Over-the-counterLower-cost generic available

Alka-Seltzer Plus Day Severe Cold And Flu Alternatives

(Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)

  • Powder
  • Liquid
  • Pill
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Compare Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) to alternatives

These medications are comparable to Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) or used for similar purposes.

Alka-Seltzer Plus Day Severe Cold And Flu
(Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)

Dayquil Cold And Flu
(Acetaminophen / Phenylephrine / Dextromethorphan)

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Robitussin Dm
(Guaifenesin / Dextromethorphan)

Mucinex D
(Guaifenesin / Pseudoephedrine)

Tylenol Cold Multi-Symptom Daytime
(Acetaminophen / Dextromethorphan / Phenylephrine)

Relieves cold and flu symptoms. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is okay for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a useful combination medicine that relieves cold and flu symptoms, but make sure you really need all of its ingredients.Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Breaks up mucus and relieves cough. Robitussin Dm (Guaifenesin / Dextromethorphan) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. You have to take it more often than other guaifenesin products.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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Reviews for Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan)
81%
+81% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
37%
+37% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
5%
5% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)

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Reviews for Robitussin Dm (Guaifenesin / Dextromethorphan)
75%
+75% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
37%
+37% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
7%
7% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
+76% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
41%
+41% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)
7%
7% vs. Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Alka-Seltzer Plus Day Severe Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Severe Cold and Flu »

We haven’t found good data for DayQuil Cold and Flu side effects.

FDA side effect reports for DayQuil Cold and Flu »

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Robitussin DM side effects.

FDA side effect reports for Robitussin DM »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin breaks up mucus and phlegm.Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Pain reliever
Acetaminophen (APAP)
Cough suppressantExpectorantDecongestantOver-the-counter
Pain reliever
APAP
DecongestantCough suppressantOver-the-counter
Cough suppressantExpectorantOver-the-counter
ExpectorantCough suppressantOver-the-counter
ExpectorantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Available as
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Powder
  • Liquid
  • Pill
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Liquid
  • Liquid
  • Extended release
  • Pill
  • Liquid
  • Powder
Used for (click to learn more)
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Dayquil Cold And Flu (Acetaminophen / Phenylephrine / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The extended release version of Mucinex DM lasts up to 12 hours.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up and causes productive, wet coughs.
  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Guaifenesin isn’t useful if you have a dry cough without chest congestion.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • Robitussin Dm (Guaifenesin / Dextromethorphan) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Robitussin Dm (Guaifenesin / Dextromethorphan)) stops you from coughing.
  • Needs to be taken more often during the day than other products with guaifenesin, like Mucinex.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Alka-Seltzer Plus Day Severe Cold and FluDayQuil Cold and FluMucinex DMRobitussin DMMucinex DTylenol Cold Multi-Symptom Daytime
  • Alka-Seltzer Plus Day Severe Cold And Flu (Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine) comes as a powder packet you can dissolve in hot water and drink.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Follow age-specific dosing instructions on how much to take.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • If your cough lasts more than 7 days, call your doctor.
  • Drink plenty of fluids while taking Robitussin Dm (Guaifenesin / Dextromethorphan) because liquid helps break down mucus.
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • If your cough lasts more than 7 days, call your doctor.
  • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
  • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Alka-Seltzer Plus Day Severe Cold and FluSide effectsAlternativesFDA package insert
More about DayQuil Cold and FluSide effectsReviews & ratingsFDA package insert
More about Mucinex DMSide effectsReviews & ratingsFDA package insert
More about Robitussin DMSide effectsReviews & ratingsFDA package insert
More about Mucinex DSide effectsReviews & ratingsFDA package insert
More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsFDA package insert