Prescription onlyNo lower cost generic available


(Efavirenz / Emtricitabine / Tenofovir)

Prescription onlyNo lower cost generic available
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Treats HIV infection.

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Our bottom line

Atripla (Efavirenz / Emtricitabine / Tenofovir) is effective at treating HIV infection and it’s easier to remember to take just one pill instead of three separate medicines.

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  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is very effective at treating HIV infection.
  • Contains three medications in one tablet, so it’s convenient to take.
  • Generally well-tolerated (not as many side effects) compared to other HIV drugs.


  • Important to take at the same time every day to make sure the virus doesn’t become resistant to the medication.
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (Efavirenz / Emtricitabine / Tenofovir) and for 12 weeks after stopping Atripla (Efavirenz / Emtricitabine / Tenofovir).
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Side effect rates for Atripla (Efavirenz / Emtricitabine / Tenofovir)

257 From clinical trials of Atripla / HIV
  • Diarrhea
  • Fatigue
  • Nausea
  • Low mood disorder
  • Sinus inflammation
  • Ear, nose, or throat infection
  • Dizziness
  • Rash event
  • Headache
  • Anxiety

Risks and Warnings for Atripla (Efavirenz / Emtricitabine / Tenofovir)

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    • Higher risk if:
    • History of mental illness.
    • History of using recreational drugs.

    Atripla (Efavirenz / Emtricitabine / Tenofovir) has been associated with depression, thoughts of suicide, aggression, and psychosis. If your mood starts to change while taking Atripla (Efavirenz / Emtricitabine / Tenofovir), let your doctor know. If you start thinking about wanting to harm yourself, seek medical attention immediately.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Atripla (Efavirenz / Emtricitabine / Tenofovir)

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Kidneys and liver
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Atripla (Efavirenz / Emtricitabine / Tenofovir). It may not be a good choice for people with liver problems.
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of Atripla (Efavirenz / Emtricitabine / Tenofovir). Your doctor must continually monitor the function of your kidneys while you are taking Atripla (Efavirenz / Emtricitabine / Tenofovir).
  • You can experience some central nervous system side effects when starting Atripla (Efavirenz / Emtricitabine / Tenofovir), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Atripla (Efavirenz / Emtricitabine / Tenofovir) at bedtime will help lower the risk of experiencing these side effects. If these symptoms don't go away and it bothers you, let your doctor know.