Prescription onlyLower-cost generic availableClass: Endocrine

Actoplus Met

(pioglitazone / metformin)

Prescription onlyLower-cost generic availableClass: Endocrine
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Lowers blood sugar.

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Our bottom line

Actoplus Met (pioglitazone / metformin) is a single-pill combination of two first-choice anti-diabetic medicines, but may cause some undesireable side effects.

Upsides

  • Lowers A1c (average blood sugar) levels by 1%.
  • Easily taken by mouth as a pill.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
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Downsides

  • Can take several weeks to see full effect on your blood sugars.
  • Can cause stomach upset or weight gain.
  • Can cause fluid build up in the ankles or lungs.
  • Not a good choice if you have history of heart failure or bladder cancer.
  • Increases the risk of of bone fractures or poor kidney function.
How it works

Actoplus Met (pioglitazone / metformin) is a combination anti-diabetic medicine, which enhances your body's sensitivy to insulin and lowers production of sugar.

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Dosage forms
  • Pill
  • Extended release

What to expect when you take Actoplus Met (pioglitazone / metformin) for Type 2 diabetes

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Side effect rates for Actoplus Met (pioglitazone / metformin)

Risks and Warnings for Actoplus Met (pioglitazone / metformin)

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    • Higher risk if:
    • Heart failure

    Pioglitazone, one of the medicines in Actoplus Met (pioglitazone / metformin), can cause fluid buildup that can lead to or worsen heart failure. If you have advanced heart failure, talk to your doctor since you shouldn't use Actoplus Met (pioglitazone / metformin). Your doctor will check your heart regularly while you're taking Actoplus Met (pioglitazone / metformin).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Actoplus Met (pioglitazone / metformin)

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Food
  • Take with food to reduce stomach upset.
Kidneys and liver
  • If you've had liver problems or damage in the past, talk to your doctor before starting Actoplus Met (pioglitazone / metformin), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
  • Increases the risk of of bone fractures or poor kidney function.
Weight
  • Can cause diarrhea, weight gain and cold-like symptoms.
  • Can cause stomach upset or weight gain.