Prescription onlyLower-cost generic availableClass: Cardiovascular


(spironolactone / hydrochlorothiazide)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Lowers blood pressure. Removes extra water from your body.

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Our bottom line

Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.

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  • Lowers the risk of heart attack and stroke.
  • Has a low risk of causing muscle problems due to low potassium levels in your blood.
  • Gets rid of extra fluids in your body.
  • Helpful for people who tend to have low potassium levels.


  • Many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • Needs blood tests to monitor electrolytes and kidney function.
  • Can make you urinate more often.
  • Can make you sensitive to sunlight.
  • Shouldn't take it if you have a sulfa allergy.
How it works

Aldactazide (Spironolactone / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with two diuretics (water pills), hydrochlorothiazide and spironolactone. They act on different parts of your kidney to get rid of extra fluids.

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Side effect rates for Aldactazide (spironolactone / hydrochlorothiazide)

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These are side effects of Aldactazide (spironolactone / hydrochlorothiazide) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Aldactazide (spironolactone / hydrochlorothiazide)

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  • Use of Aldactazide (Spironolactone / Hydrochlorothiazide) in rats showed higher risk of tumor growth, and should only be used for FDA approved indications.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Aldactazide (spironolactone / hydrochlorothiazide)

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Kidneys and liver
  • Needs blood tests to monitor electrolytes and kidney function.
  • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
  • Aldactazide (Spironolactone / Hydrochlorothiazide) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.