Over-the-counterNo lower cost generic available

Alka-Seltzer Plus Cold Alternatives

(Aspirin / Chlorpheniramine / Phenylephrine)

  • Effervescent tablet
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Compare Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) to alternatives

These medications are comparable to Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) or used for similar purposes.

Alka-Seltzer Plus Cold
(Aspirin / Chlorpheniramine / Phenylephrine)

Brotapp
(Pseudoephedrine / Brompheniramine)

Advil Congestion Relief
(Ibuprofen / Phenylephrine)

Tylenol Sinus
(Acetaminophen / Phenylephrine)

Dimetapp Cold And Allergy
(Phenylephrine / Brompheniramine)

Advil Cold And Sinus
(Ibuprofen / Pseudoephedrine)

Allegra D
(Pseudoephedrine / Fexofenadine)

Relieves cold symptoms. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves congestion and allergy symptoms. Brotapp (Pseudoephedrine / Brompheniramine) is okay for treating congestion, but it could make you really tired or keep you wide awake.Relieves pain and congestion. Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.Relieves congestion and allergy symptoms for kids. Dimetapp Cold And Allergy (Phenylephrine / Brompheniramine) is good for multiple nasal symptoms, but it can make you really drowsy.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.
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Reviews & ratings
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Reviews for Advil Congestion Relief (Ibuprofen / Phenylephrine)
73%
+6% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
32%
35% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
7%
7% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
Reviews for Tylenol Sinus (Acetaminophen / Phenylephrine)
74%
+7% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
31%
36% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
5%
5% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)
75%
+8% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
34%
33% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)
6%
6% vs. Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D

We haven’t found good data for Alka-Seltzer Plus Cold side effects.

FDA side effect reports for Alka-Seltzer Plus Cold »

We haven’t found good data for Brotapp side effects.

FDA side effect reports for Brotapp »

We haven’t found good data for Advil Congestion Relief side effects.

FDA side effect reports for Advil Congestion Relief »

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »

We haven’t found good data for Dimetapp Cold and Allergy side effects.

FDA side effect reports for Dimetapp Cold and Allergy »

We haven’t found good data for Advil Cold and Sinus side effects.

FDA side effect reports for Advil Cold and Sinus »
  • Back pain 2%
More Allegra D side effects »
How it works
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.Brotapp (Pseudoephedrine / Brompheniramine) is a combination medicine that relieves allergy and cold symptoms. Brompheniramine (an antihistamine) treats runny nose, sneezing, and itchy eyes or skin. Pseudoephedrine (a decongestant) clears your sinuses.Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Phenylephrine is a decongestant that clears your sinuses.Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.Dimetapp Cold And Allergy (Phenylephrine / Brompheniramine) is a combination medicine that relieves allergy and cold symptoms. Brompheniramine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itchy eyes or skin. Phenylephrine (a decongestant) clears your sinuses.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
Pain reliever
Salicylate
Antihistamine
1st generation
DecongestantOver-the-counter
DecongestantAntihistamine
1st generation
Over-the-counter
Pain reliever
NSAID
DecongestantOver-the-counter
Pain reliever
APAP
DecongestantOver-the-counter
DecongestantAntihistamine
1st generation
Over-the-counter
Pain reliever
NSAID
DecongestantOver-the-counter
DecongestantAntihistamine
2nd generation
Prescription or OTC
Available as
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
  • Effervescent tablet
  • Pill
  • Liquid
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
Risk factors for serious side effects
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Women of childbearing age
  • Age 18 years or younger
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Brompheniramine (the antihistamine) can make you dizzy and drowsy. It could increase the risk of falls for elderly people.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
No specific sleep-related info.No specific sleep-related info.
  • Brompheniramine (the antihistamine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
No specific sleep-related info.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
  • Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, fever, and pain.
  • It's available in a variety of flavors.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Brotapp (Pseudoephedrine / Brompheniramine) is a combination medicine that relieves cold and allergy symptoms. It's good to use if you have congestion, watery eyes, and sneezing.
  • Brompheniramine (an antihistamine) helps relieve itchy eyes, runny nose, and sneezing.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dimetapp Cold And Allergy (Phenylephrine / Brompheniramine) is a combination medicine with a decongestant and an antihistamine that's helpful in treating nasal symptoms related to cold and allergy.
  • Brompheniramine (the antihistamine) is useful for itchy eyes, runny nose, or constant sneezing.
  • Phenylephrine (the decongestant) is good for relieving congestion.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
Downsides and risks
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • The aspirin in Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) interacts with many other drugs and health conditions.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • Pseudoephedrine (the decongestant) can make your heart race or make you feel anxious and restless.
  • Brompheniramine (the antihistamine) can make you dizzy and drowsy. It could increase the risk of falls for elderly people.
  • The two ingredients in this medication can make you either really tired or keep you wide awake. See how it affects you before doing anything important.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • If you don't really need both of the medications in this combination, you'd be taking extra medicine and might have extra side effects for no reason.
  • Brompheniramine (the antihistamine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • Phenylephrine (the decongestant) doesn't last as long as other oral decongestants like pseudoephedrine, but can cause jitteriness.
  • The two medications in this medicine can somewhat work against each other, with one making you sleepy and the other making you jittery.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus ColdBrotappAdvil Congestion ReliefTylenol SinusDimetapp Cold and AllergyAdvil Cold and SinusAllegra D
  • Chlorpheniramine (the antihistamine ingredient in Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Don't take Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) if you're pregnant.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Brompheniramine (the antihistamine ingredient in Brotapp (Pseudoephedrine / Brompheniramine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Pseudoephedrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • You need to show an ID to buy Brotapp (Pseudoephedrine / Brompheniramine) in the drugstore because it contains pseudoephedrine.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Follow age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Starts working in 30 minutes.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Only use the provided dosage cup to measure the medicine. Don't use a spoon.
  • Follow the age-specific dosing instructions on how much to take. Don't take more than what's recommended on the package.
  • Talk to a doctor if the symptoms don't get better in 1 week.
  • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Take it after eating to avoid getting an upset stomach.
  • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
  • Talk to your doctor if symptoms don't get better in 1 week.
  • Starts working in 30 minutes.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
Learn more
More about Alka-Seltzer Plus ColdSide effectsReviews & ratingsAlternativesFDA package insert
More about BrotappSide effectsReviews & ratingsFDA package insert
More about Advil Congestion ReliefSide effectsReviews & ratingsFDA package insert
More about Tylenol SinusSide effectsReviews & ratingsFDA package insert
More about Dimetapp Cold and AllergySide effectsReviews & ratingsFDA package insert
More about Advil Cold and SinusSide effectsReviews & ratingsFDA package insert
More about Allegra DSide effectsReviews & ratingsFDA package insert