5.0/ 7 average rating with 21 reviewsforAllopurinol

Zyloprim
Alternatives

(allopurinol)

Zyloprim (allopurinol)

Prescription only

Uloric (febuxostat)

Prescription only
1 of 1 alternatives
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

Stops gout attacks.

Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.

Upsides
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
  • Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
  • You only need to take Uloric (febuxostat) once a day.
  • People with mild to moderate kidney disease can use Uloric (febuxostat).
Downsides
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
  • You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
  • While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
  • You'll have to get your blood checked often with Uloric (febuxostat) therapy.
  • Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
21 
71%
think this treatment is worth it
52%
think this treatment works well
5%
think this treatment is a hassle

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Side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
The Uloric (febuxostat) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Kidney stones

    History of kidney stones

  • Sleepiness or dizziness

    Taking other medications that also cause sleepiness

    ...and 3 more risk factors

See more detailed risks and warnings
  • Blood clots

    History of stroke or heart attack

  • Allergic reaction

    History of skin reaction to allopurinol

See more detailed risks and warnings