(Upset stomach)

About Indigestion

Nearly everyone has had indigestion at one time. It's a feeling of discomfort or a burning feeling in your upper abdomen. You may have heartburn or belch and feel bloated. You may also feel nauseated, or even throw up.

You might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. Smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. Sometimes the cause is a problem with the digestive tract, like an ulcer or GERD.

Avoiding foods and situations that seem to cause it may help. Because indigestion can be a sign of a more serious problem, see your health care provider if it lasts for more than two weeks or if you have severe pain or other symptoms. Your health care provider may use x-rays, lab tests, and an upper endoscopy to diagnose the cause. You may need medicines to treat the symptoms.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • Also known as
  • Upset stomach
  • Dyspepsia

Top Medications for Indigestion according to our users

Button Group. All currently active

All Medications for Indigestion


  • Acid reducer > Histamine blocker

  • Acid reducer > Proton pump inhibitor

    • Aciphex
      Prescription only

      Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

      Was it worth it?
      • Available dosage forms:
      • Extended release
    • Omeprazole
      Prescription or OTC

      Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

      • Available dosage forms:
      • Extended release
  • Anti-nausea > Dopamine receptor antagonist

    • Reglan
      Prescription only

      Reglan (Metoclopramide) helps get your digestive system moving and lowers nausea and vomiting. Using it a long time can come with serious, potentially permanent side effects.

      Was it worth it?
      • Available dosage forms:
      • Pill
      • Dissolving tablet
      • Liquid

Medication side effects for Indigestion

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Tips, success stories, and coping strategies for Indigestion

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