Prescription onlyLower-cost generic availableClass: Endocrine

Amaryl Alternatives

(glimepiride)

Prescription onlyLower-cost generic availableClass: Endocrine
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Compare Amaryl (glimepiride) to alternatives

These medications are comparable to Amaryl (glimepiride) or used for similar purposes.

Amaryl
(glimepiride)

Diabeta
(glyburide)

Glucotrol
(glipizide)

Byetta
(exenatide)

Glucophage
(metformin)

Precose
(acarbose)

Actos
(pioglitazone)

Januvia
(sitagliptin)

Lowers your blood sugar. Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Coming soon.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
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Reviews & ratings
Filter group. All currently selected
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Reviews for Amaryl (glimepiride)
Not enough review data. Review it!
of people (All ages) say Amaryl (glimepiride) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
Reviews for Diabeta (glyburide)
45%
-5% worse vs. Amaryl (glimepiride)
34%
-66% worse vs. Amaryl (glimepiride)
21%
+29% better vs. Amaryl (glimepiride)
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
Same vs. Amaryl (glimepiride)
32%
-68% worse vs. Amaryl (glimepiride)
19%
+31% better vs. Amaryl (glimepiride)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Byetta (exenatide)
Not enough review data. Review it!
Same vs. Amaryl (glimepiride)
Not enough review data. Review it!
-50% worse vs. Amaryl (glimepiride)
Not enough review data. Review it!
+50% better vs. Amaryl (glimepiride)
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
+15% better vs. Amaryl (glimepiride)
46%
-54% worse vs. Amaryl (glimepiride)
16%
+34% better vs. Amaryl (glimepiride)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Precose (acarbose)
Not enough review data. Review it!
+50% better vs. Amaryl (glimepiride)
Not enough review data. Review it!
Same vs. Amaryl (glimepiride)
Not enough review data. Review it!
+50% better vs. Amaryl (glimepiride)
Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Actos (pioglitazone)
42%
-8% worse vs. Amaryl (glimepiride)
30%
-70% worse vs. Amaryl (glimepiride)
21%
+29% better vs. Amaryl (glimepiride)
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for Januvia (sitagliptin)
44%
-6% worse vs. Amaryl (glimepiride)
34%
-66% worse vs. Amaryl (glimepiride)
17%
+33% better vs. Amaryl (glimepiride)
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
  • Low blood sugar 17%
  • Accidental injury 3%
  • Nausea 2%
  • Dizziness 3%
More Amaryl side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Coming soon.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
  • Pill
  • Pill
  • Pill
  • Extended release
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Pill
  • Pill
Used for
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
  • Skipping meals or inconsistent meal times
  • Drinking alcohol
  • Using other diabetes medications and insulin
  • Autonomic neuropathy
  • Gastroparesis
Detailed Amaryl (glimepiride) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Glucotrol (glipizide) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
    Coming soon.
    • Heart failure diagnosis
    • Current liver problems
    • Female
    Detailed Actos (pioglitazone) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Alcohol
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Avoid alcohol when taking Amaryl (Glimepiride).
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    • Avoid drinking alcohol.
    No alcohol related info.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    • Limit or avoid alcohol when taking this medicine.
    No alcohol related info.No alcohol related info.No alcohol related info.
    Food
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Eat regular, balanced meals to avoid low blood sugar.
    • Eat well-balanced meals to avoid low blood sugar.
    • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
    • Eat regular, balanced meals to avoid low blood sugar.
    No food related info.
    • Always take it with food to lessen stomach upset.
    No food related info.No food related info.
    • Take once a day in the morning with or without food.
    Kidneys and liver
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    No kidneys and liver related info.
    • Not ideal for elderly or those with poor kidney function.
    • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
    • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
    No kidneys and liver related info.No kidneys and liver related info.
    • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
    Pain
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    No pain related info.No pain related info.No pain related info.
    • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
    No pain related info.No pain related info.No pain related info.
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    Weight
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Can cause weight gain.
    • Can cause weight gain (about 2 to 3 pounds).
    • Can cause weight gain, dizziness, or stomach upset.
    • Can cause mild weight gain (2 to 3 pounds).
    • Can cause weight gain, dizziness, or stomach upset.
    No weight related info.
    • Doesn't cause weight gain.
    No weight related info.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    • Can cause weight gain, headache, and fluid retention.
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    Upsides and benefits
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Has a lower chance of causing low blood sugar than glyburide.
    • Can be taken by mouth instead of getting an injection.
    • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs.
    • Also available as a generic medication, so its cheaper than many other diabetes medications.
    • Available as an oral tablet.
