Prescription onlyLower-cost generic availableClass: Musculoskeletal



Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Prevents gout flare-ups.

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Our bottom line

Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.

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  • Works well to lower the amount of uric acid in the body to reduce gout attacks.
  • Available as a generic medication.


  • Can actually increase the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of the medication.
  • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
How it works

Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.

What to expect when you take Zyloprim (Allopurinol) for Gout

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Side effect rates for Zyloprim (Allopurinol)

0From clinical trials of Allopurinol / All
  • Acute attacks of gout
  • Skin rash

Risks and Warnings for Zyloprim (Allopurinol)

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  • People who first start Zyloprim (Allopurinol) can experience increased gout attacks as they take the medication for the first few weeks. This is common. Your doctor can prescribe other medications to prevent these attacks from occurring.

Common concerns from people taking Zyloprim (Allopurinol)

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  • Take with food or milk to prevent an upset stomach.