Prescription onlyNo lower cost generic available


(Drospirenone / Estradiol)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
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Relieves hot flashes and vaginal dryness due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Angeliq (Drospirenone / Estradiol) effectively relieves menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

  • Angeliq (Drospirenone / Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
  • More potential side effects since it exposes your whole body to two hormones, estrogen and drospirenone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Has a slightly higher risk of blood clots compared to other estrogen-progestin combination pills because of the type of progestin it contains (drospirenone).
  • Must be used carefully with any other medicine that can increase your potassium level.

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  • (1) 28 tablets of 0.5mg/1mg package
  • Cost for (1) 28 tablets of 0.5mg/1mg package of Angeliq (Drospirenone / Estradiol) at pharmacies
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Side effects for Angeliq (Drospirenone / Estradiol)

From clinical trials of Angeliq / Postmenopausal hormone replacement (0.25/0.5 mg)  ( 363)

  • Gastrointestinal and abdominal painsGastrointestinal and abdominal pains6% for Angeliq vs.3% for placebo
  • HeadacheHeadache6% for Angeliq vs.5% for placebo
  • Vulvovaginal fungal infectionsVulvovaginal fungal infections6% for Angeliq vs.1% for placebo
  • Breast painBreast pain3% for Angeliq vs.1% for placebo
  • NauseaNausea3% for Angeliq vs.1% for placebo
  • DiarrheaDiarrhea2% for Angeliq vs.1% for placebo
  • Leg or ankle swellingLeg or ankle swelling2% for Angeliq vs.1% for placebo

What to expect when you take Angeliq (Drospirenone / Estradiol)

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Tips from our pharmacists
  • You can get some bleeding if you miss several doses in a row.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Angeliq (Drospirenone / Estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Angeliq (Drospirenone / Estradiol)

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The FDA category for this medication is X. It is advised that you: Unsafe
  • Upsides and downsides from our pharmacists
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).