Prescription onlyClass: autoimmune



Prescription onlyClass: autoimmune
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Improves walking in patients with MS (multiple sclerosis).

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Our bottom line

Ampyra (dalfampridine) is an oral drug for people with difficulty walking due to MS, but may not work for everyone.


  • There is no other prescription medicine that is proven to improve walking in adults with MS.
  • Ampyra (dalfampridine) can be taken with or without food.


  • Works well for others, but not at all for some.
  • Expensive since it is brand only and is the only drug that could improve walking if you have MS.
  • Ampyra (dalfampridine) won't slow down or stop multiple sclerosis.
How it works

Ampyra (dalfampridine) is believed to enhance conduction of your nerve fibers.

What to expect when you take Ampyra (dalfampridine) for Multiple sclerosis

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Side effect rates for Ampyra (dalfampridine)

638 From clinical trials of Ampyra / Multiple sclerosis (10 mg twice daily)
  • Urinary tract infection
  • Sleep difficulty
  • Dizziness
  • Headache
  • Nausea
  • Lack of energy
  • Back pain
  • Balance disorder
  • Multiple sclerosis relapse
  • Tingling or numbness sensation

Risks and Warnings for Ampyra (dalfampridine)

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    • Higher risk if:
    • History of seizures

    Ampyra (dalfampridine) can cause seizures even in people with no history of seizures. Seizures can happen within days to weeks after starting Ampyra (dalfampridine). Those with a history of seizures should not take Ampyra (dalfampridine). Go to the emergency room and talk to your doctor right away if you do have a seizure.

Common concerns from people taking Ampyra (dalfampridine)

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Kidneys and liver
  • Ampyra (dalfampridine) is removed from your body via your kidneys. If your kidneys don't work well, more Ampyra (dalfampridine) can stay in your body and cause seizures or other serious side effects. You might not be able to take Ampyra (dalfampridine). Talk to your doctor if you have questions