Prescription onlyLower-cost generic available

Arthrotec Alternatives

(Diclofenac / Misoprostol)

  • Pill
  • Extended release
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Compare Arthrotec (Diclofenac / Misoprostol) to alternatives

These medications are comparable to Arthrotec (Diclofenac / Misoprostol) or used for similar purposes.

Arthrotec
(Diclofenac / Misoprostol)

Advil
(Ibuprofen)

Aleve
(Naproxen)

Relafen
(Nabumetone)

Lodine
(Etodolac)

Celebrex
(Celecoxib)

Voltaren
(Diclofenac Sodium)

Treats arthritis pain and swelling. Arthrotec (Diclofenac / Misoprostol) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, it's recommended to limit the amount you take.Relieves pain, fever, and inflammation. Advil (Ibuprofen) works well for mild to moderate pain and inflammation, but it doesn't last as long as other NSAIDs.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Coming soon.Coming soon.Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Relieves pain and inflammation. Voltaren (Diclofenac Sodium) works well for pain and causes less upset stomach than other NSAIDs.
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Reviews & ratings
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Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Advil (Ibuprofen)
88%
12% vs. Arthrotec (Diclofenac / Misoprostol)
51%
49% vs. Arthrotec (Diclofenac / Misoprostol)
4%
4% vs. Arthrotec (Diclofenac / Misoprostol)
Reviews for Aleve (Naproxen)
78%
22% vs. Arthrotec (Diclofenac / Misoprostol)
46%
54% vs. Arthrotec (Diclofenac / Misoprostol)
5%
5% vs. Arthrotec (Diclofenac / Misoprostol)

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Celebrex (Celecoxib)
56%
44% vs. Arthrotec (Diclofenac / Misoprostol)
36%
64% vs. Arthrotec (Diclofenac / Misoprostol)
13%
13% vs. Arthrotec (Diclofenac / Misoprostol)
Reviews for Voltaren (Diclofenac Sodium)
73%
27% vs. Arthrotec (Diclofenac / Misoprostol)
68%
32% vs. Arthrotec (Diclofenac / Misoprostol)
9%
9% vs. Arthrotec (Diclofenac / Misoprostol)
Side effects
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren

The Arthrotec FDA package insert doesn’t have numbers about how common side effects are.

More about Arthrotec side effects »

We haven’t found good data for Ibuprofen side effects.

FDA side effect reports for Ibuprofen »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

We haven’t found good data for Relafen side effects.

FDA side effect reports for Relafen »

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Application site contact dermatitis 29%
  • Application site rash 29%
  • Dry skin (application site) 27%
  • Application site dry skin 15%
  • Application site rash 15%
  • Application site reaction 14%
  • Any side effect 14%
  • Application site exfoliation 11%
  • Application site pruritus 7%
  • Contact dermatitis (application site) 7%
More Voltaren side effects »
How it works
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
Arthrotec (Diclofenac / Misoprostol) contains two medications. Diclofenac stops the body from making chemicals that cause inflammation and pain. Misoprostol protects the stomach from irritation.Advil (Ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coming soon.Coming soon.Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Voltaren (Diclofenac Sodium) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prostaglandin E1 analog
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription or OTC
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription or OTC
Coming soon.
Coming soon.
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Available as
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Pill
  • Extended release
  • Pill
  • Chewable tablet
  • Oral suspension
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Cream, gel, or ointment
  • Eye drops
Used for (click to learn more)
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Osteoarthritis Rheumatoid arthritis
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
Risk factors for serious side effects
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Also taking an anticoagulant medication
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
  • Late pregnancy (more than 30 weeks)
Detailed Arthrotec (Diclofenac / Misoprostol) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take with food to avoid getting diarrhea.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent upset stomach.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent an upset stomach.
No specific food-related info.No specific food-related info.
  • Take it with a meal or a snack to prevent an upset stomach.
  • If taking Voltaren (Diclofenac Sodium) by mouth, take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Arthrotec (Diclofenac / Misoprostol), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Arthrotec (Diclofenac / Misoprostol) for long periods of time.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Can lower kidney function or cause permanent kidney damage. These problems are more likely the longer you take it.
  • Can affect your kidneys' ability to work as well.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Clinical studies show that Arthrotec (Diclofenac / Misoprostol) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Ibuprofen works as well as aspirin in treating pain and causes fewer stomach problems.
  • Ibuprofen works better than acetaminophen (Tylenol) at lowering fever and relieving sinus pain.
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
Coming soon.Coming soon.
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Works well to relieve pain and inflammation from osteoarthritis and rheumatoid arthritis.
  • Good for muscle aches and pains.
  • May treat arthritis pain better than other similar medicines (NSAIDs).
  • Can cause less upset stomach than other NSAIDs like ibuprofen (Advil).
  • It's also available as a gel that you put on your skin. If it's hard for you to swallow pills, this could be a good option.
  • If you're only using the gel, you won't have the same side effects that you would while taking Voltaren (Diclofenac Sodium) by mouth.
Downsides and risks
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Can't be used in pregnant or breastfeeding women.
  • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Ibuprofen doesn't work as long as other NSAIDs, so follow the package directions on how often you can take it.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
Coming soon.Coming soon.
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Can cause serious stomach problems like inflammation, ulcers, and bleeding. The chances that a stomach problem will occur is worse the longer you take this medication, but it can happen at any time while taking it.
  • Can lower kidney function or cause permanent kidney damage. These problems are more likely the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
Tips from our pharmacists for people taking the medication
ArthrotecIbuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Take with food to avoid getting diarrhea.
  • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in the legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Arthrotec (Diclofenac / Misoprostol).
  • Take Arthrotec (Diclofenac / Misoprostol) at the smallest dose possible for the shortest amount of time to lower your risk of a heart attack.
  • Don't give Arthrotec (Diclofenac / Misoprostol) to anyone that it's not prescribed to, especially women who are pregnant or are trying to become pregnant.
  • Take it with a meal or a snack to prevent upset stomach.
  • Starts relieving pain in 30 to 60 minutes.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Coming soon.Coming soon.
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • If taking Voltaren (Diclofenac Sodium) by mouth, take it with a meal or a snack to prevent an upset stomach.
  • Can cause stomach ulcers, especially if taking it by mouth often.
  • Can make you bruise or bleed more easily. You shouldn't take any other 'blood thinner' medications unless your doctor tells you it's safe.
  • Don't use it the first two weeks after a heart surgery.
  • Can affect your kidneys' ability to work as well.
  • If using the skin (topical) gel, use the dosing card it comes with to make sure you measure the correct dose. You also won't have many of the same side effects that you would if taking Voltaren (Diclofenac Sodium) by mouth.
Learn more
More about ArthrotecSide effectsReviews & ratingsAlternativesFDA package insert
More about IbuprofenSide effectsReviews & ratingsFDA package insert
More about NaproxenSide effectsReviews & ratingsFDA package insert
More about RelafenSide effectsReviews & ratingsFDA package insert
More about LodineSide effectsReviews & ratingsFDA package insert
More about CelebrexSide effectsReviews & ratingsFDA package insert
More about VoltarenSide effectsReviews & ratingsFDA package insert