Prescription onlyLower-cost generic availableClass: Pain

Arthrotec Alternatives

(diclofenac / misoprostol)

Prescription onlyLower-cost generic availableClass: Pain
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Compare Arthrotec (diclofenac / misoprostol) to alternatives

These medications are comparable to Arthrotec (diclofenac / misoprostol) or used for similar purposes.

Arthrotec
(diclofenac / misoprostol)

Advil
(ibuprofen)

Aleve
(naproxen)

Relafen
(nabumetone)

Lodine
(etodolac)

Celebrex
(celecoxib)

Cambia
(diclofenac)

Treats arthritis pain and swelling. Arthrotec (Diclofenac / Misoprostol) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, it's recommended to limit the amount you take.Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Coming soon.Coming soon.Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Relieves pain and inflammation. Cambia (diclofenac) works well for pain and is available in many different forms. If you have a history of heart problems or stomach bleeds, it may not be the best choice.
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Arthrotec (diclofenac / misoprostol)?
Worth itNot sureNot worth it
Reviews for ibuprofen
88%
+12% better vs. Arthrotec
52%
+15% better vs. Arthrotec
4%
+4% better vs. Arthrotec
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Naproxen
78%
+22% better vs. Arthrotec
48%
+19% better vs. Arthrotec
5%
+5% better vs. Arthrotec
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Relafen (nabumetone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Lodine (etodolac)?
Worth itNot sureNot worth it
Reviews for Celebrex
57%
+43% better vs. Arthrotec
38%
+29% better vs. Arthrotec
14%
+14% better vs. Arthrotec
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
Reviews for Voltaren
81%
+19% better vs. Arthrotec
76%
-9% worse vs. Arthrotec
5%
+5% better vs. Arthrotec
Have you used Cambia (diclofenac)?
Worth itNot sureNot worth it
Side effects
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Abdominal pain 21%
  • Diarrhea 19%
  • Dyspepsia 14%
  • Nausea 11%
  • GI disorders 9%
  • Flatulence 9%
More Arthrotec side effects »

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

We haven’t found good data for Relafen side effects.

FDA side effect reports for Relafen »

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Swelling 1%
  • Constipation 4%
  • Itching 1%
  • Gas 1%
  • Pain in limbs 2%
  • Indigestion 1%
More Voltaren side effects »
How it works
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
Arthrotec (Diclofenac / Misoprostol) contains two medications. Diclofenac stops the body from making chemicals that cause inflammation and pain. Misoprostol protects the stomach from irritation.Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coming soon.Coming soon.Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Cambia (diclofenac) is a non-steroidal anti-inflammatory drug (NSAID), which relieves pain by reducing the inflammation in your body.
Type of medication
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
Prescription onlyOver-the-counterPrescription or OTCPrescription onlyPrescription only
Available as
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Pill
  • Extended release
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Pill
  • Extended release
  • Pill
  • Pill
  • Injection
Used for
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
  • Osteoarthritis Rheumatoid Arthritis
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Arthrotec (diclofenac / misoprostol) risks & warnings »
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
Detailed Aleve (naproxen) risks & warnings »
    Coming soon.
      Coming soon.
      • Long-term use
      • History of heart disease
      • History of heart bypass surgery (coronary artery bypass graft/CABG)
      • Age 65 or older
      • History of GI bleed or peptic ulcer disease
      Detailed Celebrex (celecoxib) risks & warnings »
      • History of heart problems
      • Taking Cambia (diclofenac) for a long period of time
      • History of stomach bleeding
      • Age 60 or older
      • Taking aspirin, other NSAIDs, or blood thinners
      Detailed Cambia (diclofenac) risks & warnings »
      Pregnancy

