Over-the-counterNo lower cost generic available

Alka-Seltzer Plus Cold

(Aspirin / Chlorpheniramine / Phenylephrine)

  • Effervescent tablet
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Relieves cold symptoms.

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Over-the-counterNo lower cost generic available

Our pharmacists’ bottom line

Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

  • Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • It's available in a variety of flavors.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) interacts with many other drugs and health conditions.
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Side effects for Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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These are side effects of Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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Tips from our pharmacists
  • Chlorpheniramine (the antihistamine ingredient in Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Don't take Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) if you're pregnant.

Risks and Warnings for Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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    • Higher risk if:
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day

    Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) contains aspirin, which can cause serious problems including inflammation, bleeding, and ulcers in the stomach or intestines. The longer you take Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine), the higher the risk is. If you notice blood or a dark/black color in your stool, tell your doctor right away.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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The FDA category for this medication is N. It is advised that you: Unknown
Pregnancy