Prescription onlyClass: Endocrine

Adlyxin Alternatives

(lixisenatide)

Prescription onlyClass: Endocrine
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Compare Adlyxin (lixisenatide) to alternatives

These medications are comparable to Adlyxin (lixisenatide) or used for similar purposes.

Adlyxin
(lixisenatide)

Byetta
(exenatide)

Byetta
(exenatide)

Victoza
(liraglutide)

Trulicity
(dulaglutide)

Lowers blood sugar. Adlyxin (lixisenatide) can lower blood sugar in addition to metformin, but it must be injected and usually causes upset stomach.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers your blood sugar. Victoza (liraglutide) is a medicine you inject once a day to control diabetes, but it can be expensive.Lowers your blood sugar. Trulicity (dulaglutide) is a once-weekly injectable medicine that's used to control diabetes, but it can be expensive.
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Reviews & ratings
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Have you used Adlyxin (lixisenatide)?
Worth itNot sureNot worth it

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Have you used Byetta (exenatide)?
Worth itNot sureNot worth it

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Have you used Byetta (exenatide)?
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Reviews for Victoza
73%
-73% worse vs. Adlyxin
91%
-91% worse vs. Adlyxin
27%
+27% better vs. Adlyxin
Have you used Victoza (liraglutide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trulicity (dulaglutide)?
Worth itNot sureNot worth it
Side effects
AdlyxinByettaByettaVictozaTrulicity
  • Stomach discomfort 22%
  • Nausea 19%
  • Vomiting 8%
  • Headache 3%
  • Diarrhea 2%
  • Dizziness 3%
  • Injection site reaction 2%
  • Upset stomach 3%
  • Constipation 1%
More Adlyxin side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Nausea 13%
  • Headache 4%
  • Diarrhea 6%
  • Low appetite 9%
  • Runny nose and congestion 1%
  • Head cold 1%
  • Vomiting 4%
  • Constipation 4%
  • Indigestion 3%
  • Back pain 1%
More Victoza side effects »
  • Nausea 7%
  • Diarrhea 2%
  • Stomach pain 2%
  • Vomiting 4%
  • Low appetite 3%
  • Low blood sugar 4%
  • Tiredness 1%
  • Constipation 3%
  • Indigestion 2%
More Trulicity side effects »
How it works
AdlyxinByettaByettaVictozaTrulicity
Adlyxin (lixisenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Victoza (liraglutide) is a medication for diabetes. It stimulates your body to make and release more insulin, stops the body from releasing more sugar, and slows down digestion.Trulicity (dulaglutide) is a medication for diabetes. It stimulates your body to make and release more insulin, stops the body from releasing more sugar, and slows down digestion.
Type of medication
AdlyxinByettaByettaVictozaTrulicity
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
AdlyxinByettaByettaVictozaTrulicity
  • Injection
  • Injection
  • Injection
  • Injection
  • Injection
Used for
AdlyxinByettaByettaVictozaTrulicity
Risk factors for serious side effects
AdlyxinByettaByettaVictozaTrulicity
  • History of pancreatitis
  • History of gallstones
  • alcoholism
  • Elevated triglycerides
  • Several renal impairment
Detailed Adlyxin (lixisenatide) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
  • History of MTC
  • History of MEN 2
  • History of pancreatitis
  • History of gallstones
  • alcoholism
Detailed Victoza (liraglutide) risks & warnings »
  • History of MTC
  • History of MEN 2
  • History of pancreatitis
  • History of gallstones
  • alcoholism
Detailed Trulicity (dulaglutide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
AdlyxinByettaByettaVictozaTrulicity
  • Adlyxin (lixisenatide) can cause or worsen kidney damage. Let your doctor know if you are unable to urinate or not urinating normally. If you've had kidney problems, talk to your doctor before using Adlyxin (lixisenatide) since your doctor might check your kidneys or give you another medicine.
  • Drink plenty of water to stay hydrated and to prevent kidney damage.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
  • Victoza (liraglutide) can cause or worsen kidney damage. This is more likely to happen if you've had nausea or vomiting, diarrhea or dehydration. Make sure to drink plenty of fluids and stay hydrated when you're sick. If you have kidney damage already, your doctor might do regular lab tests while you're taking Victoza (liraglutide) to make sure your kidneys stay healthy.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Trulicity (dulaglutide) can cause or worsen kidney damage. This is more likely to happen if you've had nausea or vomiting, diarrhea or dehydration. Make sure to drink plenty of fluids and stay hydrated when you're sick. If you have kidney damage already, your doctor might do regular lab tests while you're taking Trulicity (dulaglutide) to make sure your kidneys stay healthy.
