Prescription onlyLower-cost generic available


(Benzoyl Peroxide / Erythromycin)

  • Cream, gel, or ointment
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Topical treatment for acne.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..

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  • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
  • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
  • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
  • Although Benzamycin can irritate the skin, a true skin allergy is rare.
  • Can be used in combination with acne pill medicine if your doctor thinks you need it.
  • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
  • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
  • Can cause bleaching of hair and clothing.
  • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.

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Side effects for Benzamycin (Benzoyl Peroxide / Erythromycin)

From clinical trials of Benzamycin / Acne 

  • DynessDyness3% for Benzamycin vs.0% for placebo
  • Urticarial reactionUrticarial reaction3% for Benzamycin vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Burning sensation
  • Inflammation of the face, eys, and nose
  • Irritation of the eyes
  • Irritation of the skin
  • Itching
  • Oiliness
  • Peeling
  • Redness
  • Skin discoloration
  • Tenderness of the skin

What to expect when you start Benzamycin (Benzoyl Peroxide / Erythromycin)

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Tips from our pharmacists
  • Combination medicine you apply to your skin to treat acne.
  • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
  • Store in the refrigerator, but don't freeze.
  • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
  • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
  • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
  • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.

Risks and Warnings for Benzamycin (Benzoyl Peroxide / Erythromycin)

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  • Benzamycin (Benzoyl Peroxide / Erythromycin) can bleach hair, fabrics and carpet. Be careful to avoid hairline when applying to face. Wash your hands after using to avoid staining or discoloring fabrics and clothing.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Benzamycin (Benzoyl Peroxide / Erythromycin)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
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  • Upsides and downsides from our pharmacists
  • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.