Prescription onlyClass: Infection


(efavirenz / emtricitabine / tenofovir)

Prescription onlyClass: Infection
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Treats HIV infection.

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Our bottom line

Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.


  • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.


  • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
How it works

Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.

What to expect when you take Atripla (efavirenz / emtricitabine / tenofovir) for HIV treatment

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Side effect rates for Atripla (efavirenz / emtricitabine / tenofovir)

257 From clinical trials of Atripla / HIV treatment
  • Diarrhea
  • Low mood disorder
  • Fatigue
  • Nausea
  • Sinus inflammation
  • Ear, nose, or throat infection
  • Dizziness
  • Rash event
  • Headache
  • Anxiety

Risks and Warnings for Atripla (efavirenz / emtricitabine / tenofovir)

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    • Higher risk if:
    • Liver disease
    • Women
    • Obesity

    Atripla (efavirenz / emtricitabine / tenofovir) can cause this rare but life-threatening condition. Symptoms include difficulty breathing, nausea, vomiting, right sided stomach pain, and dark urine . This is a medical emergency and you should get help right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Atripla (efavirenz / emtricitabine / tenofovir)

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Kidneys and liver
  • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.