Prescription onlyNo lower cost generic available


(Drospirenone / Estradiol)

Prescription onlyNo lower cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
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Relieves hot flashes and vaginal dryness due to menopause.

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Our bottom line

Angeliq (Drospirenone / Estradiol) effectively relieves menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

Price and discounts
  • (1) 28 tablets of 0.5mg/1mg package
  • Cost for (1) 28 tablets of 0.5mg/1mg package of Angeliq (Drospirenone / Estradiol) at pharmacies


  • Angeliq (Drospirenone / Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).


  • More potential side effects since it exposes your whole body to two hormones, estrogen and drospirenone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Has a slightly higher risk of blood clots compared to other estrogen-progestin combination pills because of the type of progestin it contains (drospirenone).
  • Must be used carefully with any other medicine that can increase your potassium level.
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Side effect rates for Angeliq (Drospirenone / Estradiol)

363 From clinical trials of Angeliq / Postmenopausal hormone replacement (0.25/0.5 mg)
  • Gastrointestinal and abdominal pains
  • Headache
  • Vulvovaginal fungal infections
  • Breast pain
  • Nausea
  • Diarrhea
  • Leg or ankle swelling

Risks and Warnings for Angeliq (Drospirenone / Estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Angeliq (Drospirenone / Estradiol)

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  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
  • Angeliq (Drospirenone / Estradiol) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.