Alka-Seltzer Plus Night Cold And Flu
Alternatives

(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Over-the-counter
Relieves cold and flu symptoms, and helps you sleep.

Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.

Relieves coughing and cold symptoms.

Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Upsides
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) can help you sleep.
  • Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Phenylephrine (the decongestant ingredient) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Dextromethorphan (the cough suppressant ingredient) works well and has very few side effects.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) interacts with many other drugs and health conditions.
Used for
Dosage forms
  • Pill
  • Pill
  • Effervescent tablet
No pricing information available
No pricing information available
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Side effects
The Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer Plus Cold And Cough (Aspirin / Chlorpheniramine / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Drinking more than 2 alcoholic beverages a day

    ...and 2 more risk factors

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Chronic cough from an infection

    History of chronic obstructive pulmonary disease (COPD)

    ...and 1 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Antihistamine side effects

    Age 65 years or older

    ...and 2 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings
  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Harm to unborn babies

    Women of childbearing age

  • Reye's syndrome

    Age 18 years or younger

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings