Prescription onlyLower-cost generic availableClass: Cardiovascular

Aldactone Alternatives

(spironolactone)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Compare Aldactone (spironolactone) to alternatives

These medications are comparable to Aldactone (spironolactone) or used for similar purposes.

Aldactone
(spironolactone)

Midamor
(amiloride)

Dyrenium
(triamterene)

Inspra
(eplerenone)

Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.Coming soon.Coming soon.Helps lower blood pressure and protect the heart in people with heart failure. Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.
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Best available price for 30 (25mg) tablets of spironolactone
Reviews & ratings
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Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it

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Have you used Midamor (amiloride)?
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Have you used Dyrenium (triamterene)?
Worth itNot sureNot worth it

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Have you used Inspra (eplerenone)?
Worth itNot sureNot worth it
Side effects
spironolactoneAmilorideTriamtereneInspra

The spironolactone FDA package insert doesn’t have numbers about how common side effects are.

More about spironolactone side effects »

We haven’t found good data for Amiloride side effects.

FDA side effect reports for Amiloride »

We haven’t found good data for Triamterene side effects.

FDA side effect reports for Triamterene »
  • High potassium 1%
  • Abnormal renal function 1%
  • Dizziness 1%
  • Diarrhea 1%
  • Coughing 1%
  • Fatigue 1%
  • Flu-like symptoms 1%
More Inspra side effects »
How it works
spironolactoneAmilorideTriamtereneInspra
Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.Coming soon.Coming soon.Inspra (eplerenone) is an aldosterone antagonist. It blocks aldosterone (a hormone) and helps your kidneys get rid of excess fluid in your body, which helps lower blood pressure.
Type of medication
spironolactoneAmilorideTriamtereneInspra
Prescription onlyPrescription only
Available as
spironolactoneAmilorideTriamtereneInspra
  • Pill
  • Pill
  • Pill
  • Pill
Used for
spironolactoneAmilorideTriamtereneInspra
  • Congestive Heart Failure Hypertension
  • Edema
Risk factors for serious side effects
spironolactoneAmilorideTriamtereneInspra
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
  • Current kidney problems
  • Taking other medicines that increase potassium
  • Use of salt substitutes
Detailed Aldactone (spironolactone) risks & warnings »
    Coming soon.
      Coming soon.
      • Taking with alcohol
      • Taking other medicines that lower your blood pressure
      • Current kidney problems
      • Medicines that increase potassium
      • Use of salt substitutes
      Detailed Inspra (eplerenone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Kidneys and liver
      spironolactoneAmilorideTriamtereneInspra
      • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
      No kidneys and liver related info.No kidneys and liver related info.
      • Inspra (eplerenone) shouldn't be used by people with bad kidneys since it can hurt your kidneys or cause worse side effects, such as high potassium levels. Your doctor will do frequent blood tests to monitor your kidney function and electrolytes while you're on this drug.
      • Shouldn't be used by people with kidney or liver damage.
      • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
      Pain
      spironolactoneAmilorideTriamtereneInspra
      • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
      No pain related info.No pain related info.No pain related info.
      Upsides and benefits
      spironolactoneAmilorideTriamtereneInspra
      • Has a low risk of causing muscle problems from low potassium levels in your blood.
      • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
      • Can lower blood pressure.
      • Reduces the risk of death in people with heart failure.
      Coming soonComing soon
      • Lowers your blood pressure.
      • It can help remove fluid from your body when it's used with other drugs.
      • Reduces the risk of death in people with heart failure.
      • It can have fewer side effects than spironolactone.
      Downsides and risks
      spironolactoneAmilorideTriamtereneInspra
      • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
      • Has many possible side effects, especially when higher doses are used.
      • Can increase the risk of tumor growth.
      • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
      Coming soonComing soon
      • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
      • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
      • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
      • It can be very expensive compared to spironolactone.
      Tips from our pharmacists for people taking the medication
      spironolactoneAmilorideTriamtereneInspra
      • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
      • Don't use supplements or salt substitutes that are high in potassium.
      • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
      • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
      • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
      Coming soonComing soon
      • Inspra (eplerenone) can make you feel dizzy the first few days you're taking it.
      • It can increase your potassium to dangerous levels, so don't use salt substitutes or other products that contain potassium.
      • Women may notice breast tenderness or swelling and irregular periods.
      • Shouldn't be used by people with kidney or liver damage.
      • Your doctor will check the amount of potassium in your blood while you're on this drug.
      Learn more
      More about spironolactoneSide effectsAlternativesFDA package insert
      Have you used Aldactone (spironolactone)?
      Worth itNot sureNot worth it
      More about AmilorideSide effectsFDA package insert
      Have you used Midamor (amiloride)?
      Worth itNot sureNot worth it
      More about TriamtereneSide effectsFDA package insert
      Have you used Dyrenium (triamterene)?
      Worth itNot sureNot worth it
      More about InspraSide effectsReviews & ratingsFDA package insert
      Have you used Inspra (eplerenone)?
      Worth itNot sureNot worth it