Prescription onlyLower-cost generic availableClass: Neuro/psych

Asendin Alternatives

(amoxapine)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Compare Asendin (amoxapine) to alternatives

These medications are comparable to Asendin (amoxapine) or used for similar purposes.

Asendin
(amoxapine)

Elavil
(amitriptyline)

Silenor
(doxepin)

Tofranil
(imipramine hydrochloride)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.
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Reviews & ratings
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Reviews for Asendin (amoxapine)
Not enough review data. Review it!
of people (All ages) say Asendin (amoxapine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
Reviews for Elavil (amitriptyline)
53%
+53% better vs. Asendin (amoxapine)
36%
+36% better vs. Asendin (amoxapine)
25%
+75% better vs. Asendin (amoxapine)
134 reviews
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
Reviews for Silenor (doxepin)
Not enough review data. Review it!
+100% better vs. Asendin (amoxapine)
Not enough review data. Review it!
+50% better vs. Asendin (amoxapine)
Not enough review data. Review it!
+100% better vs. Asendin (amoxapine)
Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Reviews for Tofranil (imipramine hydrochloride)
Not enough review data. Review it!
Same vs. Asendin (amoxapine)
Not enough review data. Review it!
Same vs. Asendin (amoxapine)
Not enough review data. Review it!
+100% better vs. Asendin (amoxapine)
Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Side effects
amoxapineElavilSilenorTofranil
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »

The Tofranil FDA package insert doesn’t have numbers about how common side effects are.

More about Tofranil side effects »
How it works
amoxapineElavilSilenorTofranil
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.
Type of medication
amoxapineElavilSilenorTofranil
Prescription only
Prescription only
Prescription only
Available as
amoxapineElavilSilenorTofranil
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
Used for
amoxapineElavilSilenorTofranil
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
amoxapineElavilSilenorTofranil
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • Age 24 years or younger
  • History of bipolar disorder
  • At risk for bipolar disorder
  • History of cardiovascular disease
  • Age 65 years or older
Detailed Elavil (amitriptyline) risks & warnings »
    Coming soon.
    • Under age 24
    • History of heart disease
    • Overactive thyroid
    • High blood pressure
    • History of seizures
    Detailed Tofranil (imipramine hydrochloride) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Interactions
    amoxapineElavilSilenorTofranil
    No interactions related info.No interactions related info.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    No interactions related info.
    Alcohol
    amoxapineElavilSilenorTofranil
    No alcohol related info.No alcohol related info.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
    Food
    amoxapineElavilSilenorTofranil
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    No food related info.No food related info.No food related info.
    Pain
    amoxapineElavilSilenorTofranil
    No pain related info.
    • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
    No pain related info.No pain related info.
    Sleep
    amoxapineElavilSilenorTofranil
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • Can cause dizziness, drowsiness, constipation, and weight gain.
    No sleep related info.
    • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
    Weight
    amoxapineElavilSilenorTofranil
    No weight related info.
    • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
    • Doxepin can increase your appetite, leading to weight gain.
    • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).
    Upsides and benefits
    amoxapineElavilSilenorTofranil
    • Asendin (amoxapine) can be used to treat more severe forms of depression.
    • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
    • Asendin (amoxapine) is available as generic.
    • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
    • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
    • Six out of every ten people who use an antidepressant for the first time find that it works for them.
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
    • Available in generic.
    • Tofranil (imipramine hydrochloride) is usually taken only once a day.
    • Available in 3 different strengths.
    Downsides and risks
    amoxapineElavilSilenorTofranil
    • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
    • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
    • Not recommended in older people, children under 16, or people who've had a history of seizures.
    • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
    • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
    • People age 65 and older have a higher risk for this medication's side effects.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
    • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
    • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
    Tips from our pharmacists for people taking the medication
    amoxapineElavilSilenorTofranil
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • You might not notice any changes in your mood for at least a few weeks.
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
    • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
    • Take at bedtime to avoid some of its side effects.
    • Can cause dizziness, drowsiness, constipation, and weight gain.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    • You might need to take Tofranil (imipramine hydrochloride) for a few weeks before you notice any changes in your mood.
    • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
    • If you miss your bedtime dose, skip it and take your regular dose the next evening. Don't take extra medicine to make up for the missed dose.
    • You might be more sensitive to the sun while taking Tofranil (imipramine hydrochloride). Make sure to drink plenty of liquids, wear sunscreen, or cover your skin if you'll be out in the sun.
    • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
    • Don't stop taking Tofranil (imipramine hydrochloride) without talking to your doctor first.
    Learn more
    More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Asendin (amoxapine)?
    Worth itNot sureNot worth it
    More about ElavilSide effectsReviews & ratingsFDA package insert
    Have you used Elavil (amitriptyline)?
    Worth itNot sureNot worth it
    More about SilenorSide effectsReviews & ratingsFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it
    More about TofranilSide effectsReviews & ratingsFDA package insert
    Have you used Tofranil (imipramine hydrochloride)?
    Worth itNot sureNot worth it