Prescription onlyLower-cost generic available

Arthrotec

(Diclofenac / Misoprostol)

  • Pill
  • Extended release
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Treats arthritis pain and swelling.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Arthrotec (Diclofenac / Misoprostol) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, it's recommended to limit the amount you take.

  • Clinical studies show that Arthrotec (Diclofenac / Misoprostol) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Can't be used in pregnant or breastfeeding women.
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.

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Side effects for Arthrotec (Diclofenac / Misoprostol)

From clinical trials of Arthrotec / Arthritis in people at risk for GI ulcers 

  • Abdominal painAbdominal pain21% for Arthrotec vs.0% for placebo
  • DiarrheaDiarrhea19% for Arthrotec vs.0% for placebo
  • IndigestionIndigestion14% for Arthrotec vs.0% for placebo
  • NauseaNausea11% for Arthrotec vs.0% for placebo
  • Digestive tract disorderDigestive tract disorder9% for Arthrotec vs.0% for placebo
  • Passing gasPassing gas9% for Arthrotec vs.0% for placebo

What to expect when you take Arthrotec (Diclofenac / Misoprostol)

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Tips from our pharmacists
  • Take with food to avoid getting diarrhea.
  • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in the legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Arthrotec (Diclofenac / Misoprostol).
  • Take Arthrotec (Diclofenac / Misoprostol) at the smallest dose possible for the shortest amount of time to lower your risk of a heart attack.
  • Don't give Arthrotec (Diclofenac / Misoprostol) to anyone that it's not prescribed to, especially women who are pregnant or are trying to become pregnant.

Risks and Warnings for Arthrotec (Diclofenac / Misoprostol)

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    • Higher risk if:
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking

    Arthrotec (Diclofenac / Misoprostol) can increase your chance of having blood clots, heart attack, or stroke. Take the lowest dose for the shortest time possible to lower your risk. Never take Arthrotec (Diclofenac / Misoprostol) during the first two weeks after having heart surgery.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Arthrotec (Diclofenac / Misoprostol)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • Tips from our pharmacists
  • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
Food
  • Tips from our pharmacists
  • Take with food to avoid getting diarrhea.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Risks from our pharmacists
  • Arthrotec (Diclofenac / Misoprostol), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Arthrotec (Diclofenac / Misoprostol) for long periods of time.
  • Always eat before taking, can upset an empty stomach. Effective on kidney infection pain, and offers partial relief to kidney stone pain
    Age: 24
    Gender: Woman
    Taken for: Kidney pain
    Duration taken: Two years or more