Prescription onlyLower-cost generic availableClass: Pain

Tylenol #3 

(acetaminophen / codeine)

Prescription onlyLower-cost generic availableClass: Pain
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Treats mild to moderate pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

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Upsides

  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
People say this drug is:
581 reviews

Downsides

  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
How it works

Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.

What to expect when you take Tylenol #3 (acetaminophen / codeine) for Pain

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Side effect rates for Tylenol #3 (acetaminophen / codeine)

Common concerns from people taking Tylenol #3 (acetaminophen / codeine)

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Pregnancy
Alcohol
  • Avoid alcohol.
Food
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • Don't take more than instructed to prevent liver damage.
Pain
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Good for as-needed pain and control.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • It only works great for mild-moderate pain relief. Needed something stronger the 1st mo of my injury.
  • I find it doesnt really get rid of the pain, the pain still hovers there in the background like a friend waving though the window. The codeine just makes you not notice it as much, still worth taking if you live with pain every day.
Sleep
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.