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Zithromax Alternatives

(Azithromycin)

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Compare Zithromax (Azithromycin) to alternatives

These medications are comparable to Zithromax (Azithromycin) or used for similar purposes.

Zithromax
(Azithromycin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Cipro
(Ciprofloxacin)

Levaquin
(Levofloxacin)

Keflex
(Cephalexin)

Cleocin T
(Clindamycin Phosphate)

Vibramycin
(Doxycycline)

Augmentin
(Amoxicillin / Clavulanate)

Penicillin Vk
(Penicillin)

Amoxil
(Amoxicillin)

Kills bacteria. Zithromax (Azithromycin) is good for treating many bacterial infections. It is also available as generic. Talk to your doctor if you've ever had liver disease, myasthenia gravis, or on medications to thin the blood, as the doctor may write an alternative.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.Kills bacteria. Keflex (Cephalexin) is good for treating many bacterial infections and is available as generic. However, if you are on medications to thin your blood, you can be more likely to bleed.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Kills bacteria. Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.
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Reviews & ratings
Button Group. All currently active
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5.443093922651934Azithromycin
Reviews for Zithromax (Azithromycin)
74%
of people say Zithromax (Azithromycin) is worth it
59%
say it works well
11%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
15% vs. Zithromax (Azithromycin)
50%
9% vs. Zithromax (Azithromycin)
22%
11% vs. Zithromax (Azithromycin)
Reviews for Cipro (Ciprofloxacin)
64%
10% vs. Zithromax (Azithromycin)
53%
6% vs. Zithromax (Azithromycin)
17%
6% vs. Zithromax (Azithromycin)
Reviews for Levaquin (Levofloxacin)
54%
20% vs. Zithromax (Azithromycin)
39%
20% vs. Zithromax (Azithromycin)
29%
18% vs. Zithromax (Azithromycin)
Reviews for Keflex (Cephalexin)
63%
11% vs. Zithromax (Azithromycin)
48%
11% vs. Zithromax (Azithromycin)
14%
3% vs. Zithromax (Azithromycin)
Reviews for Cleocin T (Clindamycin Phosphate)
57%
17% vs. Zithromax (Azithromycin)
43%
16% vs. Zithromax (Azithromycin)
20%
9% vs. Zithromax (Azithromycin)
Reviews for Vibramycin (Doxycycline)
50%
24% vs. Zithromax (Azithromycin)
34%
25% vs. Zithromax (Azithromycin)
23%
12% vs. Zithromax (Azithromycin)
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
6% vs. Zithromax (Azithromycin)
52%
7% vs. Zithromax (Azithromycin)
13%
2% vs. Zithromax (Azithromycin)
Reviews for Penicillin Vk (Penicillin)
71%
3% vs. Zithromax (Azithromycin)
52%
7% vs. Zithromax (Azithromycin)
12%
1% vs. Zithromax (Azithromycin)
Reviews for Amoxil (Amoxicillin)
62%
12% vs. Zithromax (Azithromycin)
45%
14% vs. Zithromax (Azithromycin)
14%
3% vs. Zithromax (Azithromycin)
Side effects
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin

The Azithromycin FDA package insert doesn’t have numbers about how common side effects are.

More about Azithromycin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »

The Cipro FDA package insert doesn’t have numbers about how common side effects are.

More about Cipro side effects »

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Penicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Penicillin side effects »

