Prescription onlyLower-cost generic available


(Estradiol Patch)

  • Patch
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Prescription onlyLower-cost generic available

Our bottom line

The Alora (Estradiol Patch) needs to be replaced twice a week, and it may have fewer side effects than oral estrogen pills.


  • The Alora (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.


  • You need to replace the Alora (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Alora (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
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What to expect when you take Alora (Estradiol Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of the skin to lower the risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
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Side effects for Alora (Estradiol Patch)

From clinical trials of Alora / Any condition (.1 mg/day)  ( 261)

  • Vaginal bleedingVaginal bleeding33% for Alora patch vs.13% for placebo
  • HeadacheHeadache21% for Alora patch vs.13% for placebo
  • PainPain19% for Alora patch vs.13% for placebo
  • VaginitisVaginitis18% for Alora patch vs.7% for placebo
  • Sinus inflammationSinus inflammation18% for Alora patch vs.18% for placebo
  • Pain breastPain breast17% for Alora patch vs.8% for placebo
  • Application site reactionApplication site reaction16% for Alora patch vs.59% for placebo
  • Pain backPain back16% for Alora patch vs.6% for placebo
  • Infection respiratoryInfection respiratory16% for Alora patch vs.26% for placebo
  • ItchingItching5% for Alora patch vs.5% for placebo

Manufacturers don’t say how common these side effects are

  • "stomach flu"
  • Bone fracture spontaneous
  • Cyst
  • High blood pressure
  • Infection fungal
  • Joint disorder
  • Middle ear inflammation
  • Pink eye
  • Reduced sense of touch
  • Widening of blood vessels

Risks and Warnings for Alora (Estradiol Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Alora (Estradiol Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe