Prescription onlyLower-cost generic available



Prescription onlyLower-cost generic available
  • Pill
  • Extended release
  • Enema
  • Suppository
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Treats inflammatory bowel disease.

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Our bottom line

Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.

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  • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
  • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
  • Available in tablets, capsules, enemas, and suppositories.
  • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).


  • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
  • Doesn't work well for severe colon inflammation.
  • You may need to take Lialda (Mesalamine) three or four times a day.
  • Not a good option if you have kidney disease.

What to expect when you take Lialda (Mesalamine) for Ulcerative colitis

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Side effect rates for Lialda (Mesalamine)

239 From clinical trials of Asacol / Ulcerative colitis
  • Headache
  • Abdominal pain
  • Eructation
  • Pain
  • Nausea
  • Sore throat
  • Dizziness
  • Muscle weakness
  • Diarrhea
  • Back pain

Risks and Warnings for Lialda (Mesalamine)

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    • Higher risk if:
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy

    Rarely, Lialda (Mesalamine) can cause serious allergic reactions. These reactions can make it difficult to breathe or cause a severe rash that can be life-threatening. Stop taking Lialda (Mesalamine) and report any skin rash, fever, swelling, or trouble breathing to a doctor right away.

Common concerns from people taking Lialda (Mesalamine)

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  • Large pills that are not difficult to take. Take just before meals.
  • Best to take it all at once with your biggest meal of the day
Kidneys and liver
  • Not a good option if you have kidney disease.
  • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
  • Rarely, Lialda (Mesalamine) can cause liver injury, hepatitis, and liver failure. Let your doctor know and get medical attention if you notice yellowing skin or eyes.