Prescription onlyLower-cost generic availableClass: Mental health

Anafranil 

(clomipramine)

Prescription onlyLower-cost generic availableClass: Mental health
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Our bottom line

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

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Best available price for 60 (50mg) capsules of clomipramine
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Upsides

  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.

Downsides

  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
How it works

Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.

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Side effect rates for Anafranil (clomipramine)

3616 From clinical trials of Anafranil / Obsessive-compulsive disorder
  • Dry mouth
  • Tremor
  • Dizziness
  • Drowsiness
  • Headache
  • Constipation
  • Drowsiness
  • Ejaculation failure
  • Dizziness
  • Fatigue

Risks and Warnings for Anafranil (clomipramine)

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    • Higher risk if:
    • Age 24 years or younger

    Anafranil (Clomipramine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Anafranil (Clomipramine) is not approved for use in children younger than age 10 years.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Anafranil (clomipramine)

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Pregnancy
Food
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.