Prescription onlyLower-cost generic availableClass: Musculoskeletal



Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Relaxes your muscles.

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Our bottom line

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

Price and discounts
Best available price for 90 (10mg) tablets of baclofen
What is GoodRx?


  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
People say this drug is:
33 reviews


  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
How it works

Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.

What to expect when you take Lioresal (baclofen) for Muscle spasticity

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Side effect rates for Lioresal (baclofen)

  • Drowsiness

Risks and Warnings for Lioresal (baclofen)

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    • Higher risk if:
    • Stopping Lioresal (baclofen) too quickly

    If you've been taking Lioresal (baclofen) for a while, stopping it suddenly can be dangerous. People have had seizures and hallucinations. Talk to your doctor about stopping it slowly so this doesn't happen to you.

Common concerns from people taking Lioresal (baclofen)

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  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
  • Good for muscle aches from withdrawal but no other improvements from opiate withdrawal. Worked really well for muscle cramps and pain though. Not help with insomnia. I'm writing this review at 2:00am because I can't sleep.
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Sleep issues? I thought I was just an insomniac. Turns out it is this med that causes it. Also, folks say it's hard to get off this med.