Prescription onlyNo lower cost generic available

Atripla Alternatives

(Efavirenz / Emtricitabine / Tenofovir)

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Compare Atripla (Efavirenz / Emtricitabine / Tenofovir) to alternatives

These medications are comparable to Atripla (Efavirenz / Emtricitabine / Tenofovir) or used for similar purposes.

Atripla
(Efavirenz / Emtricitabine / Tenofovir)

Stribild
(Elvitegravir / Cobicistat / Emtricitabine / Tenofovir)

Complera
(Emtricitabine / Rilpivirine / Tenofovir)

Epzicom
(Abacavir / Lamivudine)

Truvada
(Emtricitabine / Tenofovir)

Prezista
(Darunavir)

Isentress
(Raltegravir)

Treats HIV infection. Atripla (Efavirenz / Emtricitabine / Tenofovir) is effective at treating HIV infection and it’s easier to remember to take just one pill instead of three separate medicines.Coming soon.Coming soon.Coming soon.Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.Coming soon.Works with other medicines to treat HIV infection. This is the first medication approved as an Integrase Inhibitor (InSTI), so it may be a great, but somewhat expensive, option for people who have already tried other drugs and need another option.
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Reviews & ratings
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Side effects
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress

The Atripla FDA package insert doesn’t have numbers about how common side effects are.

More about Atripla side effects »

We haven’t found good data for Stribild side effects.

FDA side effect reports for Stribild »

We haven’t found good data for Complera side effects.

FDA side effect reports for Complera »

We haven’t found good data for Epzicom side effects.

FDA side effect reports for Epzicom »
  • > 5% bone mineral density loss 7%
  • Abdominal pain 2%
  • Secondary syphilis 2%
  • Headache 1%
  • Bone fractures 1%
  • Weight decreased 1%
  • Syphilis 1%
More Truvada side effects »

We haven’t found good data for Prezista side effects.

FDA side effect reports for Prezista »

We haven’t found good data for Isentress side effects.

