • Pill
    • Liquid
  • Zyprexa
    (olanzapine)
    Prescription only

    Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
    • Injection
  • Anafranil
    (clomipramine)
    Prescription only

    Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

    • Available dosage forms:
    • Pill
  • Buspar
    (buspirone)
    Prescription only

    Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.

    • Available dosage forms:
    • Pill
  • Dexedrine
    (dextroamphetamine)
    Prescription only

    Dexedrine (dextroamphetamine) is an effective medicine for treatment of ADHD, but often abused for recreational purposes.

    • Available dosage forms:
    • Pill
    • Extended release
    • Liquid
  • fluvoxamine
    Prescription only

    Luvox CR (fluvoxamine) is a first choice treatment for obsessive-compulsive disorder, but it can lower your sex drive.

    • Available dosage forms:
    • Pill
    • Extended release
  • Mirapex
    (pramipexole)
    Prescription only

    Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

    • Available dosage forms:
    • Pill
    • Extended release
  • Risperdal
    (risperidone)
    Prescription only

    Risperdal (risperidone) is an effective medication in treating schizophrenia, mania, and irritability associated with autism; however, amongst other newer medications in its class, it's more likely to cause side effects, such weight gain and hormone problems.

    • Available dosage forms:
    • Pill
    • Dissolving tablet
    • Liquid
    • Injection
  • Tegretol
    (carbamazepine)
    Prescription only

    Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.

    • Available dosage forms:
    • Pill
    • Extended release
    • Chewable tablet
    • Oral suspension
  • Viibryd
    (vilazodone)
    Prescription only

    Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

    • Available dosage forms:
    • Pill
  • Provigil
    (modafinil)
    Prescription only

    Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

    • Available dosage forms:
    • Pill
  • Lamictal
    (lamotrigine)
    Prescription only

    Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

    • Available dosage forms:
    • Pill
    • Extended release
    • Chewable tablet
    • Dissolving tablet

Medication side effects for Depression

These are some of the most common side effects from clinical trials for Abnormal dreams.

  • Seroquel: 2%
0 of 100

At this end, no one is expected to have Abnormal dreams

100 of 100

At this end, almost everyone is expected to have Abnormal dreams

Tips, success stories, and coping strategies for Depression

What tip would you give someone like me who was just diagnosed?
  • don't try to live in the past, it'll kill you
  • Be patient, it may take some time to get relief
  • Keep your mind focused on the how to get better for the future
What’s your best coping strategy?
  • Take it slow
  • Know you will have good and bad days it's ok
  • Meditation helps me calm the mind and think with ration
Besides medications, what else has worked for you?
  • Sleeping and exercising!
  • Intellectual stimulation (e.g. reading)
  • Caffeine