Over-the-counterLower-cost generic availableClass: Respiratory

Alka-Seltzer Plus Day Severe Cold And Flu Alternatives

(acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Over-the-counterLower-cost generic availableClass: Respiratory
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Compare Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) to alternatives

These medications are comparable to Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) or used for similar purposes.

Alka-Seltzer Plus Day Severe Cold And Flu
(acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Alka-Seltzer Plus Day Severe Cold And Flu
(acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Alka-Seltzer Plus Day Severe Cold And Flu
(acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Dayquil Cold And Flu
(acetaminophen / phenylephrine / dextromethorphan)

Mucinex Dm
(dextromethorphan / guaifenesin)

Robitussin Dm
(guaifenesin / dextromethorphan)

Mucinex D
(guaifenesin / pseudoephedrine)

Tylenol Cold Multi-Symptom Daytime
(acetaminophen / dextromethorphan / phenylephrine)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is okay for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is okay for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is okay for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Breaks up mucus and relieves cough. Robitussin Dm (Guaifenesin / Dextromethorphan) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. You have to take it more often than other guaifenesin products.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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Reviews for Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Not enough review data. Review it!
of people (All ages) say Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)
81%
+81% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
38%
+38% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
5%
-5% worse vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
1034 reviews
Have you used Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan)?
Worth itNot sureNot worth it
Reviews for Mucinex Dm (dextromethorphan / guaifenesin)
73%
+73% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
73%
+73% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
13%
-13% worse vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Have you used Mucinex Dm (dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it
Reviews for Robitussin Dm (guaifenesin / dextromethorphan)
75%
+75% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
37%
+37% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
7%
-7% worse vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
724 reviews
Have you used Robitussin Dm (guaifenesin / dextromethorphan)?
Worth itNot sureNot worth it
Reviews for Mucinex D (guaifenesin / pseudoephedrine)
76%
+76% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
41%
+41% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
7%
-7% worse vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
1249 reviews
Have you used Mucinex D (guaifenesin / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)
Not enough review data. Review it!
+100% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Not enough review data. Review it!
+100% better vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Not enough review data. Review it!
Same vs. Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Side effects
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Alka-Seltzer Plus Day Severe Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Severe Cold And Flu »

We haven’t found good data for Alka-Seltzer Plus Day Severe Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Severe Cold And Flu »

We haven’t found good data for Alka-Seltzer Plus Day Severe Cold And Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Severe Cold And Flu »

We haven’t found good data for Dayquil Cold And Flu side effects.

FDA side effect reports for Dayquil Cold And Flu »

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Robitussin DM side effects.

FDA side effect reports for Robitussin DM »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin breaks up mucus and phlegm.Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin breaks up mucus and phlegm.Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin breaks up mucus and phlegm.Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Over-the-counter
Available as
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Powder
  • Liquid
  • Pill
  • Powder
  • Liquid
  • Pill
  • Powder
  • Liquid
  • Pill
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Liquid
  • Liquid
  • Extended release
  • Pill
  • Liquid
  • Powder
Used for
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Alka-Seltzer Plus Day Severe Cold And Flu (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Dayquil Cold And Flu (acetaminophen / phenylephrine / dextromethorphan) risks & warnings »
  • Using other medications that affect serotonin
Detailed Mucinex Dm (dextromethorphan / guaifenesin) risks & warnings »
  • Using other medications that affect serotonin
Detailed Robitussin Dm (guaifenesin / dextromethorphan) risks & warnings »
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
Detailed Mucinex D (guaifenesin / pseudoephedrine) risks & warnings »
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Kidneys and liver
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
No pain related info.No pain related info.No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Upsides and benefits
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The extended release version of Mucinex DM lasts up to 12 hours.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up and causes productive, wet coughs.
  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Guaifenesin isn’t useful if you have a dry cough without chest congestion.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Guaifenesin isn’t useful if you have a dry cough without chest congestion.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Guaifenesin isn’t useful if you have a dry cough without chest congestion.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Robitussin Dm (Guaifenesin / Dextromethorphan)) stops you from coughing.
  • Needs to be taken more often during the day than other products with guaifenesin, like Mucinex.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluAlka-Seltzer Plus Day Severe Cold And FluDayquil Cold And FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Follow age-specific dosing instructions on how much to take.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
  • If your cough lasts more than 7 days, call your doctor.
  • Drink plenty of fluids while taking Robitussin Dm (Guaifenesin / Dextromethorphan) because liquid helps break down mucus.
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • If your cough lasts more than 7 days, call your doctor.
  • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Severe Cold And FluSide effectsAlternativesFDA package insert
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