Prescription onlyClass: Women's health


(drospirenone / estradiol)

Prescription onlyClass: Women's health
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Relieves hot flashes and vaginal dryness due to menopause.

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Our bottom line

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

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  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
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  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
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Lowest price for 28 28 tablets of 0.5mg/1mg packages
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How it works

Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.

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Used for
Dosage forms
  • Pill

What to expect when you take Angeliq (drospirenone / estradiol) for Vaginal dryness and inflammation

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Side effect rates for Angeliq (drospirenone / estradiol)

363 From clinical trials of Angeliq / Menopausal symptoms (0.25/0.5 mg)
  • Stomach pain
  • Headache
  • Yeast infections
  • Breast pain
  • Nausea
  • Diarrhea
  • Swelling of arms and legs

Risks and Warnings for Angeliq (drospirenone / estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Angeliq (drospirenone / estradiol) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Angeliq (drospirenone / estradiol) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Angeliq (drospirenone / estradiol)

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