Prescription onlyClass: Infection

Atripla Alternatives

(efavirenz / emtricitabine / tenofovir)

Prescription onlyClass: Infection
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Compare Atripla (efavirenz / emtricitabine / tenofovir) to alternatives

These medications are comparable to Atripla (efavirenz / emtricitabine / tenofovir) or used for similar purposes.

Atripla
(efavirenz / emtricitabine / tenofovir)

Stribild
(elvitegravir / cobicistat / emtricitabine / tenofovir)

Complera
(emtricitabine / rilpivirine / tenofovir)

Truvada
(emtricitabine / tenofovir)

Emtriva
(emtricitabine)

Viread
(tenofovir)

Sustiva
(efavirenz)

Treats HIV infection. Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.Coming soon.Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.Works with other medicines to treat HIV infection. Emtriva (emtricitabine) is a first-line and commonly used drug that is taken in combination with other HIV medications to treat or prevent HIV.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. tenofovir can be a good choice to take within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class. It may not be the best choice though for people with kidney problems.Works with other medicines to treat HIV infection. Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.
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Reviews & ratings
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Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
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Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
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Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
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Reviews for Truvada
100%
Same vs. Atripla
94%
+6% better vs. Atripla
0%
Same vs. Atripla
Have you used Truvada (emtricitabine / tenofovir)?
Worth itNot sureNot worth it

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Have you used Emtriva (emtricitabine)?
Worth itNot sureNot worth it

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Have you used Viread (tenofovir)?
Worth itNot sureNot worth it

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Have you used Sustiva (efavirenz)?
Worth itNot sureNot worth it
Side effects
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
  • Diarrhea 9%
  • Low mood disorder 9%
  • Fatigue 9%
  • Nausea 9%
  • Sinus inflammation 8%
  • Ear, nose, or throat infection 8%
  • Dizziness 8%
  • Rash event 7%
  • Headache 6%
  • Anxiety 5%
More Atripla side effects »

We haven’t found good data for Stribild side effects.

FDA side effect reports for Stribild »
  • Headache 2%
  • Depressive disorders 2%
  • Sleep difficulty 2%
More Complera side effects »
  • > 5% bone mineral density loss 7%
  • Headache 1%
  • Syphilis 1%
  • Secondary syphilis 2%
  • Abdominal pain 2%
More Truvada side effects »
  • Diarrhea 23%
  • Nasal stuffiness/runniness (rhinitis) 18%
  • Nausea 18%
  • Rash 17%
  • Physical weakness and/or lack of energy 16%
  • Increased cough 14%
  • Headache 13%
  • Vomiting 9%
  • Abdominal pain 8%
  • Sleep difficulty 7%
More Emtriva side effects »

We haven’t found good data for Viread side effects.

