Prescription onlyLower-cost generic available



Prescription onlyLower-cost generic available
  • Pill
  • Dissolving tablet
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Relaxes your muscles.

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Our bottom line

Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.

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  • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
  • Can be used long term.
  • Relieves pain associated with muscle spasms.
  • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
  • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.


  • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
  • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.
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Side effect rates for Lioresal (Baclofen)

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These are side effects of Lioresal (Baclofen) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Lioresal (Baclofen)

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    • Higher risk if:
    • Stopping Lioresal (Baclofen) too quickly

    If taking the drug consistently, avoid stopping the drug abruptly. Stopping it too fast can cause serious muscle problems, sometimes even leading to organ failure. Risk is higher in patients with spinal injuries at T-6 or higher.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Lioresal (Baclofen)

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  • Don't drink alcohol while using this.
  • Relieves pain associated with muscle spasms.
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.