Prescription onlyLower-cost generic available

Anafranil

(Clomipramine)

  • Pill
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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.

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Side effects for Anafranil (Clomipramine)

From clinical trials of Anafranil / Obsessive-compulsive disorder ( 641)

  • Dry mouthDry mouth84% for Clomipramine vs.17% for placebo
  • Dry mouthDry mouth63% for Clomipramine vs.16% for placebo
  • DrowsinessDrowsiness54% for Clomipramine vs.16% for placebo
  • TremorTremor54% for Clomipramine vs.2% for placebo
  • DizzinessDizziness54% for Clomipramine vs.14% for placebo
  • HeadacheHeadache52% for Clomipramine vs.41% for placebo
  • ConstipationConstipation47% for Clomipramine vs.11% for placebo
  • DrowsinessDrowsiness46% for Clomipramine vs.11% for placebo
  • Ejaculation failureEjaculation failure42% for Clomipramine vs.2% for placebo
  • DizzinessDizziness41% for Clomipramine vs.14% for placebo

Manufacturers don’t say how common these side effects are

  • Abnormal dreaming
  • Acne
  • Dry skin
  • Gastrointestinal disorder
  • Increased appetite
  • Mood swings
  • Nosebleed
  • Passing gas
  • Rash
  • Sore throat
  • Thirst
  • Vocal cord inflammation

What to expect when you take Anafranil (Clomipramine)

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Tips from our pharmacists
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.

Risks and Warnings for Anafranil (Clomipramine)

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    • Higher risk if:
    • Age 24 years or younger

    Anafranil (Clomipramine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Anafranil (Clomipramine) is not approved for use in children younger than age 10 years.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Anafranil (Clomipramine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Tips from our pharmacists
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sex
  • Upsides and downsides from our pharmacists
  • Can cause sexual performance problems in men.
Sleep
  • Upsides and downsides from our pharmacists
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can help you sleep.
  • Risks from our pharmacists
  • Stopping Anafranil (Clomipramine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
  • Taken at night to minimize drowsiness
    Taken for: Panic disorder
    Duration taken: Two years or more
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.