Over-the-counterNo lower cost generic available

Alka-Seltzer Plus Cold And Cough Alternatives

(Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)

  • Pill
  • Effervescent tablet
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Compare Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) to alternatives

These medications are comparable to Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) or used for similar purposes.

Alka-Seltzer Plus Cold And Cough
(Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)

Alka-Seltzer Plus Day Cold And Flu
(Acetaminophen / Dextromethorphan / Phenylephrine)

Brotapp
(Pseudoephedrine / Brompheniramine)

Tylenol Cold And Flu Severe
(Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin)

Tylenol Cold Multi-Symptom Daytime
(Acetaminophen / Dextromethorphan / Phenylephrine)

Relieves coughing and cold symptoms. Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves congestion and allergy symptoms. Brotapp (Pseudoephedrine / Brompheniramine) is okay for treating congestion, but it could make you really tired or keep you wide awake.Relieves cold and flu symptoms. Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is an okay combination medicine that relieves cold and flu symptoms, so make sure you really need all of its ingredients.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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Side effects
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Alka-Seltzer Plus Cold and Cough side effects.

FDA side effect reports for Alka-Seltzer Plus Cold and Cough »

We haven’t found good data for Alka-Seltzer Plus Day Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold and Flu »

We haven’t found good data for Brotapp side effects.

FDA side effect reports for Brotapp »

We haven’t found good data for Tylenol Cold and Flu Severe side effects.

FDA side effect reports for Tylenol Cold and Flu Severe »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Brotapp (Pseudoephedrine / Brompheniramine) is a combination medicine that relieves allergy and cold symptoms. Brompheniramine (an antihistamine) treats runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin is an expectorant that breaks up and thins out mucus.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
Pain reliever
Salicylate
Antihistamine
1st generation
Cough suppressantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
DecongestantAntihistamine
1st generation
Over-the-counter
Pain reliever
APAP
DecongestantCough suppressantExpectorantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Available as
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
  • Pill
  • Effervescent tablet
  • Pill
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Powder
Used for (click to learn more)
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Women of childbearing age
  • Age 18 years or younger
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
  • Brompheniramine (the antihistamine) can make you dizzy and drowsy. It could increase the risk of falls for elderly people.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Brotapp (Pseudoephedrine / Brompheniramine) is a combination medicine that relieves cold and allergy symptoms. It's good to use if you have congestion, watery eyes, and sneezing.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
  • Brompheniramine (an antihistamine) helps relieve itchy eyes, runny nose, and sneezing.
  • Tylenol Cold And Flu Severe (Acetaminophen / Phenylephrine / Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • Pseudoephedrine (the decongestant) can make your heart race or make you feel anxious and restless.
  • Brompheniramine (the antihistamine) can make you dizzy and drowsy. It could increase the risk of falls for elderly people.
  • The two ingredients in this medication can make you either really tired or keep you wide awake. See how it affects you before doing anything important.
  • Two of the medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan stops you from coughing.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Cold and CoughAlka-Seltzer Plus Day Cold and FluBrotappTylenol Cold and Flu SevereTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Chlorpheniramine (the antihistamine in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Don't take Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) if you're pregnant.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Brompheniramine (the antihistamine ingredient in Brotapp (Pseudoephedrine / Brompheniramine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Pseudoephedrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • You need to show an ID to buy Brotapp (Pseudoephedrine / Brompheniramine) in the drugstore because it contains pseudoephedrine.
  • Don't crush, chew, or dissolve the caplets.
  • Follow age-specific dosing instructions on how much to take.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert
More about Alka-Seltzer Plus Day Cold and FluSide effectsReviews & ratingsFDA package insert
More about BrotappSide effectsReviews & ratingsFDA package insert
More about Tylenol Cold and Flu SevereSide effectsReviews & ratingsFDA package insert
More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsFDA package insert