Prescription onlyLower-cost generic available

Zyloprim Alternatives

(Allopurinol)

Prescription onlyLower-cost generic available
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Compare Zyloprim (Allopurinol) to alternatives

These medications are comparable to Zyloprim (Allopurinol) or used for similar purposes.

Zyloprim
(Allopurinol)

Uloric
(Febuxostat)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.
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Reviews & ratings
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Have you used Zyloprim (Allopurinol)?
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Have you used Uloric (Febuxostat)?
Worth itNot sureNot worth it
Side effects
AllopurinolUloric

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »
How it works
AllopurinolUloric
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.
Type of medication
AllopurinolUloric
Antigout
Xanthine oxidase inhibitor
Prescription only
Antigout
Xanthine oxidase inhibitor
Prescription only
Available as
AllopurinolUloric
  • Pill
  • Pill
Used for (click to learn more)
AllopurinolUloric
Risk factors for serious side effects
AllopurinolUloric
          Detailed Zyloprim (Allopurinol) risks & warnings »
                Detailed Uloric (Febuxostat) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Alcohol
                AllopurinolUloric
                No alcohol related info.
                • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
                Food
                AllopurinolUloric
                • Take with food or milk to prevent an upset stomach.
                • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
                Kidneys and liver
                AllopurinolUloric
                No kidneys and liver related info.
                • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
                Upsides and benefits
                AllopurinolUloric
                • Works well to lower the amount of uric acid in the body to reduce gout attacks.
                • Available as a generic medication.
                • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
                • You only need to take Uloric (Febuxostat) once a day.
                • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
                Downsides and risks
                AllopurinolUloric
                • Can actually increase the number of gout attacks in the first few weeks.
                • It can take 2 to 6 weeks to feel the full effects of the medication.
                • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
                • Can increase the amount of gout attacks in the first few weeks.
                • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
                • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
                • Doesn't come in a generic version.
                Tips from our pharmacists for people taking the medication
                AllopurinolUloric
                • Drink plenty of water while taking this medication.
                • Take with food or milk to prevent an upset stomach.
                • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
                • Your doctor can run blood tests to make sure the medication is working as it should.
                • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
                • Take Uloric (Febuxostat) at the same time everyday, with or without food.
                • To make sure Uloric (Febuxostat) is working, have your blood checked often.
                • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
                Learn more
                More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Zyloprim (Allopurinol)?
                Worth itNot sureNot worth it
                More about UloricSide effectsReviews & ratingsFDA package insert
                Have you used Uloric (Febuxostat)?
                Worth itNot sureNot worth it