Prescription onlyLower-cost generic availableClass: Pain

Tylenol #3

(acetaminophen / codeine)

Prescription onlyLower-cost generic availableClass: Pain
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Treats mild to moderate pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Price and discounts
Prices and coupon for 20 (300mg/30mg) tablets of acetaminophen / codeine

Upsides

  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
People say this drug is:
581 reviews

Downsides

  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
How it works

Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.

What to expect when you take Tylenol #3 (acetaminophen / codeine) for Pain

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Side effect rates for Tylenol #3 (acetaminophen / codeine)

Common concerns from people taking Tylenol #3 (acetaminophen / codeine)

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Pregnancy
Alcohol
  • Avoid alcohol.
Food
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • Don't take more than instructed to prevent liver damage.
Pain
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Good for as-needed pain and control.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • It only works great for mild-moderate pain relief. Needed something stronger the 1st mo of my injury.
  • I find it doesnt really get rid of the pain, the pain still hovers there in the background like a friend waving though the window. The codeine just makes you not notice it as much, still worth taking if you live with pain every day.
Sleep
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.