Prescription onlyLower-cost generic available

Tylenol #3

(Acetaminophen / Codeine)

  • Pill
  • Liquid
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Treats mild to moderate pain.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addition. Learn more about these drugs and be sure to discuss the risks with your doctor.
Worth it?Is it worth it?
Effectiveness?Is it effective?
Hassle?Is it a hassle?
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Tylenol #3 (Acetaminophen / Codeine)

Manufacturers don’t say how common these side effects are

  • Abdominal pain
  • Abnormally slow breathing
  • Agranulocytosis
  • Allergic reactions
  • Constipation
  • Dizziness
  • Drowsiness
  • Euphoria
  • Intense emotional discomfort
  • Itching
  • Lightheadedness
  • Nausea
  • Rash
  • Relaxation or sleepiness
  • Shortness of breath
  • Thrombocytopenia
  • Vomiting

What to expect when you start Tylenol #3 (Acetaminophen / Codeine)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.

Tips from pharmacists and people taking Tylenol #3 (Acetaminophen / Codeine)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • Avoid alcohol.
  • Upsides and downsides from our pharmacists
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Tips from our pharmacists
  • Take it with food to lower the chance of an upset stomach.
  • To take with a bit of food.
    Age: 36
    Gender: man
    Taken for: Pain (mild to moderately-severe)
    Duration taken: less than a week