Prescription onlyLower-cost generic available



  • Pill
  • Dissolving tablet
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Relaxes your muscles.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.

  • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
  • Can be used long term.
  • Relieves pain associated with muscle spasms.
  • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
  • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.
  • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
  • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.

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Side effects for Lioresal (Baclofen)

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These are side effects of Lioresal (Baclofen) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Lioresal (Baclofen)

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Tips from our pharmacists
  • Can cause dizziness and fatigue.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken as needed or 'around-the-clock'. Ask your doctor about what'll work best for you.
  • If taking regularly, you need to work with your doctor to get off the medication slowly (also called tapering) to avoid withdrawal symptoms.

Risks and Warnings for Lioresal (Baclofen)

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    • Higher risk if:
    • Stopping Lioresal (Baclofen) too quickly

    If taking the drug consistently, avoid stopping the drug abruptly. Stopping it too fast can cause serious muscle problems, sometimes even leading to organ failure. Risk is higher in patients with spinal injuries at T-6 or higher.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Lioresal (Baclofen)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Tips from our pharmacists
  • Don't drink alcohol while using this.
  • Tips from our pharmacists
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Good for muscle aches from withdrawal but no other improvements from opiate withdrawal. Worked really well for muscle cramps and pain though. Not help with insomnia. I'm writing this review at 2:00am because I can't sleep.
    Age: 32
    Gender: Woman
    Taken for: Withdrawal symptoms
    Duration taken: A couple weeks
  • Sleep issues? I thought I was just an insomniac. Turns out it is this med that causes it. Also, folks say it's hard to get off this med.
    Age: 36
    Gender: Woman
    Taken for: Spasticity
  • It may change your personality especially if you have been diagnosed with multiple personality disorder and cause you to sleep walk
    Age: 36
    Gender: Woman
    Taken for: Spasticity