FDA side effect reports for Viread »
  • Skin rash 16%
  • Diarrhea 14%
  • Pain 13%
  • Nausea 10%
  • Dizziness 9%
  • Itching 9%
  • Fatigue 8%
  • Headache 8%
More Sustiva side effects »
How it works
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Coming soon.Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.Emtriva (emtricitabine) is a Nucleoside reverse transcriptase inhibitor (NRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.tenofovir stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.Sustiva (efavirenz) is a Non-Nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.
Type of medication
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
Used for
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
  • HIV Infection
  • HIV Infection
Risk factors for serious side effects
AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Atripla (efavirenz / emtricitabine / tenofovir) risks & warnings »
    Coming soon.
    • Liver disease
    • Women
    • Obesity
    • Hepatitis B Virus infection
    • History of mental health problems
    Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
    • Infection with chronic hepatitis B and stopping Truvada (Emtricitabine / Tenofovir)
    • Taking high dose anti-inflammatory drugs (NSAIDs)
    • Undiscovered HIV infection
    Detailed Truvada (emtricitabine / tenofovir) risks & warnings »
    • Liver disease
    • Women
    • Obesity
    • Hepatitis B Virus infection
    • HIV
    Detailed Emtriva (emtricitabine) risks & warnings »
    • Women
    • Obesity
    • Liver disease
    • Kidney damage
    • Prior bone fractures
    Detailed Viread (tenofovir) risks & warnings »
    • Starting Sustiva (efavirenz) for the first few weeks.
    • Taking alcohol or other drugs that also affect your nervous system
    • HIV treatment
    • History of liver damage
    • Alcohol intake
    Detailed Sustiva (efavirenz) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Food
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    No food related info.No food related info.No food related info.No food related info.
    • Taken with or without food once a day.
    • Emtriva (emtricitabine) should be taken at the same time everyday, with or without food.
    No food related info.No food related info.
    Kidneys and liver
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
    No kidneys and liver related info.
    • Not recommended for patients with kidney damage.
    • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
    • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
    • Can cause unusual dreams, or kidney or liver damage.
    • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
    • Before starting Truvada (Emtricitabine / Tenofovir), your doctor will test you for hepatitis B to make sure you're not infected. People who've stopped Truvada (Emtricitabine / Tenofovir) and had chronic hepatitis B have suffered from liver damage and failure.
    • People on Truvada (Emtricitabine / Tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
    • Patients with kidney damage will need to be closely monitored by their doctors in order to provide an appropriate dose.
    • The dose of Emtriva (emtricitabine) should be adjusted if you have poor kidney health. Your doctor will provide lab tests to ensure you are taking the appropriate dose. Be sure to attend your scheduled doctor and lab appointments in order to make sure that Emtriva (emtricitabine) is working well and safely for you.
    • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
    • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
    • tenofovir can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use tenofovir. It may not be a good choice for people with liver problems.
    • Severe worsening of Hepatitis B has been seen in patients who have stopped taking tenofovir. Liver function should be closely watched in people who have both HIV and HBV.
    • tenofovir is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of tenofovir. Your doctor must continually monitor the function of your kidneys while you are taking tenofovir.
    • Can be used in patients with mild to moderate kidney damage.
    • Liver damage has been reported in patients who use Sustiva (efavirenz). Your doctor might do blood tests to check your liver regularly. If you notice yellowing of the eyes or the skin, or dark urine, talk to your doctor right away.
    Sleep
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
    • Some patients experience central nervous system side effects when starting Sustiva (efavirenz), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Sustiva (efavirenz) at bedtime will help lower the risk of experiencing these side effects. These symptoms are common in the first few weeks of starting treatment and usually go away. If symptoms don't improve or are preventing you from taking your medications regularly, let your doctor know.
    Upsides and benefits
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    Coming soon
    • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
    • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
    • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
    • First-line treatment for preventing HIV infection in combination with other HIV medications.
    • Only has to be taken once a day.
    • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
    • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
    • Emtriva (emtricitabine) is a first-line drug option used in combination with other HIV medications to treat HIV.
    • Taken with or without food once a day.
    • Emtriva (emtricitabine) is available in many combination tablets if you are looking to lower the number of pills you need to take daily for HIV treatment.
    • Emtriva (emtricitabine) is available as a capsule as well as liquid form.
    • Take tenofovir once a day, with or without food.
    • For people who can't swallow the tablet, take the powder instead.
    • tenofovir is used for HIV in kids 2 years and older, and chronic hepatitis B in kids 12 years and older.
    • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
    • Only taken once daily.
    • Sustiva (efavirenz) is available in combination tablets.
    • Can be used in patients with mild to moderate kidney damage.
    • Can be used in children who are at least 3 months old.
    Downsides and risks
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
    • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
    • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
    Coming soon
    • Must be taken with a light meal which includes fat.
    • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
    • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
    • Not recommended for patients with kidney damage.
    • Can weaken your bones.
    • Has to be taken at the same time every day or your body can become resistant to the medication.
    • Can't be taken on its own to treat HIV.
    • Can cause unusual dreams, or kidney or liver damage.
    • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
    • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
    • Patients with kidney damage will need to be closely monitored by their doctors in order to provide an appropriate dose.
    • Cannot be used by itself to treat or prevent HIV infection.
    • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
    • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
    • Not suggested for women who plan on becoming pregnant.
    • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
    • Cannot be taken alone for treatment of HIV.
    Tips from our pharmacists for people taking the medication
    AtriplaStribildCompleraTruvadaEmtrivaVireadSustiva
    • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Atripla (efavirenz / emtricitabine / tenofovir). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
    • Should be taken on an empty stomach at bedtime to reduce side effects.
    • Women taking Atripla (efavirenz / emtricitabine / tenofovir) should be on effective form(s) of contraception, as Atripla (efavirenz / emtricitabine / tenofovir) can cause birth defects.
    • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
    Coming soon
    • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
    • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
    • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
    • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
    • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
    • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
    • Emtriva (emtricitabine) should be taken at the same time everyday, with or without food.
    • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take extra medicine or double up if you've missed a previous dose.
    • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
    • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your prescriber.
    • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
    • People with HIV should be tested for Hepatitis B virus (HBV) before starting tenofovir.
    • Similarly, patients with chronic hepatitis B, should be tested for HIV before starting tenofovir.
    • Decreases in bone mineral density can happen while taking tenofovir.
    • Work with your doctor to monitor your kidney function and bone mineral density regularly.
    • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Sustiva (efavirenz). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
    • Should be taken on an empty stomach at bedtime to reduce side effects.
    • Women taking Sustiva (efavirenz) should be on effective form(s) of birth control, as Sustiva (efavirenz) can cause birth defects.
    • If swallowing the capsule is difficult, you may open the capsules and sprinkle/mix the contents over a small amount of food (eg. applesause, yogurt) before taking.
    • Talk to your doctor or pharmacist before starting any new medication while on Sustiva (efavirenz) to prevent drug interactions.
    • Keep your regularly scheduled doctor and lab appointments. These help ensure your medication is working well and safely.
    Learn more
    More about AtriplaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Atripla (efavirenz / emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about StribildSide effectsReviews & ratingsFDA package insert
    Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about CompleraSide effectsReviews & ratingsFDA package insert
    Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
    Worth itNot sureNot worth it
    More about TruvadaSide effectsReviews & ratingsFDA package insert
    Have you used Truvada (emtricitabine / tenofovir)?
    Worth itNot sureNot worth it
    More about EmtrivaSide effectsFDA package insert
    Have you used Emtriva (emtricitabine)?
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    More about VireadSide effectsFDA package insert
    Have you used Viread (tenofovir)?
    Worth itNot sureNot worth it
    More about SustivaSide effectsFDA package insert
    Have you used Sustiva (efavirenz)?
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