    • Lowers your A1c (average blood sugar over time) up to 2%.
    • Available in generic version.
    • Available in single pill combination with other anti-diabetic medicines.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
    • One of the least expensive diabetes medicines.
    • Can lower your A1c (average blood sugar over time) by 1%.
    • Not as likely to cause very low blood sugar as glyburine or insulin.
    • Does not increase your appetite like other anti-diabetic medicines.
    • Pen is dialed to a single dose for easy injections.
    • Improves sugar control and lowers A1c levels as much as 2%.
    • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
    • Doesn't cause weight gain.
    • Rarely causes low blood sugar.
    Coming soon
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Oral blood sugar-lowering medicine.
    • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
    • Uses the hormones naturally produced by your body to affect how sugar is processed.
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    Downsides and risks
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Can cause weight gain.
    • You need to check your blood sugar 2 to 5 times per week.
    • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
    • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
    • Loses effectiveness over time as your body stops making insulin.
    • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
    • You will have to check your blood sugar often when you first start taking it.
    • Can cause weight gain (about 2 to 3 pounds).
    • Not ideal for elderly or those with poor kidney function.
    • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
    • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
    • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
    • Can cause mild weight gain (2 to 3 pounds).
    • Loses effectiveness over time or as your body stops making insulin.
    • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
    • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
    • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
    • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
    • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    Coming soon
    • May take several weeks to lower blood sugar.
    • You have to check your blood sugar regularly with this medicine.
    • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
    • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
    • Slightly raises the risk of bladder cancer.
    • Lowers A1c (average blood sugar over time) by less than 1%.
    • Available as brand version only.
    • Some people might get frequent cold-like symptoms.
    • Rare but serious side effects include pancreatitis and severe joint pain.
    Tips from our pharmacists for people taking the medication
    AmarylglyburideGlucotrolByettametforminPrecoseActosJanuvia
    • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
    • Eat regular, balanced meals to avoid low blood sugar.
    • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
    • Avoid alcohol when taking Amaryl (Glimepiride).
    • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
    • Check your blood sugar regularly.
    • Eat well-balanced meals to avoid low blood sugar.
    • Works best if you take it 30 minutes before first main meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Avoid drinking alcohol.
    • Eat regular, balanced meals to avoid low blood sugar.
    • Check your blood sugar regularly.
    • Inject into your belly, thighs, or upper arms within an hour of your main meals.
    • Store unused pens in the refrigerator.
    • After first use, pens can be kept at room temperature for 30 days.
    • Change the needle and prime the pen every time you inject.
    • If you're also on insulin, don't inject into the same site.
    • Best to check your blood sugar once a day to make sure your medicine is working properly.
    • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
    • Always take it with food to lessen stomach upset.
    • Stay hydrated.
    • Limit or avoid alcohol when taking this medicine.
    • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
    • Check your blood sugar regularly.
    Coming soon
    • Takes several weeks to see full effect on blood sugar control.
    • Can cause weight gain, headache, and fluid retention.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Not recommended for patients with certain heart problems.
    • Check your blood sugar regularly.
    • Take once a day in the morning with or without food.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    • Tell your doctor right away if you are experiencing severe joint pain.
    • Check your blood sugar regularly to check for low blood sugar.
    Learn more
    More about AmarylSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Amaryl (glimepiride)?
    Worth itNot sureNot worth it
    More about glyburideSide effectsReviews & ratingsFDA package insert
    Have you used Diabeta (glyburide)?
    Worth itNot sureNot worth it
    More about GlucotrolSide effectsReviews & ratingsFDA package insert
    Have you used Glucotrol (glipizide)?
    Worth itNot sureNot worth it
    More about ByettaSide effectsReviews & ratingsFDA package insert
    Have you used Byetta (exenatide)?
    Worth itNot sureNot worth it
    More about metforminSide effectsReviews & ratingsFDA package insert
    Have you used Glucophage (metformin)?
    Worth itNot sureNot worth it
    More about PrecoseSide effectsReviews & ratingsFDA package insert
    Have you used Precose (acarbose)?
    Worth itNot sureNot worth it
    More about ActosSide effectsReviews & ratingsFDA package insert
    Have you used Actos (pioglitazone)?
    Worth itNot sureNot worth it
    More about JanuviaSide effectsReviews & ratingsFDA package insert
    Have you used Januvia (sitagliptin)?
    Worth itNot sureNot worth it