Prescription onlyLower-cost generic available



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Lowers your blood sugar.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.

  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.
  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.

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Side effects for Amaryl (Glimepiride)

From clinical trials of Amaryl / Type 2 diabetes ( 1039)

  • Low blood sugarLow blood sugar20% for Glimepiride vs.3% for placebo
  • HeadacheHeadache8% for Glimepiride vs.8% for placebo
  • Accidental injuryAccidental injury6% for Glimepiride vs.3% for placebo
  • Flu syndromeFlu syndrome5% for Glimepiride vs.5% for placebo
  • NauseaNausea5% for Glimepiride vs.3% for placebo
  • DizzinessDizziness5% for Glimepiride vs.2% for placebo

What to expect when you start Amaryl (Glimepiride)

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Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
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Risks and Warnings for Amaryl (Glimepiride)

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    • Higher risk if:
    • Skipping meals or inconsistent meal times
    • Drinking alcohol
    • Using other diabetes medications and insulin
    • Autonomic neuropathy
    • Gastroparesis

    People taking Amaryl (Glimepiride) in addition to another medication for diabetes may experience low blood sugar. Very low blood sugar is life-threatening. Talk to your doctor about lowering your dose of Amaryl (Glimepiride) if you have signs of low blood sugar, which may include fast heartbeat, sweating, pale skin, feeling shaky, confusion or irritability.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Amaryl (Glimepiride)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Tips from our pharmacists
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause weight gain.