Prescription onlyLower-cost generic availableClass: Dermatologic

Accutane Alternatives

(isotretinoin)

Prescription onlyLower-cost generic availableClass: Dermatologic
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Compare Accutane (isotretinoin) to alternatives

These medications are comparable to Accutane (isotretinoin) or used for similar purposes.

Accutane
(isotretinoin)

Epiduo
(adapalene / benzoyl peroxide)

Duac
(clindamycin / benzoyl peroxide)

Vibramycin
(doxycycline)

Accutane
(isotretinoin)

Benzamycin
(benzoyl peroxide / erythromycin)

Duac
(clindamycin / benzoyl peroxide)

Solodyn
(minocycline)

Differen
(adapalene)

Renova
(tretinoin)

Treats severe acne and facial redness. Accutane (Isotretinoin) may be the last hope if you have severe, resistant, nodular acne. Talk to your doctor about the risk of birth defects, serious side effects, access restrictions and required patient contract to make sure it's right for you.Coming soon.Coming soon.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Treats severe acne and facial redness. Accutane (Isotretinoin) may be the last hope if you have severe, resistant, nodular acne. Talk to your doctor about the risk of birth defects, serious side effects, access restrictions and required patient contract to make sure it's right for you.Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..Coming soon.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.Coming soon.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.85Accutane
Reviews for Accutane (isotretinoin)
53%
of people (All ages) say Accutane (isotretinoin) is worth it
43%
say it works well
36%
say it's a big hassle
101 reviews
Have you used Accutane (isotretinoin)?
Worth itNot sureNot worth it
Reviews for Epiduo (adapalene / benzoyl peroxide)
Not enough review data. Review it!
+27% better vs. Accutane (isotretinoin)
Not enough review data. Review it!
+37% better vs. Accutane (isotretinoin)
Not enough review data. Review it!
+36% better vs. Accutane (isotretinoin)
Have you used Epiduo (adapalene / benzoyl peroxide)?
Worth itNot sureNot worth it
Reviews for Duac (clindamycin / benzoyl peroxide)
Not enough review data. Review it!
-53% worse vs. Accutane (isotretinoin)
Not enough review data. Review it!
-43% worse vs. Accutane (isotretinoin)
Not enough review data. Review it!
+36% better vs. Accutane (isotretinoin)
Have you used Duac (clindamycin / benzoyl peroxide)?
Worth itNot sureNot worth it
Reviews for Vibramycin (doxycycline)
49%
-4% worse vs. Accutane (isotretinoin)
36%
-7% worse vs. Accutane (isotretinoin)
24%
+12% better vs. Accutane (isotretinoin)
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Benzamycin (benzoyl peroxide / erythromycin)
54%
+1% better vs. Accutane (isotretinoin)
26%
-17% worse vs. Accutane (isotretinoin)
12%
+24% better vs. Accutane (isotretinoin)
146 reviews
Have you used Benzamycin (benzoyl peroxide / erythromycin)?
Worth itNot sureNot worth it
Reviews for Solodyn (minocycline)
53%
Same vs. Accutane (isotretinoin)
59%
+16% better vs. Accutane (isotretinoin)
18%
+18% better vs. Accutane (isotretinoin)
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it
Reviews for Differen (adapalene)
Not enough review data. Review it!
-20% worse vs. Accutane (isotretinoin)
Not enough review data. Review it!
-10% worse vs. Accutane (isotretinoin)
Not enough review data. Review it!
+3% better vs. Accutane (isotretinoin)
Have you used Differen (adapalene)?
Worth itNot sureNot worth it
Reviews for Renova (tretinoin)
41%
-12% worse vs. Accutane (isotretinoin)
28%
-15% worse vs. Accutane (isotretinoin)
28%
+8% better vs. Accutane (isotretinoin)
Have you used Renova (tretinoin)?
Worth itNot sureNot worth it
Side effects
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova

The Accutane FDA package insert doesn’t have numbers about how common side effects are.

More about Accutane side effects »

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »

We haven’t found good data for Duac side effects.

FDA side effect reports for Duac »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »

The Accutane FDA package insert doesn’t have numbers about how common side effects are.

More about Accutane side effects »
  • Dyness 3%
  • Urticarial reaction 3%
More Benzamycin side effects »

We haven’t found good data for Duac side effects.

FDA side effect reports for Duac »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »
  • Mild skin reactions 100%
  • Severe local irritation 6%
  • Any side effect 4%
  • Skin hypo- or hyperpigmentation 2%
More Renova side effects »
How it works
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
Accutane (Isotretinoin) is a medicine for severe acne. Researchers don't know exactly how it works, but it seems to make oil glands smaller and produce less oil. It also keeps cells under the skin's surface from becoming tough.Coming soon.Coming soon.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Accutane (Isotretinoin) is a medicine for severe acne. Researchers don't know exactly how it works, but it seems to make oil glands smaller and produce less oil. It also keeps cells under the skin's surface from becoming tough.Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.Coming soon.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Coming soon.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
  • Pill
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Pill
  • Extended release
  • Extended release capsule
  • Cream, gel, or ointment
  • Cream, gel, or ointment
Used for
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
  • Acne Vulgaris
  • Acne Vulgaris
  • Acne Vulgaris
  • Acne Vulgaris
Risk factors for serious side effects
AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
  • History of depression or other psychiatric condition
  • Taking with Accutane (Isotretinoin) with tetracycline
  • Diabetes
  • Alcohol intake
  • Family history of lipid conditions
Detailed Accutane (isotretinoin) risks & warnings »
    Coming soon.
      Coming soon.
      • Age 8 years or younger
      • Using oral birth control pills
      • Long antibiotic treatment period
      • Women of childbearing age
      Detailed Vibramycin (doxycycline) risks & warnings »
      • History of depression or other psychiatric condition
      • Taking with Accutane (Isotretinoin) with tetracycline
      • Diabetes
      • Alcohol intake
      • Family history of lipid conditions
      Detailed Accutane (isotretinoin) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
      • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
      Detailed Benzamycin (benzoyl peroxide / erythromycin) risks & warnings »
        Coming soon.
        • Age 8 years or younger
        • Using oral birth control pills
        • Long antibiotic treatment period
        • Women of childbearing age
        Detailed Solodyn (minocycline) risks & warnings »
          Coming soon.
          • Using other medicines or products that irritate the skin
          • Eczema
          • Extreme temperatures (hot or cold)
          • Allergy to fish or fish products
          Detailed Renova (tretinoin) risks & warnings »
          Pregnancy

