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Zyloprim Alternatives

(Allopurinol)

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Compare Zyloprim (Allopurinol) to alternatives

These medications are comparable to Zyloprim (Allopurinol) or used for similar purposes.

Zyloprim
(Allopurinol)

Uloric
(Febuxostat)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.0476190476190474Allopurinol
Reviews for Zyloprim (Allopurinol)
71%
of people say Zyloprim (Allopurinol) is worth it
52%
say it works well
5%
say it's a big hassle

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Side effects
AllopurinolUloric

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »
How it works
AllopurinolUloric
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.
Type of medication
AllopurinolUloric
Antigout
Xanthine oxidase inhibitor
Prescription only
Antigout
Xanthine oxidase inhibitor
Prescription only
Available as
AllopurinolUloric
  • Pill
  • Pill
Used for (click to learn more)
AllopurinolUloric
Risk factors for serious side effects
AllopurinolUloric
          Detailed Zyloprim (Allopurinol) risks & warnings »
          Coming soon.
          Pregnancy category
          AllopurinolUloric
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take with food or milk to prevent an upset stomach.
          • Take Uloric (Febuxostat) at the same time everyday, with or without food.
          • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
          Kidneys and liver
          • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
          • People who take Zyloprim (Allopurinol) can be more likely to have kidney stones, especially if you're dehydrated. Drink at least 10 to 12 eight ounce glasses of water every day to help prevent that from happening.
          • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
          • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AllopurinolUloric
          • Works well to lower the amount of uric acid in the body to reduce gout attacks.
          • Available as a generic medication.
          • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
          • You only need to take Uloric (Febuxostat) once a day.
          • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
          Downsides and risks
          AllopurinolUloric
          • Can actually increase the number of gout attacks in the first few weeks.
          • It can take 2 to 6 weeks to feel the full effects of the medication.
          • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
          • Can increase the amount of gout attacks in the first few weeks.
          • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
          • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
          • Doesn't come in a generic version.
          Tips from our pharmacists for people taking the medication
          AllopurinolUloric
          • Drink plenty of water while taking this medication.
          • Take with food or milk to prevent an upset stomach.
          • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
          • Your doctor can run blood tests to make sure the medication is working as it should.
          • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
          • Take Uloric (Febuxostat) at the same time everyday, with or without food.
          • To make sure Uloric (Febuxostat) is working, have your blood checked often.
          • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
          Learn more
          More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
          More about UloricSide effectsReviews & ratingsFDA package insert