Prescription onlyLower-cost generic availableClass: Neuro/psych

Antabuse 

(disulfiram)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats alcoholism.

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Our bottom line

While Antabuse (disulfiram) is a good way to help stop alcoholism, it works best if you're also seeing a therapist.

Price and discounts
Best available price for 30 (250mg) tablets of disulfiram

Upsides

  • Antabuse (disulfiram) is a first choice medicine for alcoholism.
  • You're less likely to start drinking again with Antabuse (disulfiram) than other medicines.

Downsides

  • Antabuse (disulfiram) can cause bad reactions to all types of alcohol, even in sauces or in medicines.
  • If you have diabetes, hypothyroidism, seizures, brain, liver or kidney damage, Antabuse (disulfiram) might not be safe for you to use.
How it works

Antabuse (disulfiram) is an aldehyde dehydrogenase inhibitor. It prevents your body from processing alcohol when you drink it and discourages you from drinking.

What to expect when you take Antabuse (disulfiram) for Alcoholism

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Side effect rates for Antabuse (disulfiram)

Risks and Warnings for Antabuse (disulfiram)

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    • Higher risk if:
    • Drinking alcohol while on Antabuse (disulfiram)

    Drinking alcohol while on Antabuse (disulfiram) can cause nausea, vomiting, bad headaches, flushing and shortness of breath. This usually lasts for 30 to 60 minutes. Also, you can still get this reaction for 2 weeks after you stop taking Antabuse (disulfiram). Never give Antabuse (disulfiram) to someone who's drunk, and especially do not give it to someone without their knowledge because it can be hard to tell if someone's drunk alcohol.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Antabuse (disulfiram)

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Pregnancy
Alcohol
  • Don't have any alcohol for at least 12 hours before you start taking Antabuse (disulfiram).
  • You might get a reaction with Antabuse (disulfiram) if you have any type of alcohol, even in medicines or in sauces containing alcohol.
  • If you try to drink alcohol while taking Antabuse (disulfiram), you might experience vomiting, bad headaches, flushing, nausea, and shortness of breath. This can happen for up to two weeks after you stop taking it.
  • Drinking alcohol while on Antabuse (disulfiram) can cause nausea, vomiting, bad headaches, flushing and shortness of breath. This usually lasts for 30 to 60 minutes. Also, you can still get this reaction for 2 weeks after you stop taking Antabuse (disulfiram). Never give Antabuse (disulfiram) to someone who's drunk, and especially do not give it to someone without their knowledge because it can be hard to tell if someone's drunk alcohol.
Kidneys and liver
  • If you have diabetes, hypothyroidism, seizures, brain, liver or kidney damage, Antabuse (disulfiram) might not be safe for you to use.
Pain
  • Antabuse (disulfiram) can damage your liver. Your doctor will do blood tests to check your liver while you're on Antabuse (disulfiram). Talk to your doctor right away if you get a high fever, abdominal pain or notice your skin or eyes turning yellow.