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Price
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          No price related info.No price related info.No price related info.No price related info.No price related info.No price related info.No price related info.
          • Available as a generic, so it should be reasonably priced.
          No price related info.No price related info.
          Interactions
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Avoid some prescription and OTC drugs that interact including: vitamin A, tetracycline, progestin-only birth-control, Dilantin (phenytoin), corticosteroids, and St. John's Wort.
          No interactions related info.No interactions related info.No interactions related info.
          • Avoid some prescription and OTC drugs that interact including: vitamin A, tetracycline, progestin-only birth-control, Dilantin (phenytoin), corticosteroids, and St. John's Wort.
          No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
          Food
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Absorption differs greatly depending on whether it's taken with food and what type food (high fat food or meals increase its absorption into the body).
          No food related info.No food related info.No food related info.
          • Absorption differs greatly depending on whether it's taken with food and what type food (high fat food or meals increase its absorption into the body).
          No food related info.No food related info.No food related info.No food related info.No food related info.
          Pain
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Accutane (Isotretinoin) can cause muscle weakness, joint and bone pain, back pain, and sudden onset of osteoporosis or bone fractures. This is especially the case in teenagers who play sports with repeat injury. There are also cases of early growth plate closure and loss of bone density that did not return to normal (pre-Accutane (Isotretinoin)) in teenagers.
          No pain related info.No pain related info.No pain related info.
          • Accutane (Isotretinoin) can cause muscle weakness, joint and bone pain, back pain, and sudden onset of osteoporosis or bone fractures. This is especially the case in teenagers who play sports with repeat injury. There are also cases of early growth plate closure and loss of bone density that did not return to normal (pre-Accutane (Isotretinoin)) in teenagers.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          No pain related info.No pain related info.No pain related info.No pain related info.
          Weight
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Has a lot of very serious side effects, so think about weighing risks and benefits, and talk to your doctor.
          No weight related info.No weight related info.No weight related info.
          • Has a lot of very serious side effects, so think about weighing risks and benefits, and talk to your doctor.
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          No weight related info.No weight related info.No weight related info.No weight related info.
          Upsides and benefits
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Works for people with severe (nodular) acne that hasn't responded to anything else including oral antibiotics.
          Coming soonComing soon
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Works for people with severe (nodular) acne that hasn't responded to anything else including oral antibiotics.
          • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
          • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
          • Although Benzamycin can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          Coming soon
          • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
          • Available as a generic, so it should be reasonably priced.
          • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
          • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
          Coming soon
          • You only need to apply it once a day, usually in the evening.
          • Most people who reported having skin irritation said that it was mild.
          • Part of a complete program to help you take better care of your skin.
          Downsides and risks
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Has a lot of very serious side effects, so think about weighing risks and benefits, and talk to your doctor.
          • Accutane is restricted to specific doctors and pharmacies through the iPledge program.
          • Make sure you're not pregnant before starting Accutane. It can cause serious birth defects.
          • Can raise the risk of suicidal thoughts or behavior that can continue after you stop it.
          Coming soonComing soon
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          • Has a lot of very serious side effects, so think about weighing risks and benefits, and talk to your doctor.
          • Accutane is restricted to specific doctors and pharmacies through the iPledge program.
          • Make sure you're not pregnant before starting Accutane. It can cause serious birth defects.
          • Can raise the risk of suicidal thoughts or behavior that can continue after you stop it.
          • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          • Can cause bleaching of hair and clothing.
          • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
          Coming soon
          • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
          • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
          Coming soon
          • It may take up to 6 months to see the full benefit for facial wrinkles.
          • Not a good choice for women who want to become or are pregnant
          • Can change the color and texture of your skin if used long-term.
          • You need to be careful about avoiding any sunlight or artificial tanning while using it.
          • It doesn't work for deep wrinkles.
          Tips from our pharmacists for people taking the medication
          AccutaneEpiduoDuacDoxycyclineAccutaneBenzamycinDuacMinocyclineDifferenRenova
          • Take by mouth twice a day.
          • Don't suck on or chew the capsule because it can hurt your throat.
          • Absorption differs greatly depending on whether it's taken with food and what type food (high fat food or meals increase its absorption into the body).
          • Women need to be on two separate types of birth control and start one month before taking Accutane.
          • Not a good choice if you have family history of depression, liver disease, diabetes, heart disease, eating disorder, bone loss, asthma or food/drug allergies.
          • Your doctor will prescribe a dose custom-made for you based on your body weight so don't change your dose on your own.
          • Avoid some prescription and OTC drugs that interact including: vitamin A, tetracycline, progestin-only birth-control, Dilantin (phenytoin), corticosteroids, and St. John's Wort.
          • Some formulations contain soybean oil so be careful if you have any food allergies.
          • Don't worry if you miss a dose, just wait and take your next dose. Don't double your dose.
          • You'll need to have a pregnancy test and other blood testing once a month to check cholesterol and liver enzymes.
          Coming soonComing soon
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          • Take by mouth twice a day.
          • Don't suck on or chew the capsule because it can hurt your throat.
          • Absorption differs greatly depending on whether it's taken with food and what type food (high fat food or meals increase its absorption into the body).
          • Women need to be on two separate types of birth control and start one month before taking Accutane.
          • Not a good choice if you have family history of depression, liver disease, diabetes, heart disease, eating disorder, bone loss, asthma or food/drug allergies.
          • Your doctor will prescribe a dose custom-made for you based on your body weight so don't change your dose on your own.
          • Avoid some prescription and OTC drugs that interact including: vitamin A, tetracycline, progestin-only birth-control, Dilantin (phenytoin), corticosteroids, and St. John's Wort.
          • Some formulations contain soybean oil so be careful if you have any food allergies.
          • Don't worry if you miss a dose, just wait and take your next dose. Don't double your dose.
          • You'll need to have a pregnancy test and other blood testing once a month to check cholesterol and liver enzymes.
          • Combination medicine you apply to your skin to treat acne.
          • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
          • Store in the refrigerator, but don't freeze.
          • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          Coming soon
          • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
          • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
          • Can stain your teeth, tongue and gums, but this is temporary.
          • Take this exactly how your doctor or pharmacist tells you until it's all gone.
          • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
          Coming soon
          • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
          • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
          • Apply a very small amount (pea-size) on entire face once a day at bedtime.
          • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
          • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
          • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
          • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
          Learn more
          More about AccutaneSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Accutane (isotretinoin)?
          Worth itNot sureNot worth it
          More about EpiduoSide effectsReviews & ratingsFDA package insert
          Have you used Epiduo (adapalene / benzoyl peroxide)?
          Worth itNot sureNot worth it
          More about DuacSide effectsFDA package insert
          Have you used Duac (clindamycin / benzoyl peroxide)?
          Worth itNot sureNot worth it
          More about DoxycyclineSide effectsReviews & ratingsFDA package insert
          Have you used Vibramycin (doxycycline)?
          Worth itNot sureNot worth it
          More about AccutaneSide effectsReviews & ratingsFDA package insert
          Have you used Accutane (isotretinoin)?
          Worth itNot sureNot worth it
          More about BenzamycinSide effectsReviews & ratingsFDA package insert
          Have you used Benzamycin (benzoyl peroxide / erythromycin)?
          Worth itNot sureNot worth it
          More about DuacSide effectsFDA package insert
          Have you used Duac (clindamycin / benzoyl peroxide)?
          Worth itNot sureNot worth it
          More about MinocyclineSide effectsReviews & ratingsFDA package insert
          Have you used Solodyn (minocycline)?
          Worth itNot sureNot worth it
          More about DifferenSide effectsReviews & ratingsFDA package insert
          Have you used Differen (adapalene)?
          Worth itNot sureNot worth it
          More about RenovaSide effectsReviews & ratingsFDA package insert
          Have you used Renova (tretinoin)?
          Worth itNot sureNot worth it