FDA side effect reports for Isentress »
How it works
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
Atripla (Efavirenz / Emtricitabine / Tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs: tenofovir and emtricitabine (two nucleoside reverse transcriptase inhibitors) and efavirenz (a non-nucleoside reverse transcriptase inhibitor). It prevents the HIV-1 virus from multiplying and producing new viruses.Coming soon.Coming soon.Coming soon.Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.Coming soon.Isentress stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
Antiretroviral
Non-nucleoside reverse transcriptase inhibitor (NNRTI)
Antiretrovira
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Coming soon.Prescription only
Coming soon.
Coming soon.
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)
Prescription only
Coming soon.
Coming soon.Prescription only
Available as
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
  • HIV infection
  • HIV infection
  • HIV infection
  • HIV infection
  • HIV infection
Risk factors for serious side effects
AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
  • History of mental illness.
  • History of using recreational drugs.
  • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) for the first few weeks.
  • Taking alcohol or other drugs that also affect your nervous system.
  • Prior bone fractures
  • Osteoporosis
  • Women
  • Obesity
  • Liver disease
  • History of liver disease
  • Taking alcohol or other drugs that can damage the liver.
  • Infected with hepatitis B.
  • Not taking Atripla (Efavirenz / Emtricitabine / Tenofovir) regularly
  • History of seizures.
      • Starting Atripla (Efavirenz / Emtricitabine / Tenofovir) in the first two weeks.
        • Kidney damage
        Detailed Atripla (Efavirenz / Emtricitabine / Tenofovir) risks & warnings »
        Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
        Pregnancy category
        AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) can damage your liver and is not recommended if you have severe liver disease. Try to limit or avoid alcohol to reduce this risk. Call your doctor right away if you start to have clay-colored stools, yellowing of the eyes or skin, dark urine, stomach pain, or if you are eating less than usual without trying to.
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
        • Take Isentress with or without food.
        Kidneys and liver
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Atripla (Efavirenz / Emtricitabine / Tenofovir). It may not be a good choice for people with liver problems.
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of Atripla (Efavirenz / Emtricitabine / Tenofovir). Your doctor must continually monitor the function of your kidneys while you are taking Atripla (Efavirenz / Emtricitabine / Tenofovir).
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        • Can cause unusual dreams, or kidney or liver damage.
        • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
        No specific sex-related info.No specific sex-related info.No specific sex-related info.
        • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
        • You can experience some central nervous system side effects when starting Atripla (Efavirenz / Emtricitabine / Tenofovir), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Atripla (Efavirenz / Emtricitabine / Tenofovir) at bedtime will help lower the risk of experiencing these side effects. If these symptoms don't go away and it bothers you, let your doctor know.
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) is very effective at treating HIV infection.
        • Contains three medications in one tablet, so it’s convenient to take.
        • Generally well-tolerated (not as many side effects) compared to other HIV drugs.
        Coming soon.Coming soon.Coming soon.
        • First-line treatment for preventing HIV infection in combination with other HIV medications.
        • Only has to be taken once a day.
        • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
        • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
        Coming soon.
        • If having difficulty swallowing the tablet, consider the chewable tablet or oral suspension.
        • Only one tablet taken two times a day.
        • Can be used for kids 4 weeks and older.
        • May be helpful if other HIV drugs have stopped working since Isentress works differently than most HIV drugs.
        Downsides and risks
        AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
        • Important to take at the same time every day to make sure the virus doesn’t become resistant to the medication.
        • Atripla (Efavirenz / Emtricitabine / Tenofovir) can cause kidney damage, increase your risk of depression, and shouldn't be taken if you have a history of seizures or osteoporosis.
        • Women should avoid becoming pregnant while taking Atripla (Efavirenz / Emtricitabine / Tenofovir) and for 12 weeks after stopping Atripla (Efavirenz / Emtricitabine / Tenofovir).
        Coming soon.Coming soon.Coming soon.
        • Has to be taken at the same time every day or your body can become resistant to the medication.
        • Can't be taken on its own to treat HIV.
        • Can cause unusual dreams, or kidney or liver damage.
        • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
        • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
        Coming soon.
        • Tablets, chewable tablets, and the oral suspension all have different doses, so talk to your doctor if you want to switch from one to another.
        • The oral suspension has to be taken within 30 minutes of mixing it.
        • Avoid taking antacids that contain aluminum and/or magnesium while taking Isentress.
        • Let your doctor know right away if while taking Isentress you begin to feel unexplained muscle pain.
        Tips from our pharmacists for people taking the medication
        AtriplaStribildCompleraEpzicomTruvadaPrezistaIsentress
        • Take at bedtime on an empty stomach to lower possible side effects.
        • Take at the same time every day.
        • Can cause stomach upset, headache, nausea, difficulty sleeping, vivid dreams, or depression.
        • Let your doctor know if you start to get a rash.
        • Practice safe sex since Atripla (Efavirenz / Emtricitabine / Tenofovir) won't cure HIV or prevent it from being passed on to other people.
        Coming soon.Coming soon.Coming soon.
        • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
        • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
        • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
        • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
        Coming soon.
        • Set two times during the day, one in the morning and one in the evening that you will remember to take Isentress.
        • Take Isentress with or without food.
        • Isentress can make you tired, so avoid other medications or drinks that will add to the problem.
        • If being used for kids, the dose of Isentress will continue to change as they grow, so keep in touch with their doctor.
        Learn more
        More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
        More about StribildSide effectsReviews & ratingsFDA package insert
        More about CompleraSide effectsReviews & ratingsFDA package insert
        More about EpzicomSide effectsFDA package insert
        More about TruvadaSide effectsReviews & ratingsFDA package insert
        More about PrezistaSide effectsFDA package insert
        More about IsentressSide effectsReviews & ratingsFDA package insert