Prescription onlyLower-cost generic availableClass: Endocrine



Prescription onlyLower-cost generic availableClass: Endocrine
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Lowers your blood sugar.

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Our bottom line

Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.


  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.


  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.
How it works

Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.

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Side effect rates for Amaryl (glimepiride)

1039 From clinical trials of Amaryl / Type 2 diabetes
  • Low blood sugar
  • Headache
  • Accidental injury
  • Flu syndrome
  • Nausea
  • Dizziness

Risks and Warnings for Amaryl (glimepiride)

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    • Higher risk if:
    • Skipping meals or inconsistent meal times
    • Drinking alcohol
    • Using other diabetes medications and insulin
    • Autonomic neuropathy
    • Gastroparesis

    People taking Amaryl (Glimepiride) in addition to another medication for diabetes may experience low blood sugar. Very low blood sugar is life-threatening. Talk to your doctor about lowering your dose of Amaryl (Glimepiride) if you have signs of low blood sugar, which may include fast heartbeat, sweating, pale skin, feeling shaky, confusion or irritability.

Common concerns from people taking Amaryl (glimepiride)

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  • Avoid alcohol when taking Amaryl (Glimepiride).
  • Eat regular, balanced meals to avoid low blood sugar.
  • Can cause weight gain.