Avastin (bevacizumab) is an effective, first-line option when used together with other medicines for certain types of cancers, but it has to be given in a clinic or hospital and it has many severe side effects.
- In studies, taking Avastin (bevacizumab) extended lives in the treatment of different types of cancers compared to people not taking Avastin (bevacizumab).
- The first drug in its class to be approved by the FDA that was shown to slow tumor growth and extend lives.
- Treats certain types of brain, cervical, colorectal, lung, and kidney cancers.
- Avastin (bevacizumab) is first-choice treatment for lung cancer (NSCLC) and colorectal cancer (metastatic, taken with chemotherapy), and second-choice treatment for other cancers.
- Avastin (bevacizumab) is typically given every 2 to 3 weeks and can be given along with other chemotherapy during the same visit.
- If you have heart or kidney problems, Avastin (bevacizumab) may increase your risk of side effects.
- It may take longer for you to heal. Avastin (bevacizumab) shouldn't be used for 28 days before and after surgery.
- Avastin (bevacizumab) can cause blood clots and bleeding.
- Avastin (bevacizumab) in some cases can damage the ovaries. Talk to your doctor before starting Avastin (bevacizumab) if you're pregnant or planning for pregnancy.
- There's no generic available so it can be expensive.
- Angiomyolipoma of kidney - Tuberous sclerosis syndrome
- Not requiring immediate surgery Breast cancer
- Hormone receptor-positive
- HER2 negative
- In combination with exemestane after failure with letrozole or anastrozole Liver transplant rejection
- Combination therapy; Prophylaxis Neuroendocrine tumor
- Locally advanced
- Or metastatic disease Renal cell carcinoma
- Advanced disease
- After failure of treatment with sunitinib or sorafenib Renal transplant rejection
- Low to moderate risk
- Combination therapy; Prophylaxis Subependymal giant cell astrocytoma - Tuberous sclerosis syndrome
- Stomach or intestine damage
First 50 days after starting Avastin (bevacizumab)
- Increased risk of severe bleeding
Taking other blood-thinning drugs
- Increased risk of blood clot
History of blood clot in the artery
...and 2 more risk factors
- High blood pressure
History of high blood pressure