Prescription onlyLower-cost generic available

Aciphex Alternatives

(Rabeprazole)

Back to: Full Site Navigation

Compare Aciphex (Rabeprazole) to alternatives

These medications are comparable to Aciphex (Rabeprazole) or used for similar purposes.

Aciphex
(Rabeprazole)

Dexilant
(Dexlansoprazole)

Nexium
(Esomeprazole)

Prilosec
(Omeprazole)

Protonix
(Pantoprazole)

Pepcid
(Famotidine)

Prevacid
(Lansoprazole)

Tagamet
(Cimetidine)

Zantac 75
(Ranitidine)

Treats heartburn and ulcers. Aciphex (Rabeprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn and stomach ulcers. Nexium (Esomeprazole) gives you long-lasting heartburn relief. But this purple pill ain't cheap! The generic forms of alternative drugs work just as well, and are usually less expensive.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Dexilant (Dexlansoprazole)
93%
7% vs. Aciphex (Rabeprazole)
93%
7% vs. Aciphex (Rabeprazole)
9%
9% vs. Aciphex (Rabeprazole)
Reviews for Nexium (Esomeprazole)
75%
25% vs. Aciphex (Rabeprazole)
59%
41% vs. Aciphex (Rabeprazole)
11%
11% vs. Aciphex (Rabeprazole)
Reviews for Prilosec (Omeprazole)
80%
20% vs. Aciphex (Rabeprazole)
59%
41% vs. Aciphex (Rabeprazole)
7%
7% vs. Aciphex (Rabeprazole)
Reviews for Protonix (Pantoprazole)
69%
31% vs. Aciphex (Rabeprazole)
51%
49% vs. Aciphex (Rabeprazole)
13%
13% vs. Aciphex (Rabeprazole)
Reviews for Pepcid (Famotidine)
75%
25% vs. Aciphex (Rabeprazole)
41%
59% vs. Aciphex (Rabeprazole)
8%
8% vs. Aciphex (Rabeprazole)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Tagamet (Cimetidine)
63%
37% vs. Aciphex (Rabeprazole)
36%
64% vs. Aciphex (Rabeprazole)
12%
12% vs. Aciphex (Rabeprazole)
Reviews for Zantac 75 (Ranitidine)
72%
28% vs. Aciphex (Rabeprazole)
43%
57% vs. Aciphex (Rabeprazole)
7%
7% vs. Aciphex (Rabeprazole)
Side effects
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
  • Passing gas 2%
  • Pain 2%
  • Constipaton 1%
  • Infection 1%
  • Sore throat 1%
More Aciphex side effects »
  • Diarrhea 2%
  • Ear, nose, or throat infection 2%
  • Passing gas 2%
  • Vomiting 1%
More Dexilant side effects »

The Nexium FDA package insert doesn’t have numbers about how common side effects are.

More about Nexium side effects »

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
  • Headache 2%
More Tagamet side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
Aciphex (Rabeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Nexium (Esomeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
  • Extended release
  • Extended release
  • Extended release
  • Extended release
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Dissolving tablet extended release
  • Pill
  • Liquid
  • Pill
  • Oral solution
  • Injection
Used for (click to learn more)
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
Risk factors for serious side effects
AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Aciphex (Rabeprazole) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
      • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
      • Take 1 hour before a meal.
      • Take 1 hour before a meal.
      • Take with or without food.
      • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
      No specific food-related info.
      • Take Prevacid (Lansoprazole) about 1 hour before a meal.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
      No specific kidneys and liver-related info.
      • People with kidney disease may need to take a lower dose.
      • People with kidney disease may need to take a lower dose.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
      • Your body won't develop a tolerance to Aciphex (Rabeprazole), so it'll work the same way as long as you need to keep taking it.
      • Once heartburn symptoms are treated, a low dose of Aciphex (Rabeprazole) can be taken daily.
      • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
      • Lasts longer than other similar stomach medicines. Most people take it once a day.
      • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
      • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
      • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
      • Lasts longer than other similar stomach medicines. Most people take it once a day.
      • Most people can take Nexium without any noticeable day-to-day side effects.
      • Nexium lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
      • Most people can take Omeprazole without any noticeable day-to-day side effects.
      • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
      • Most people can take Pantoprazole without any noticeable day-to-day side effects.
      • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
      • Most people can take Famotidine without any noticeable day-to-day side effects.
      • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
      • Few drug interactions.
      • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
      • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
      • Most people can take Cimetidine without any noticeable day-to-day side effects.
      • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
      • Most people can take Ranitidine without any noticeable day-to-day side effects.
      • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
      • Few drug interactions.
      Downsides and risks
      AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
      • Taking Aciphex (Rabeprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
      • Many drugs can interact with Aciphex (Rabeprazole), so talk to your doctor or pharmacist before starting any new medicines.
      • There's no generic version available, so it can be expensive.
      • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
      • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
      • There's no generic version available, so it can be expensive.
      • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Nexium long-term.
      • Can be expensive—especially the purple brand-name pill. Other alternatives are usually cheaper than Nexium and work just as well.
      • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
      • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
      • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
      • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
      • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
      • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
      • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
      • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
      • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
      • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
      • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
      • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
      • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
      • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
      • Has more drug interactions than zantac and pepcid.
      • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
      • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
      • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
      Tips from our pharmacists for people taking the medication
      AciphexDexilantNexiumOmeprazolePantoprazolePepcidPrevacidTagametZantac
      • Take Aciphex (Rabeprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
      • Aciphex (Rabeprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Aciphex (Rabeprazole).
      • Can take a few days to start working.
      • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
      • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
      • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
      • Can take a few days to start working.
      • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
      • When using Nexium long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
      • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Nexium.
      • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
      • Take 1 hour before a meal.
      • Don't chew or crush capsules; swallow them whole.
      • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
      • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
      • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
      • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
      • Take 1 hour before a meal.
      • Don't chew or crush capsules; swallow them whole.
      • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
      • Take with or without food.
      • Swallow tablets whole; don't split, crush, or chew.
      • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
      • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
      • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
      • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
      • Short-term treatment of ulcers and acid reflux.
      • Take Prevacid (Lansoprazole) about 1 hour before a meal.
      • Don't chew or crush capsules, but swallow them whole.
      • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
      • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
      • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
      • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
      • Works best if you take it with a full glass of water.
      • Starts working in one hour.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • People with kidney disease may need to take a lower dose.
      • Works best if you take it with a full glass of water.
      • Starts working in one hour.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • People with kidney disease may need to take a lower dose.
      Learn more
      More about AciphexSide effectsReviews & ratingsAlternativesFDA package insert
      More about DexilantSide effectsReviews & ratingsFDA package insert
      More about NexiumSide effectsReviews & ratingsFDA package insert
      More about OmeprazoleSide effectsReviews & ratingsFDA package insert
      More about PantoprazoleSide effectsReviews & ratingsFDA package insert
      More about PepcidSide effectsReviews & ratingsFDA package insert
      More about PrevacidSide effectsReviews & ratingsFDA package insert
      More about TagametSide effectsReviews & ratingsFDA package insert
      More about ZantacSide effectsReviews & ratingsFDA package insert