Prescription onlyLower-cost generic availableClass: Infection

Augmentin Alternatives

(amoxicillin / clavulanate)

Prescription onlyLower-cost generic availableClass: Infection
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Compare Augmentin (amoxicillin / clavulanate) to alternatives

These medications are comparable to Augmentin (amoxicillin / clavulanate) or used for similar purposes.

Augmentin
(amoxicillin / clavulanate)

Biaxin
(clarithromycin)

Cipro
(ciprofloxacin)

Keflex
(cephalexin)

Cleocin T
(clindamycin phosphate)

Levaquin
(levofloxacin)

Penicillin Vk
(penicillin)

Bactrim
(sulfamethoxazole / trimethoprim)

Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.Coming soon.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Treats bacterial infections. Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.Kills bacteria. Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
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Coupons for Augmentin
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Augmentin
Reviews for Augmentin
68%
of people (All ages) say Augmentin is worth it
52%
say it works well
13%
say it's a big hassle
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Biaxin (clarithromycin)?
Worth itNot sureNot worth it
Reviews for Cipro
63%
+5% better vs. Augmentin
53%
-1% worse vs. Augmentin
17%
+4% better vs. Augmentin
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Reviews for Keflex
64%
+4% better vs. Augmentin
48%
+4% better vs. Augmentin
14%
+1% better vs. Augmentin
686 reviews
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
Reviews for Cleocin
57%
+11% better vs. Augmentin
43%
+9% better vs. Augmentin
19%
+6% better vs. Augmentin
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Reviews for Levaquin
53%
+15% better vs. Augmentin
40%
+12% better vs. Augmentin
31%
+18% better vs. Augmentin
Have you used Levaquin (levofloxacin)?
Worth itNot sureNot worth it
Reviews for Penicillin
71%
-3% worse vs. Augmentin
52%
Same vs. Augmentin
12%
-1% worse vs. Augmentin
1297 reviews
Have you used Penicillin Vk (penicillin)?
Worth itNot sureNot worth it
Reviews for Bactrim
59%
+9% better vs. Augmentin
49%
+3% better vs. Augmentin
22%
+9% better vs. Augmentin
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »

We haven’t found good data for Biaxin side effects.

FDA side effect reports for Biaxin »
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »
  • Nausea 7%
  • Headache 6%
  • Diarrhea 5%
  • Sleep difficulty 4%
  • Dizziness 3%
  • Consitpation 3%
  • Abdominal pain 2%
  • Vomiting 2%
  • Indigestion 2%
  • Rash 2%
More Levaquin side effects »

The Penicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Penicillin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.Coming soon.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Keflex (cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Penicillin Vk (Penicillin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Infusion (iv)
  • Pill
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Pill
  • Liquid
  • Pill
  • Pill
  • Liquid
Used for
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
  • Acute Infective Exacerbation Of Chronic Bronchitis Acute Otitis Media Community Acquired Pneumonia Disseminated Infection Due To Mycobacterium Avium Intracellulare Group Disseminated Infection Due To Mycobacterium Avium Intracellulare Group Prophylaxis HIV Infection Duodenal Ulcer Disease Helicobacter Pylori Gastrointestinal Tract Infection Infection Of Skin AND OR Subcutaneous Tissue
Risk factors for serious side effects
AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
    Coming soon.
    • Over 60 years of age
    • On long-term steroid use
    • Heart, kidney, or lung transplant
    • Myasthenia gravis
    Detailed Cipro (ciprofloxacin) risks & warnings »
    • Weakened immune system
    • Not taking Keflex (cephalexin) correctly
    • History of penicillin or cephalosporin allergies
    Detailed Keflex (cephalexin) risks & warnings »
    • History of liver disease
    Detailed Cleocin T (clindamycin phosphate) risks & warnings »
    • Over 60 years of age
    • On long-term steroid use
    • Heart, kidney, or lung transplant
    • History of liver disease
    • Seizures
    Detailed Levaquin (levofloxacin) risks & warnings »
    • Prior severe allergic reaction to Penicillin Vk (Penicillin)
    Detailed Penicillin Vk (penicillin) risks & warnings »
    • Elderly
    • Taking other medicines that lower kidney function
    Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    • Take with food if you're having upset stomach.
    No food related info.No food related info.
    • Can take with or without food.
    • Can be taken with or without food.
    • Can be taken with or without food.
    No food related info.No food related info.No food related info.
    Kidneys and liver
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
    No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
    • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
    • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
    No kidneys and liver related info.
    • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
    Pain
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    No pain related info.No pain related info.
    • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
    • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
    • If you notice pain in your Achilles tendons, contact your doctor.
    No pain related info.
    • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
    • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
    • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage. It can happen as soon as you start taking the medication and may not go away if you stop it.
    • If you notice pain in your Achilles tendons, contact your doctor.
    No pain related info.No pain related info.
    Upsides and benefits
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    • Available as generic product.
    • Available in tablet, capsule, and liquid forms.
    • Used to treat most common types of bacterial infections.
    • Side effects are generally not too bad compared to other antibiotics.
    Coming soon
    • Available in generic.
    • Available in different forms: tablet, capsule, and suspension.
    • Used to treat many types of bacterial infections.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Available in generic.
    • Available in different forms: tablet, capsule, and suspension.
    • Used to treat many types of bacterial infections.
    • Can be taken with or without food.
    • Generally few side effects compared with other antibiotics.
    • Available in generic.
    • Topical form treats acne.
    • Available in different oral forms: tablet, capsule, and suspension.
    • Available in forms to treat skin infections and vaginal infections.
    • Used to treat many types of bacterial infections.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Can be taken with or without food.
    • Available in generic.
    • Available in different forms: tablet, capsule, and suspension.
    • Used to treat many types of bacterial infections.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Available in generic.
    • Available in different forms: tablet, capsule and suspension.
    • Used to treat many types of bacterial infections.
    • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
    • Works well to treat many types of bacterial infections
    Downsides and risks
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    • Many bacteria have developed resistance to this antibiotic.
    • Can cause diarrhea, nausea, and vomiting.
    • Birth control pills may not work as well to prevent pregnancy when taking this medication.
    Coming soon
    • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
    • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
    • Ciprofloxacin can make your skin more sensitive to the sun.
    • Can't be used if you've ever had myasthenia gravis.
    • Can cause diarrhea.
    • Can cause diarrhea.
    • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
    • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
    • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
    • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
    • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
    • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
    • If you're taking the topical form, it can cause sensitivity and irritation.
    • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
    • Levofloxacin can make your skin more sensitive to the sun.
    • Can't be used if you've ever had myasthenia gravis.
    • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
    • Can cause changes in taste, headaches, and insomnia.
    • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
    • Can make birth control pills less effective.
    • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
    • Makes you sensitive to the sun.
    • Can upset your stomach
    • Drink plenty of water or fluids to avoid harming your kidneys
    • May cause birth defects
    Tips from our pharmacists for people taking the medication
    AugmentinBiaxinCiproKeflexCleocinLevaquinPenicillinBactrim
    • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
    • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
    • Take with food if you're having upset stomach.
    • Store the liquid in the fridge and throw away after 10 days.
    • Shake the suspension thoroughly before using each dose.
    Coming soon
    • If you notice pain in your Achilles tendons, contact your doctor.
    • Wear sunscreen if you're going to be out in the sun.
    • Take the medication exactly how the doctor tells you to.
    • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
    • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
    • Can cause diarrhea, nausea or vomiting.
    • Limit your caffeine intake while taking this medication.
    • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance.
    • Store the suspension in the refrigerator. Shake well before using, and discard the bottle after 14 days.
    • Can take with or without food.
    • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
    • Take this medication exactly how your doctor tells you to.
    • Store the suspension at room temperature.
    • If you're using the topical form, it can take a few weeks to see the full effect.
    • Keep the topical form out of your eyes, nose and mouth.
    • If you're using the topical form, Don't put makeup or bandages over it.
    • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
    • If you notice pain in your Achilles tendons, contact your doctor.
    • Wear sunscreen if you're going to be out in the sun.
    • Take the medication exactly how the doctor tells you to.
    • Take this medication with plenty of fluids.
    • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
    • Can cause diarrhea, nausea or vomiting.
    • Can cause changes in taste, headaches and insomnia.
    • Take this medication exactly how your doctor tells you to.
    • If you're taking birth control pills, this medication can make them less effective.
    • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
    • Can cause diarrhea, nausea or vomiting.
    • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
    • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
    • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
    • Can cause upset stomach.
    • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
    Learn more
    More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Augmentin (amoxicillin / clavulanate)?
    Worth itNot sureNot worth it
    More about BiaxinSide effectsReviews & ratingsFDA package insert
    Have you used Biaxin (clarithromycin)?
    Worth itNot sureNot worth it
    More about CiproSide effectsReviews & ratingsFDA package insert
    Have you used Cipro (ciprofloxacin)?
    Worth itNot sureNot worth it
    More about KeflexSide effectsReviews & ratingsFDA package insert
    Have you used Keflex (cephalexin)?
    Worth itNot sureNot worth it
    More about CleocinSide effectsReviews & ratingsFDA package insert
    Have you used Cleocin T (clindamycin phosphate)?
    Worth itNot sureNot worth it
    More about LevaquinSide effectsReviews & ratingsFDA package insert
    Have you used Levaquin (levofloxacin)?
    Worth itNot sureNot worth it
    More about PenicillinSide effectsReviews & ratingsFDA package insert
    Have you used Penicillin Vk (penicillin)?
    Worth itNot sureNot worth it
    More about BactrimSide effectsReviews & ratingsFDA package insert
    Have you used Bactrim (sulfamethoxazole / trimethoprim)?
    Worth itNot sureNot worth it