  • No limitation for people with kidney problems, but close monitoring is recommended.
Pain
AdlyxinByettaByettaVictozaTrulicity
No pain related info.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
No pain related info.No pain related info.
Weight
AdlyxinByettaByettaVictozaTrulicity
No weight related info.No weight related info.No weight related info.
  • Helps with weight loss and controls appetite.
  • May help with weight loss and controling appetite.
Upsides and benefits
AdlyxinByettaByettaVictozaTrulicity
  • Lowers A1c (average blood sugar over time) up to 1%.
  • Not as likely to cause very low blood sugar as glyburide or insulin.
  • Adlyxin (lixisenatide) is injected once daily.
  • Adlyxin (lixisenatide) comes as a pre-filled injectable pen that does not require you to measure the dose, so you may find this more convenient than other types of injections.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Lowers A1c (average blood sugar over time) up to 1.5%.
  • Helps with weight loss and controls appetite.
  • Only medicine in this class with proven heart health benefits.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Medicine is ready to use, without need to mix.
  • Lowers A1c (average blood sugar over time) up to 1.5%.
  • May help with weight loss and controling appetite.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Dosed once a week compared to other injectables that have to be done daily.
  • Medicine is ready to use, without need to mix.
Downsides and risks
AdlyxinByettaByettaVictozaTrulicity
  • Not good enough by itself if you have really high blood sugars. It needs to be combined with other oral anti-diabetic medicines or insulin.
  • Commonly causes upset stomach.
  • Can affect how well your birth control pills work. Take 1 hour before or 11 hours after injecting Adlyxin (lixisenatide).
  • Oral diabetes medicines work just as well and are cheaper.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Only available as an injection.
  • Brand name medicine and can be expensive.
  • Compared to other similar medicines, you have to inject this every day.
  • Only available as an injection.
  • Brand name medicine and can be expensive.
  • Many people taking Trulicity (dulaglutide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
Tips from our pharmacists for people taking the medication
AdlyxinByettaByettaVictozaTrulicity
  • Inject into your belly, thighs, or upper arm within 1 hour of your first meal of the day.
  • If you miss a dose, wait until the next meal to inject your dose.
  • Store unused pens in the refrigerator until you're ready to use them. Keep used pen at room temperature and away from light.
  • Discard the pen 14 days after the first use, even if there's medicine still inside.
  • Drink plenty of water to stay hydrated and to prevent kidney damage.
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
  • Inject the dose given by your doctor daily at the same time on your belly, thighs, or the back of your upper arm. To be used with or without food.
  • You may have low appetite, nausea, vomiting, diarrhea, or stomach pain, which may get better with time.
  • Let your doctor know if you have severe and/or persistent stomach pain or nausea with or without vomiting.
  • Unused pens should be stored in the refrigerator, but the pen in use can be kept at room temperature for up to 30 days.
  • Each pen has only 1 dose and it's ready for use.
  • Inject once a week in your belly, thighs, or the back of your upper arm with or without food.
  • If you miss a dose, take the medicine as soon as you remember, unless the next dose is within the next 72 hours, then skip the missed dose.
  • You may have low appetite, nausea, vomiting, diarrhea, or stomach pain, which may get better with time.
  • Let your doctor know if you have severe and/or persistent stomach pain or nausea with or without vomiting.
  • Unopened pens should be kept in the refrigerator, or at room temperature for up to 14 days, but never in the freezer.
Learn more
More about AdlyxinSide effectsAlternativesFDA package insert
Have you used Adlyxin (lixisenatide)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsFDA package insert
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsFDA package insert
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
More about VictozaSide effectsReviews & ratingsFDA package insert
Have you used Victoza (liraglutide)?
Worth itNot sureNot worth it
More about TrulicitySide effectsFDA package insert
Have you used Trulicity (dulaglutide)?
Worth itNot sureNot worth it