Prescription onlyLower-cost generic available

Lioresal Alternatives

(Baclofen)

  • Pill
  • Dissolving tablet
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Compare Lioresal (Baclofen) to alternatives

These medications are comparable to Lioresal (Baclofen) or used for similar purposes.

Lioresal
(Baclofen)

Catapres
(Clonidine)

Zanaflex
(Tizanidine)

Valium
(Diazepam)

Neurontin
(Gabapentin)

Relaxes your muscles. Lioresal (Baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
Button Group. All currently active
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5baclofen
Reviews for Lioresal (Baclofen)
65%
of people say Lioresal (Baclofen) is worth it
61%
say it works well
22%
say it's a big hassle
Reviews for Catapres (Clonidine)
42%
23% vs. Lioresal (Baclofen)
33%
28% vs. Lioresal (Baclofen)
34%
12% vs. Lioresal (Baclofen)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Valium (Diazepam)
69%
+4% vs. Lioresal (Baclofen)
52%
9% vs. Lioresal (Baclofen)
16%
+6% vs. Lioresal (Baclofen)
Reviews for Neurontin (Gabapentin)
57%
8% vs. Lioresal (Baclofen)
39%
22% vs. Lioresal (Baclofen)
19%
+3% vs. Lioresal (Baclofen)
Side effects
baclofenCatapresZanaflexValiumNeurontin

We haven’t found good data for baclofen side effects.

FDA side effect reports for baclofen »

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
How it works
baclofenCatapresZanaflexValiumNeurontin
Lioresal (Baclofen) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
baclofenCatapresZanaflexValiumNeurontin
Muscle relaxerPrescription only
Antihypertensive
Alpha agonist
Prescription only
Muscle relaxer
Centrally-acting alpha agonist
Prescription only
Anti-anxiety
Benzodiazepine
Prescription only
Anticonvulsant
GABA analog
Prescription only
Available as
baclofenCatapresZanaflexValiumNeurontin
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Patch
  • Pill
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Oral solution
Used for (click to learn more)
baclofenCatapresZanaflexValiumNeurontin
Risk factors for serious side effects
baclofenCatapresZanaflexValiumNeurontin
  • Stopping Lioresal (Baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
  • Using other medicines that can cause seizures
  • History of seizures
  • Alcoholism
  • Eating disorders
  • Brain infections
Detailed Lioresal (Baclofen) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
baclofenCatapresZanaflexValiumNeurontin
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • Don't drink alcohol while using this.
No specific alcohol-related info.
  • Don't drink alcohol while using this.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
Food
No specific food-related info.No specific food-related info.
  • Need to be consistent every day in taking this with or without food.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
No specific food-related info.
  • Take the extended-release tablet with food.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
baclofenCatapresZanaflexValiumNeurontin
  • Lioresal (Baclofen) is effective for treating muscle spasms, as well as being an effective muscle relaxant.
  • Can be used long term.
  • Relieves pain associated with muscle spasms.
  • A better option for seniors compared to other muscle relaxants since it has less side effects than the other meds.
  • Lioresal (Baclofen) is available as a generic and is a relatively inexpensive medication.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
  • Relieves muscle spasms well.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving muscle spasms caused by a variety of conditions.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides and risks
baclofenCatapresZanaflexValiumNeurontin
  • If taking regularly, you shouldn't stop taking Lioresal (Baclofen) abruptly. You'll need to get off of it slowly.
  • Be careful if taking other drugs that affect your ability to stay awake, since Lioresal (Baclofen) can make you much more tired.
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
  • Can't stop taking this abruptly if you use it regularly.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
Tips from our pharmacists for people taking the medication
baclofenCatapresZanaflexValiumNeurontin
  • Can cause dizziness and fatigue.
  • Can cause extreme drowsiness or dizziness if you're taking it with high blood pressure medications.
  • Can be taken as needed or 'around-the-clock'. Ask your doctor about what'll work best for you.
  • If taking regularly, you need to work with your doctor to get off the medication slowly (also called tapering) to avoid withdrawal symptoms.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Usually taken together with other medicines for better blood pressure control.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • The weekly patch form can have fewer side effects.
  • Don't stop taking this medicine suddenly.
  • Extended release tablet also used to treat ADHD.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 30 minutes when swallowed.
  • Helpful with muscle spasms.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
Learn more
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
More about CatapresSide effectsReviews & ratingsFDA package insert
More about ZanaflexSide effectsReviews & ratingsFDA package insert
More about ValiumSide effectsReviews & ratingsFDA package insert
More about NeurontinSide effectsReviews & ratingsFDA package insert