Prescription onlyLower-cost generic available

Arthrotec

(Diclofenac / Misoprostol)

Prescription onlyLower-cost generic available
  • Pill
  • Extended release
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Treats arthritis pain and swelling.

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Our bottom line

Arthrotec (Diclofenac / Misoprostol) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, it's recommended to limit the amount you take.

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Upsides

  • Clinical studies show that Arthrotec (Diclofenac / Misoprostol) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.

Downsides

  • Can't be used in pregnant or breastfeeding women.
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
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Side effect rates for Arthrotec (Diclofenac / Misoprostol)

From clinical trials of Arthrotec / Arthritis in people at risk for GI ulcers
  • Abdominal pain
  • Diarrhea
  • Indigestion
  • Nausea
  • Digestive tract disorder
  • Passing gas

Risks and Warnings for Arthrotec (Diclofenac / Misoprostol)

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    • Higher risk if:
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking

    Arthrotec (Diclofenac / Misoprostol) can increase your chance of having blood clots, heart attack, or stroke. Take the lowest dose for the shortest time possible to lower your risk. Never take Arthrotec (Diclofenac / Misoprostol) during the first two weeks after having heart surgery.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Arthrotec (Diclofenac / Misoprostol)

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Pregnancy
Alcohol
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
Food
  • Take with food to avoid getting diarrhea.
Kidneys and liver
  • Arthrotec (Diclofenac / Misoprostol), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Arthrotec (Diclofenac / Misoprostol) for long periods of time.
Pain
  • Can be used as needed to treat pain and swelling.
  • Can cause swelling in the legs, abdominal pain, constipation, diarrhea, and an upset stomach.