Prescription onlyLower-cost generic availableDrug class: Gastrointestinal

Lialda Alternatives

(Mesalamine)

Prescription onlyLower-cost generic availableDrug class: Gastrointestinal
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Compare Lialda (Mesalamine) to alternatives

These medications are comparable to Lialda (Mesalamine) or used for similar purposes.

Lialda
(Mesalamine)

Colazal
(Balsalazide)

Azulfidine
(Sulfasalazine)

Treats inflammatory bowel disease. Lialda (Mesalamine) is an effective first-line medicine for inflammatory bowel disease. There isn't a generic version and you'll have to take it multiple times a day.Coming soon.Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.
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Reviews & ratings
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Have you used Lialda (Mesalamine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Colazal (Balsalazide)?
Worth itNot sureNot worth it

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Have you used Azulfidine (Sulfasalazine)?
Worth itNot sureNot worth it
Side effects
AsacolColazalSulfasalazine
  • Abdominal pain 4%
  • Eructation 1%
  • Pain 6%
  • Sore throat 2%
  • Back pain 2%
More Asacol side effects »

We haven’t found good data for Colazal side effects.

FDA side effect reports for Colazal »

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
How it works
AsacolColazalSulfasalazine
Lialda (Mesalamine) is an anti-inflammatory medication. Researchers don't know exactly how Lialda (Mesalamine) works in the colon, but it seems to lower the chemicals in the body that cause inflammation.Coming soon.Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.
Type of medication
AsacolColazalSulfasalazine
Prescription only
Prescription only
Available as
AsacolColazalSulfasalazine
  • Pill
  • Extended release
  • Enema
  • Suppository
  • Pill
  • Pill
  • Extended release
Used for
AsacolColazalSulfasalazine
  • Ulcerative Colitis Mild To Moderate
Risk factors for serious side effects
AsacolColazalSulfasalazine
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Liver problems
  • Age 65 or older
  • Liver problems
  • Taking Lialda (Mesalamine) at the start of treatment
Detailed Lialda (Mesalamine) risks & warnings »
Coming soon.
          Detailed Azulfidine (Sulfasalazine) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Food
          AsacolColazalSulfasalazine
          No food related info.No food related info.
          • Swallow tablets whole, and take after a meal with a full glass of water.
          Kidneys and liver
          AsacolColazalSulfasalazine
          • Not a good option if you have kidney disease.
          • Lialda (Mesalamine) is broken down by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need to take a different dose of the medication.
          • Rarely, Lialda (Mesalamine) can cause liver injury, hepatitis, and liver failure. Let your doctor know and get medical attention if you notice yellowing skin or eyes.
          No kidneys and liver related info.
          • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
          • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
          Upsides and benefits
          AsacolColazalSulfasalazine
          • Effective first-line medication for treating and lowering the symptoms of mild inflammatory bowel disease.
          • About half the people who have mild to moderate colon inflammation and take Lialda (Mesalamine) will see improvement.
          • Available in tablets, capsules, enemas, and suppositories.
          • Certain forms of Lialda (Mesalamine) can be used during pregnancy. Talk to your doctor if you're pregnant, or plan on becoming pregnant, and you want to take Lialda (Mesalamine).
          Coming soon
          • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
          • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
          Downsides and risks
          AsacolColazalSulfasalazine
          • No generic versions are available for the tablets, capsules, and suppositories (meaning it could be somewhat expensive).
          • Doesn't work well for severe colon inflammation.
          • You may need to take Lialda (Mesalamine) three or four times a day.
          • Not a good option if you have kidney disease.
          Coming soon
          • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
          • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
          • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
          • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
          Tips from our pharmacists for people taking the medication
          AsacolColazalSulfasalazine
          • Don't take Lialda (Mesalamine) if you're allergic to aspirin. Talk to your doctor or pharmacist about any drug allergies you have before starting Lialda (Mesalamine).
          • Taking antacids with Lialda (Mesalamine) can make your inflammation worse. Talk to your doctor before you make any changes.
          • You can sunburn more easily when taking Lialda (Mesalamine). Use sunscreen and protective clothing when you go outdoors.
          • Don't break, chew, or crush the tablets because they're coated and won't work as well.
          • The suppositories should be kept in for at least 1 to 3 hours to get the most benefit.
          Coming soon
          • Don't use if you are allergic to sulfa drugs or aspirin.
          • Swallow tablets whole, and take after a meal with a full glass of water.
          • Drink at least six glasses of water daily while on this.
          • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
          • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
          • Can cause an orange color in your urine or skin.
          Learn more
          More about AsacolSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Lialda (Mesalamine)?
          Worth itNot sureNot worth it
          More about ColazalSide effectsReviews & ratingsFDA package insert
          Have you used Colazal (Balsalazide)?
          Worth itNot sureNot worth it
          More about SulfasalazineSide effectsReviews & ratingsFDA package insert
          Have you used Azulfidine (Sulfasalazine)?
          Worth itNot sureNot worth it