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »
How it works
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
Zithromax (Azithromycin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Keflex (Cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Penicillin Vk (Penicillin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.
Type of medication
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
Antibiotic
Macrolide
Prescription only
Antibiotic
Sulfonamide
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Antibiotic
Cephalosporin
Prescription only
Acne agent
Antibiotic
Prescription only
Antibiotic
Tetracycline
Prescription only
Antibiotic
Penicillin
Prescription only
Antibiotic
Penicillin
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
  • Pill
  • Liquid
  • Eye drops
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Infusion (IV)
  • Pill
  • Liquid
  • Pill
  • Powder for oral suspension
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
Risk factors for serious side effects
AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
      • History of liver disease
      • History of myasthenia gravis
      Detailed Zithromax (Azithromycin) risks & warnings »
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      Pregnancy category
      AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Can be taken with or without food.
      • Can take with or without food.
      No specific food-related info.No specific food-related info.No specific food-related info.
      • Can be taken with or without food.
      • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
      • Can be taken with or without food.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Take with plenty of food and liquids.
      • Should be taken with food since it can cause stomach upset.
      • Take each dose with a meal since it may cause an upset stomach.
      • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
      • Take with food to decrease upsetting your stomach (nausea, vomiting).
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
      • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
      • Can be taken with or without food.
      • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
      • Available in different forms: tablet, capsule and suspension.
      • Can be taken with or without food.
      • Topical form treats acne.
      • Available in different oral forms: tablet, capsule, and suspension.
      • Available in forms to treat skin infections and vaginal infections.
      • Can be taken with or without food.
      • Available in different forms: tablet, capsule and suspension.
      Downsides and risks
      AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
      • Must space out antacids by at least 2 hours.
      • Has to be used with caution in people who've had liver disease.
      • Can't be used in people who've had myasthenia gravis.
      • Must be used with caution in people who are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
      • Can cause abdominal pain, diarrhea, vomiting, and nausea.
      • Has to be taken with plenty of liquids.
      • May cause birth defects.
      • Makes your skin more sensitive to the sun.
      • Can cause diarrhea.
      • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
      • Ciprofloxacin can make your skin more sensitive to the sun.
      • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
      • Can't be used if you've ever had myasthenia gravis.
      • Can cause diarrhea.
      • Levofloxacin can make your skin more sensitive to the sun.
      • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
      • Can cause changes in taste, headaches, and insomnia.
      • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
      • Can't be used if you've ever had myasthenia gravis.
      • If you're on blood thinners (anticoagulants), talk to your doctor, it may make you more likely to bleed.
      • If you have to take any live vaccines, talk to your doctor. You may have to postpone it.
      • Can cause diarrhea.
      • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
      • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
      • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
      • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
      • If you're taking the topical form, it can cause sensitivity and irritation.
      • Can't be used in pregnant women and children under 8 years old.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Can make birth control less effective.
      • Makes your skin more sensitive to the sun.
      • Can cause diarrhea.
      • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
      • Should be taken with food since it can cause stomach upset.
      • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
      • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
      • Can make birth control pills less effective.
      • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
      • Suspension must be stored in the fridge.
      • Can make birth control pills and live vaccines less effective.
      • Many bacteria have developed resistance to this antibiotic.
      • Can cause diarrhea.
      Tips from our pharmacists for people taking the medication
      AzithromycinBactrimCiproLevaquinKeflexCleocinDoxycyclineAugmentinPenicillinAmoxicillin
      • Space out any antacids with magnesium or aluminum by at least 2 hours.
      • Can take with or without food.
      • Take the medication exactly how your doctor tells you to.
      • Can make your skin more sensitive to the sun.
      • Drink plenty of liquids when taking the medication.
      • Can cause rash.
      • Take this medication exactly how your doctor tells you to.
      • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
      • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
      • Limit your caffeine intake while taking this medication.
      • If you notice pain in your Achilles tendons, contact your doctor.
      • Wear sunscreen if you're going to be out in the sun.
      • Take the medication exactly how the doctor tells you to.
      • Take this medication with plenty of fluids.
      • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
      • Can cause changes in taste, headaches and insomnia.
      • If you notice pain in your Achilles tendons, contact your doctor.
      • Wear sunscreen if you're going to be out in the sun.
      • Take the medication exactly how the doctor tells you to.
      • Space out vitamins by a couple hours if you're taking this medication.
      • Take this medication exactly as your doctor tells you to.
      • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
      • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
      • Store the suspension at room temperature.
      • If you're using the topical form, it can take a few weeks to see the full effect.
      • Keep the topical form out of your eyes, nose and mouth.
      • If you're using the topical form, Don't put makeup or bandages over it.
      • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
      • Take this medication exactly how your doctor tells you to.
      • If you're using birth control pills, this medication can make them less effective.
      • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
      • Space out any vitamins by at least two hours.
      • Take with plenty of food and liquids.
      • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
      • Don't lie down for at least 30 minutes after taking this medication.
      • Take the medication exactly how your doctor tells you to.
      • Take each dose with a meal since it may cause an upset stomach.
      • If you are taking birth control pills, this can make it less effective.
      • Take this medication exactly as your doctor tells you to.
      • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
      • If you're taking birth control pills, this medication can make them less effective.
      • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
      • Take this medication exactly how your doctor tells you to.
      • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
      • If you're taking birth control pills, this medication may make them less effective.
      • Take with food to decrease upsetting your stomach (nausea, vomiting).
      • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
      • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
      • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
      Learn more
      More about AzithromycinSide effectsReviews & ratingsAlternativesFDA package insert
      More about BactrimSide effectsReviews & ratingsFDA package insert
      More about CiproSide effectsReviews & ratingsFDA package insert
      More about LevaquinSide effectsReviews & ratingsFDA package insert
      More about KeflexSide effectsReviews & ratingsFDA package insert
      More about CleocinSide effectsReviews & ratingsFDA package insert
      More about DoxycyclineSide effectsReviews & ratingsFDA package insert
      More about AugmentinSide effectsReviews & ratingsFDA package insert
      More about PenicillinSide effectsReviews & ratingsFDA package insert
      More about AmoxicillinSide effectsReviews & ratingsFDA package insert