Prescription onlyLower-cost generic available

Aciphex

(Rabeprazole)

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Treats heartburn and ulcers.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
  • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
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Side effects for Aciphex (Rabeprazole)

From clinical trials of Aciphex / Gastroesophageal Reflux Disease (GERD) ( 200)

  • HeadacheHeadache10% for Rabeprazole vs.0% for placebo
  • DiarrheaDiarrhea5% for Rabeprazole vs.0% for placebo
  • DiarrheaDiarrhea5% for Rabeprazole vs.0% for placebo
  • HeadacheHeadache5% for Rabeprazole vs.0% for placebo
  • NauseaNausea5% for Rabeprazole vs.0% for placebo
  • Abdominal painAbdominal pain5% for Rabeprazole vs.0% for placebo
  • VomitingVomiting4% for Rabeprazole vs.0% for placebo
  • Abdominal painAbdominal pain4% for Rabeprazole vs.0% for placebo
  • Sore throatSore throat3% for Rabeprazole vs.2% for placebo
  • Passing gasPassing gas3% for Rabeprazole vs.1% for placebo

What to expect when you take Aciphex (Rabeprazole)

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Tips from our pharmacists
  • Can take a few days to start working.
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).

Risks and Warnings for Aciphex (Rabeprazole)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Aciphex (Rabeprazole) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Aciphex (Rabeprazole)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
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  • Tips from our pharmacists
  • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.