Prescription onlyNo lower cost generic available


(Drospirenone / Estradiol)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Relieves hot flashes and vaginal dryness due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Angeliq (Drospirenone / Estradiol) effectively relieves menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

  • Angeliq (Drospirenone / Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
  • More potential side effects since it exposes your whole body to two hormones, estrogen and drospirenone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Has a slightly higher risk of blood clots compared to other estrogen-progestin combination pills because of the type of progestin it contains (drospirenone).
  • Must be used carefully with any other medicine that can increase your potassium level.

Save on your next Angeliq (Drospirenone / Estradiol) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Angeliq (Drospirenone / Estradiol)

From clinical trials of Angeliq / Postmenopausal hormone replacement (0.25/0.5 mg)  ( 363)

  • Gastrointestinal and abdominal painsGastrointestinal and abdominal pains6% for Angeliq vs.3% for placebo
  • HeadacheHeadache6% for Angeliq vs.5% for placebo
  • Vulvovaginal fungal infectionsVulvovaginal fungal infections6% for Angeliq vs.1% for placebo
  • Breast painBreast pain3% for Angeliq vs.1% for placebo
  • NauseaNausea3% for Angeliq vs.1% for placebo
  • DiarrheaDiarrhea2% for Angeliq vs.1% for placebo
  • Leg or ankle swellingLeg or ankle swelling2% for Angeliq vs.1% for placebo

What to expect when you take Angeliq (Drospirenone / Estradiol)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • You can get some bleeding if you miss several doses in a row.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Angeliq (Drospirenone / Estradiol)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Angeliq (Drospirenone / Estradiol)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is X. It is advised that you: Unsafe
  • Upsides and downsides from our pharmacists
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).