Prescription onlyLower-cost generic availableClass: Musculoskeletal

Benemid Alternatives

(probenecid)

Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Compare Benemid (probenecid) to alternatives

These medications are comparable to Benemid (probenecid) or used for similar purposes.

Benemid
(probenecid)

Colcrys
(colchicine)

Uloric
(febuxostat)

Zyloprim
(allopurinol)

Lowers uric acid levels and strengthens penicillin's effect. Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.Prevents gout attacks. Uloric (Febuxostat) is a once a day medication for chronic gout, but it takes a few weeks to kick in.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
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Reviews & ratings
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Reviews for Benemid (probenecid)
Not enough review data. Review it!
of people (All ages) say Benemid (probenecid) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Benemid (probenecid)?
Worth itNot sureNot worth it
Reviews for Colcrys (colchicine)
Not enough review data. Review it!
+83% better vs. Benemid (probenecid)
Not enough review data. Review it!
+83% better vs. Benemid (probenecid)
Not enough review data. Review it!
-17% worse vs. Benemid (probenecid)
Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it
Reviews for Uloric (febuxostat)
Not enough review data. Review it!
+50% better vs. Benemid (probenecid)
Not enough review data. Review it!
+67% better vs. Benemid (probenecid)
Not enough review data. Review it!
-17% worse vs. Benemid (probenecid)
Have you used Uloric (febuxostat)?
Worth itNot sureNot worth it
Reviews for Zyloprim (allopurinol)
71%
+71% better vs. Benemid (probenecid)
52%
+52% better vs. Benemid (probenecid)
5%
-5% worse vs. Benemid (probenecid)
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
BenemidColcrysUloricAllopurinol

The Benemid FDA package insert doesn’t have numbers about how common side effects are.

More about Benemid side effects »
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »
  • Liver function abnormalities 6%
  • Rash 1%
More Uloric side effects »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
BenemidColcrysUloricAllopurinol
Benemid (probenecid) stops the kidneys from saving uric acid, so more uric acid leaves the body when you urinate. It also helps antibiotics like penicillin last longer in the body since it stops penicillin from going into the urine.Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.Uloric (Febuxostat) is an antigout xanthine oxidase inhibitor. It decreases the build up of uric acid, the enzyme that causes gout.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
BenemidColcrysUloricAllopurinol
Prescription only
Prescription only
Prescription only
Prescription only
Available as
BenemidColcrysUloricAllopurinol
  • Pill
  • Pill
  • Pill
  • Pill
  • Injection
Used for
BenemidColcrysUloricAllopurinol
Risk factors for serious side effects
BenemidColcrysUloricAllopurinol
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Taking Benemid (probenecid) for the first few weeks
  • History of kidney problems
  • History of esophagus or stomach problems, including ulcers
Detailed Benemid (probenecid) risks & warnings »
  • Grapefruit
  • Grapefruit juice
  • Protease inhibitors
  • Antifungal antibiotics
  • Calcium channel blockers
Detailed Colcrys (colchicine) risks & warnings »
    Detailed Uloric (febuxostat) risks & warnings »
    • History of kidney stones
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
    Detailed Zyloprim (allopurinol) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    BenemidColcrysUloricAllopurinol
    No interactions related info.
    • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
    No interactions related info.No interactions related info.
    Alcohol
    BenemidColcrysUloricAllopurinol
    No alcohol related info.No alcohol related info.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    No alcohol related info.
    Food
    BenemidColcrysUloricAllopurinol
    • Take Benemid (probenecid) with food or antacids to minimize stomach side effects.
    • Benemid (probenecid) can irritate your stomach or esophagus, and worsen ulcers. However, this is rare. Take Benemid (probenecid) with food to help stop this from happening. If you get chest pain or stomach pain, or worsening heartburn while taking Benemid (probenecid), talk with your doctor.
    • Take Colcrys (colchicine) with or without food.
    • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    • Take with food or milk to prevent an upset stomach.
    Kidneys and liver
    BenemidColcrysUloricAllopurinol
    • Benemid (probenecid) can cause kidney stones. Make sure to drink at least eight 8-ounce glasses of water a day while taking Benemid (probenecid). Let your doctor know if you start having back pain, belly pain, or blood in your urine as these may be signs of a kidney stone.
    • Doses needs to be changed if you have kidney or liver problems.
    • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
    Sleep
    BenemidColcrysUloricAllopurinol
    No sleep related info.No sleep related info.No sleep related info.
    • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
    Upsides and benefits
    BenemidColcrysUloricAllopurinol
    • Benemid (probenecid) is available in generic.
    • It can raise levels of certain antibiotics in the body and make those antibiotics work better.
    • It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
    • Colcrys (colchicine) treats and stops sudden gout attacks.
    • It can be used to prevent gout when people are first starting on allopurinol.
    • Colcrys (colchicine) also treats Familial Mediterranean fever.
    • In one clinical trial, Uloric (Febuxostat) was shown to decrease uric acid to normal levels in over half of the people taking it. It worked better than Zyloprim (allopurinol).
    • You only need to take Uloric (Febuxostat) once a day.
    • Uloric (Febuxostat) can be used in people with mild to moderate kidney disease.
    • Zyloprim (allopurinol) works well to lower uric acid in the body.
    • It is available as a generic medication.
    Downsides and risks
    BenemidColcrysUloricAllopurinol
    • Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
    • It doesn't work well in people who are using aspirin, or have kidney problems.
    • You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
    • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
    • Taking Colcrys (colchicine) for too long can cause problems with your blood.
    • Doses needs to be changed if you have kidney or liver problems.
    • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
    • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
    • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
    • Can increase the amount of gout attacks in the first few weeks.
    • You need to drink a lot of fluids while taking this to prevent kidney stones from forming.
    • While taking Uloric (Febuxostat), you'll have to get your blood checked often.
    • Doesn't come in a generic version.
    • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
    • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
    • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
    Tips from our pharmacists for people taking the medication
    BenemidColcrysUloricAllopurinol
    • Take Benemid (probenecid) with food or antacids to minimize stomach side effects.
    • Benemid (probenecid) doesn't work as well in people with kidney problems or the elderly.
    • Don't take aspirin while taking Benemid (probenecid).
    • Drink plenty of water while on Benemid (probenecid).
    • Take Colcrys (colchicine) with or without food.
    • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
    • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
    • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
    • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
    • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
    • In the first few months of taking Uloric (Febuxostat), you can still have gout attacks. Don’t give up since it takes a while to fully work. Your doctor can give you another medication to help until it's working well.
    • Take Uloric (Febuxostat) at the same time everyday, with or without food.
    • To make sure Uloric (Febuxostat) is working, have your blood checked often.
    • To help prevent attacks, avoid beer, sugary drinks, and foods like red meat, seafood, turkey, asparagus, cauliflower, spinach, and mushrooms.
    • Drink plenty of water while taking Zyloprim (allopurinol).
    • Take with food or milk to prevent an upset stomach.
    • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
    • Your doctor can run blood tests to make sure the medication is working as it should.
    • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
    • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
    Learn more
    More about BenemidSide effectsAlternativesFDA package insert
    Have you used Benemid (probenecid)?
    Worth itNot sureNot worth it
    More about ColcrysSide effectsReviews & ratingsFDA package insert
    Have you used Colcrys (colchicine)?
    Worth itNot sureNot worth it
    More about UloricSide effectsReviews & ratingsFDA package insert
    Have you used Uloric (febuxostat)?
    Worth itNot sureNot worth it
    More about AllopurinolSide effectsReviews & ratingsFDA package insert
    Have you used Zyloprim (allopurinol)?
    Worth itNot sureNot worth it