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
      • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
      No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
      Food
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Take with food to avoid getting diarrhea.
      • Take it with food or milk to prevent stomach upset.
      • It needs to be taken with food or millk to avoid getting an upset stomach.
      • Take it with a meal or a snack to prevent an upset stomach.
      • It needs to be taken with food to avoid getting an upset stomach.
      No food related info.No food related info.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Take with food or milk to prevent upset stomach.
      Kidneys and liver
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Arthrotec (Diclofenac / Misoprostol), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Arthrotec (Diclofenac / Misoprostol) for long periods of time.
      • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
      • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
      No kidneys and liver related info.No kidneys and liver related info.
      • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Cambia (diclofenac) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Cambia (diclofenac).
      • Can affect how your kidneys work.
      • Can lower kidney function or cause permanent kidney damage.
      Pain
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Can cause swelling in the legs, abdominal pain, constipation, diarrhea, and an upset stomach.
      • Can be used as needed to treat pain and swelling.
      • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
      • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
      • Starts relieving pain in 30 to 60 minutes.
      • Works well to relieve pain, swelling, and fevers.
      No pain related info.No pain related info.
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Cambia (diclofenac) can cause stomach bleeding which can be dangerous. If you notice blood in your vomit or your stool has bright red blood or looks like black coffee grounds, or if you have pain in your stomach that doesn't go away, talk to your doctor right away.
      • Works well to relieve muscle ache and pain caused by inflammation.
      • May need to be taken two or three-times daily for maximum pain relief.
      Upsides and benefits
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Clinical studies show that Arthrotec (Diclofenac / Misoprostol) is better at relieving arthritis pain than acetaminophen (Tylenol).
      • Can be used as needed to treat pain and swelling.
      • Available as a generic.
      • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
      • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
      • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
      • Advil (ibuprofen) causes less stomach problems than its alternatives.
      • It comes in different flavored liquid forms that makes it easy for children to take.
      • Works well to relieve pain, swelling, and fevers.
      • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
      • Lasts longer than Ibuprofen, so you can take it less often.
      • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
      • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
      Coming soonComing soon
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
      • Lasts longer than Ibuprofen.
      • Works well to relieve muscle ache and pain caused by inflammation.
      • Minimal risk for addiction unlike narcotics.
      • Available in gel or powder packets if you have difficulty taking the pill.
      • Most forms are available as generic.
      Downsides and risks
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Can't be used in pregnant or breastfeeding women.
      • You should avoid alcohol while on Arthrotec (Diclofenac / Misoprostol) since it can increase your risk of stomach issues.
      • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
      • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
      • It needs to be taken with food or millk to avoid getting an upset stomach.
      • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
      • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
      • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
      • It needs to be taken with food to avoid getting an upset stomach.
      • Can't be taken by pregnant women.
      • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
      • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
      Coming soonComing soon
      • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
      • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Not for chronic, daily use because of increased side-effects.
      • May need to be taken two or three-times daily for maximum pain relief.
      • Can cause serious stomach problems like inflammation, ulcers, and bleeding.
      • Can raise your risk of having blood clots, heart attack, or stroke.
      • Can lower kidney function or cause permanent kidney damage.
      Tips from our pharmacists for people taking the medication
      ArthrotecibuprofenNaproxenRelafenLodineCelebrexVoltaren
      • Take with food to avoid getting diarrhea.
      • Don't drink alcohol while on Arthrotec (Diclofenac / Misoprostol).
      • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
      • Can cause swelling in the legs, abdominal pain, constipation, diarrhea, and an upset stomach.
      • Don't take antacids with magnesium since they can interact with Arthrotec (Diclofenac / Misoprostol).
      • Take Arthrotec (Diclofenac / Misoprostol) at the smallest dose possible for the shortest amount of time to lower your risk of a heart attack.
      • Don't give Arthrotec (Diclofenac / Misoprostol) to anyone that it's not prescribed to, especially women who are pregnant or are trying to become pregnant.
      • Starts working in about 30 to 60 minutes.
      • Take it with food or milk to prevent stomach upset.
      • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
      • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
      • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
      • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
      • Starts relieving pain in 30 to 60 minutes.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      Coming soonComing soon
      • Starts working in 1 to 3 hours.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Take with food or milk to prevent upset stomach.
      • Can cause stomach ulcers especially if you've had ulcers before.
      • Can thin your blood. Avoid taking this with other blood thinners such as aspirin or warfarin unless your doctor says it's safe.
      • Don't use if you've recently had open heart surgery.
      • Can affect how your kidneys work.
      • Talk to your doctor if you're having trouble taking this medicine. It's available in other forms (gel, delayed-release pill, extended-release pill) that may have less side-effects.
      Learn more
      More about ArthrotecSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Arthrotec (diclofenac / misoprostol)?
      Worth itNot sureNot worth it
      More about ibuprofenSide effectsReviews & ratingsFDA package insert
      Have you used Advil (ibuprofen)?
      Worth itNot sureNot worth it
      More about NaproxenSide effectsReviews & ratingsFDA package insert
      Have you used Aleve (naproxen)?
      Worth itNot sureNot worth it
      More about RelafenSide effectsReviews & ratingsFDA package insert
      Have you used Relafen (nabumetone)?
      Worth itNot sureNot worth it
      More about LodineSide effectsReviews & ratingsFDA package insert
      Have you used Lodine (etodolac)?
      Worth itNot sureNot worth it
      More about CelebrexSide effectsReviews & ratingsFDA package insert
      Have you used Celebrex (celecoxib)?
      Worth itNot sureNot worth it
      More about VoltarenSide effectsReviews & ratingsFDA package insert
      Have you used Cambia (diclofenac)?
      Worth itNot sureNot worth it