Prescription onlyClass: Endocrine



Prescription onlyClass: Endocrine
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Lowers blood sugar.

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Our bottom line

Adlyxin (lixisenatide) can lower blood sugar in addition to metformin, but it must be injected and usually causes upset stomach.


  • Lowers A1c (average blood sugar over time) up to 1%.
  • Not as likely to cause very low blood sugar as glyburide or insulin.
  • Adlyxin (lixisenatide) is injected once daily.
  • Adlyxin (lixisenatide) comes as a pre-filled injectable pen that does not require you to measure the dose, so you may find this more convenient than other types of injections.


  • Not good enough by itself if you have really high blood sugars. It needs to be combined with other oral anti-diabetic medicines or insulin.
  • Commonly causes upset stomach.
  • Can affect how well your birth control pills work. Take 1 hour before or 11 hours after injecting Adlyxin (lixisenatide).
  • Oral diabetes medicines work just as well and are cheaper.
How it works

Adlyxin (lixisenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.

What to expect when you take Adlyxin (lixisenatide) for Type 2 diabetes

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Side effect rates for Adlyxin (lixisenatide)

4508 From clinical trials of Adlyxin / Type 2 diabetes
  • Stomach discomfort
  • Nausea
  • Vomiting
  • Headache
  • Diarrhea
  • Dizziness
  • Injection site reaction
  • Upset stomach
  • Constipation
  • Signs of low blood sugar

Risks and Warnings for Adlyxin (lixisenatide)

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  • Some people may find that Adlyxin (lixisenatide) doesn't work as well over time. They may also notice redness and itchiness where they inject it. Talk to your doctor if this happens to you, since you might have to switch to a different medicine to get better control of your blood sugar.

Common concerns from people taking Adlyxin (lixisenatide)

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Kidneys and liver
  • Adlyxin (lixisenatide) can cause or worsen kidney damage. Let your doctor know if you are unable to urinate or not urinating normally. If you've had kidney problems, talk to your doctor before using Adlyxin (lixisenatide) since your doctor might check your kidneys or give you another medicine.
  • Drink plenty of water to stay hydrated and to prevent kidney damage.