Prescription onlyLower-cost generic availableClass: Mental health

Anafranil Alternatives

(clomipramine)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Anafranil (clomipramine) to alternatives

These medications are comparable to Anafranil (clomipramine) or used for similar purposes.

Anafranil
(clomipramine)

Elavil
(amitriptyline)

Tofranil
(imipramine hydrochloride)

Pamelor
(nortriptyline)

Zoloft
(sertraline)

Prozac
(fluoxetine)

Cymbalta
(duloxetine)

Viibryd
(vilazodone)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
Reviews & ratings
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Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it
Reviews for Elavil
53%
+39% better vs. Anafranil
36%
+39% better vs. Anafranil
25%
+17% better vs. Anafranil
134 reviews
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Pamelor
79%
+13% better vs. Anafranil
79%
-4% worse vs. Anafranil
21%
+13% better vs. Anafranil
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Reviews for Zoloft
59%
+33% better vs. Anafranil
41%
+34% better vs. Anafranil
15%
+7% better vs. Anafranil
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Reviews for Prozac
62%
+30% better vs. Anafranil
40%
+35% better vs. Anafranil
16%
+8% better vs. Anafranil
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Cymbalta
58%
+34% better vs. Anafranil
49%
+26% better vs. Anafranil
24%
+16% better vs. Anafranil
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Reviews for Viibryd
67%
+25% better vs. Anafranil
63%
+12% better vs. Anafranil
13%
+5% better vs. Anafranil
Have you used Viibryd (vilazodone)?
Worth itNot sureNot worth it
Side effects
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »

The Tofranil FDA package insert doesn’t have numbers about how common side effects are.

More about Tofranil side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Nausea 14%
  • Diarrhea/loose stools 9%
  • Sleep difficulty 7%
  • Mouth dry 7%
  • Drowsiness 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating increased 5%
  • Constipation 2%
More Zoloft side effects »
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Diarrhea 19%
  • Nausea 18%
  • Dizziness 4%
  • Dry mouth 3%
  • Sleep difficulty 4%
  • Decreased libido 5%
  • Vomiting 4%
  • Lower sex drive 4%
  • Fatigue 1%
  • Abnormal orgasm 4%
More Viibryd side effects »
How it works
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Pill
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Extended release
  • Pill
Used for
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
Risk factors for serious side effects
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
  • Age 24 years or younger
  • History of bipolar disorder
  • At risk for bipolar disorder
  • History of cardiovascular disease
  • Age 65 years or older
Detailed Elavil (amitriptyline) risks & warnings »
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • High blood pressure
  • History of seizures
Detailed Tofranil (imipramine hydrochloride) risks & warnings »
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
Detailed Prozac (fluoxetine) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Cymbalta (duloxetine) risks & warnings »
  • Age 18 years or younger
  • Taking Viibryd (Vilazodone) with MAOIs
  • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
Detailed Viibryd (vilazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No interactions related info.No interactions related info.No interactions related info.No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
No interactions related info.No interactions related info.No interactions related info.
Alcohol
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No alcohol related info.No alcohol related info.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Food
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Take it with food and/or at bedtime to decrease the potential side effects.
No food related info.No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
No food related info.
  • Take in the morning with food to avoid side effects.
  • Take with food to avoid upset stomach.
  • Take Viibryd (Vilazodone) with food at the same time every day.
Kidneys and liver
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
Pain
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No pain related info.
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
No pain related info.No pain related info.No pain related info.No pain related info.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
No pain related info.
Sex
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No sex related info.No sex related info.No sex related info.No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.No sex related info.
Sleep
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
No sleep related info.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
No sleep related info.No sleep related info.No sleep related info.
Weight
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
No weight related info.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).
No weight related info.No weight related info.No weight related info.No weight related info.No weight related info.
Upsides and benefits
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides and risks
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Tips from our pharmacists for people taking the medication
AnafranilElavilTofranilPamelorZoloftProzacCymbaltaViibryd
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take at bedtime to avoid some of its side effects.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • You might need to take Tofranil (imipramine hydrochloride) for a few weeks before you notice any changes in your mood.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
  • If you miss your bedtime dose, skip it and take your regular dose the next evening. Don't take extra medicine to make up for the missed dose.
  • You might be more sensitive to the sun while taking Tofranil (imipramine hydrochloride). Make sure to drink plenty of liquids, wear sunscreen, or cover your skin if you'll be out in the sun.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Tofranil (imipramine hydrochloride) without talking to your doctor first.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take in the morning with food to avoid side effects.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
Learn more
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it
More about ElavilSide effectsReviews & ratingsFDA package insert
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
More about TofranilSide effectsReviews & ratingsFDA package insert
Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
More about PamelorSide effectsReviews & ratingsFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
More about ZoloftSide effectsReviews & ratingsFDA package insert
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
More about ProzacSide effectsReviews & ratingsFDA package insert
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
More about CymbaltaSide effectsReviews & ratingsFDA package insert
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
More about ViibrydSide effectsReviews & ratingsFDA package insert
Have you used Viibryd (vilazodone)?
Worth itNot sureNot worth it