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Atripla

(Efavirenz / Emtricitabine / Tenofovir)

  • Pill
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Treats HIV infection.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Atripla (Efavirenz / Emtricitabine / Tenofovir) is effective at treating HIV infection and it’s easier to remember to take just one pill instead of three separate medicines.

  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is very effective at treating HIV infection.
  • Contains three medications in one tablet, so it’s convenient to take.
  • Generally well-tolerated (not as many side effects) compared to other HIV drugs.
  • Important to take at the same time every day to make sure the virus doesn’t become resistant to the medication.
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (Efavirenz / Emtricitabine / Tenofovir) and for 12 weeks after stopping Atripla (Efavirenz / Emtricitabine / Tenofovir).

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Side effects for Atripla (Efavirenz / Emtricitabine / Tenofovir)

From clinical trials of Atripla / HIV ( 257)

  • DiarrheaDiarrhea9% for Atripla vs.0% for placebo
  • Low mood disorderLow mood disorder9% for Atripla vs.0% for placebo
  • FatigueFatigue9% for Atripla vs.0% for placebo
  • NauseaNausea9% for Atripla vs.0% for placebo
  • Sinus inflammationSinus inflammation8% for Atripla vs.0% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection8% for Atripla vs.0% for placebo
  • DizzinessDizziness8% for Atripla vs.0% for placebo
  • Rash eventRash event7% for Atripla vs.0% for placebo
  • HeadacheHeadache6% for Atripla vs.0% for placebo
  • AnxietyAnxiety5% for Atripla vs.0% for placebo

What to expect when you take Atripla (Efavirenz / Emtricitabine / Tenofovir)

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Tips from our pharmacists
  • Take at bedtime on an empty stomach to lower possible side effects.
  • Take at the same time every day.
  • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
  • Let your doctor know if you start to get a rash.
  • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.

Risks and Warnings for Atripla (Efavirenz / Emtricitabine / Tenofovir)

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    • Higher risk if:
    • History of mental illness.
    • History of using recreational drugs.

    Atripla (Efavirenz / Emtricitabine / Tenofovir) has been associated with depression, thoughts of suicide, aggression, and psychosis. If your mood starts to change while taking Atripla (Efavirenz / Emtricitabine / Tenofovir), let your doctor know. If you start thinking about wanting to harm yourself, seek medical attention immediately.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Atripla (Efavirenz / Emtricitabine / Tenofovir)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Risks from our pharmacists
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can damage your liver and is not recommended if you have severe liver disease. Try to limit or avoid alcohol to reduce this risk. Call your doctor right away if you start to have clay-colored stools, yellowing of the eyes or skin, dark urine, stomach pain, or if you are eating less than usual without trying to.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
  • Risks from our pharmacists
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Atripla (Efavirenz / Emtricitabine / Tenofovir). It may not be a good choice for people with liver problems.
  • Atripla (Efavirenz / Emtricitabine / Tenofovir) is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of Atripla (Efavirenz / Emtricitabine / Tenofovir). Your doctor must continually monitor the function of your kidneys while you are taking Atripla (Efavirenz / Emtricitabine / Tenofovir).
Sex
  • Tips from our pharmacists
  • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
Sleep
  • Tips from our pharmacists
  • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
  • Risks from our pharmacists
  • You can experience some central nervous system side effects when starting Atripla (Efavirenz / Emtricitabine / Tenofovir), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Atripla (Efavirenz / Emtricitabine / Tenofovir) at bedtime will help lower the risk of experiencing these side effects. If these symptoms don't go away and it bothers you, let your doctor know.