Prescription onlyLower-cost generic available

Benzamycin Alternatives

(Benzoyl Peroxide / Erythromycin)

  • Cream, gel, or ointment
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Compare Benzamycin (Benzoyl Peroxide / Erythromycin) to alternatives

These medications are comparable to Benzamycin (Benzoyl Peroxide / Erythromycin) or used for similar purposes.

Benzamycin
(Benzoyl Peroxide / Erythromycin)

Epiduo
(Adapalene / Benzoyl Peroxide)

Duac
(Clindamycin / Benzoyl Peroxide)

Akne-Mycin
(Erythromycin)

Vibramycin
(Doxycycline)

Benzac
(Benzoyl Peroxide)

Cleocin T
(Clindamycin Phosphate)

Duac
(Clindamycin / Benzoyl Peroxide)

Solodyn
(Minocycline)

Differen
(Adapalene)

Renova
(Tretinoin)

Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..Coming soon.Coming soon.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Topical treatment for acne and skin wounds. Benzac (Benzoyl Peroxide) is a very popular topical acne treatment you can get over-the-counter or by prescription that may be better for people who don't want to take pill medication. Just be careful because it can bleach your hair, clothing and other fabrics.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.Coming soon.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.Coming soon.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
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Reviews & ratings
Button Group. All currently active
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4.527397260273973Benzamycin
Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
54%
of people say Benzamycin (Benzoyl Peroxide / Erythromycin) is worth it
26%
say it works well
12%
say it's a big hassle

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Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Akne-Mycin (Erythromycin)
46%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
34%
+8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
20%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Reviews for Vibramycin (Doxycycline)
50%
4% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
34%
+8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
23%
11% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Reviews for Benzac (Benzoyl Peroxide)
60%
+6% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
29%
+3% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
9%
+3% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Reviews for Cleocin T (Clindamycin Phosphate)
57%
+3% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
43%
+17% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
20%
8% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)

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Reviews for Renova (Tretinoin)
40%
14% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
26%
Same vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
28%
16% vs. Benzamycin (Benzoyl Peroxide / Erythromycin)
Side effects
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »

We haven’t found good data for Duac side effects.

FDA side effect reports for Duac »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »

The Benzoyl peroxide FDA package insert doesn’t have numbers about how common side effects are.

More about Benzoyl peroxide side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »

We haven’t found good data for Duac side effects.

FDA side effect reports for Duac »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »
  • Severe local irritation 6%
More Renova side effects »
How it works
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.Coming soon.Coming soon.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Benzac (Benzoyl Peroxide) is a topical acne medicine. It seems to fight the bacteria responsible for producing acne in oil (sebaceous) glands, and dries out acne-affected areas. Also, it speeds up growth of damaged skin from serious breakdown, injury, or disease.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.Coming soon.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Coming soon.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
Acne agent
Antibiotic
Prescription only
Coming soon.
Coming soon.
Acne agent
Antibiotic
Prescription only
Antibiotic
Tetracycline
Prescription only
Acne agent
Antibiotic
Prescription or OTC
Acne agent
Antibiotic
Prescription only
Coming soon.
Antibiotic
Tetracycline
Prescription only
Coming soon.
Acne agent
Retinoid
Prescription only
Available as
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Topical solution
  • Pill
  • Delayed release capsule
  • Liquid
  • Cream, gel, or ointment
  • Lotion
  • Liquid
  • Topical solution
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
  • Cream, gel, or ointment
  • Pill
  • Extended release
  • Extended release capsule
  • Cream, gel, or ointment
  • Cream, gel, or ointment
Used for (click to learn more)
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
  • Acne vulgaris
  • Acne vulgaris
  • Acne vulgaris
  • Acne vulgaris
Risk factors for serious side effects
BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
      Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Take with plenty of food and liquids.
      No specific food-related info.
      • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
      • Can be taken with or without food.
      No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
      • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
      No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
      • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
      • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
      • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
      • Although Benzamycin can irritate the skin, a true skin allergy is rare.
      • Can be used in combination with acne pill medicine if your doctor thinks you need it.
      Coming soon.Coming soon.
      • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
      • Available in a gel formulation which may be better if your skin is very oily.
      • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
      • Available in different forms: tablet, capsule, and suspension.
      • Available in generic.
      • Used to treat many types of bacterial infections.
      • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
      • Benzoyl peroxide is used to reduce bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
      • Helps stop blemishes from forming when oil and skin cells become trapped in pores.
      • Although Benzoyl peroxide can irritate the skin, a true skin allergy is rare.
      • It's available in non-prescription strengths, easy to buy at any drugstore and pretty cheap compared to prescription pills to treat your acne.
      • Can be used in combination with acne pill medicine if your doctor thinks you need it.
      • Topical form treats acne.
      • Available in different oral forms: tablet, capsule, and suspension.
      • Available in forms to treat skin infections and vaginal infections.
      • Can be taken with or without food.
      • Available in generic.
      • Used to treat many types of bacterial infections.
      • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
      • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
      • Available as a generic, so it should be reasonably priced.
      • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
      • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
      Coming soon.
      • You only need to apply it once a day, usually in the evening.
      • Most people who reported having skin irritation said that it was mild.
      • Part of a complete program to help you take better care of your skin.
      Downsides and risks
      BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
      • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
      • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
      • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
      • Can cause bleaching of hair and clothing.
      Coming soon.Coming soon.
      • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
      • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
      • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
      • Can't be used in pregnant women and children under 8 years old.
      • Makes your skin more sensitive to the sun.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Can make birth control less effective.
      • Can cause diarrhea.
      • Higher strengths (concentrations) can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • Not the best choice if you're pregnant. Benzoyl peroxide is categorized as pregnancy Category C (weigh risks vs benefits) as compared to similar topical medicines that are in Category B (likely safe).
      • May not work as well when used by itself over long period of time.
      • You'll need to stay out of the sun or apply a sunscreen if you have to be outdoors.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas.
      • Can cause bleaching of hair and clothing.
      • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
      • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
      • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
      • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
      • If you're taking the topical form, it can cause sensitivity and irritation.
      Coming soon.
      • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
      • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
      Coming soon.
      • It may take up to 6 months to see the full benefit for facial wrinkles.
      • Not a good choice for women who want to become or are pregnant
      • Can change the color and texture of your skin if used long-term.
      • You need to be careful about avoiding any sunlight or artificial tanning while using it.
      • It doesn't work for deep wrinkles.
      Tips from our pharmacists for people taking the medication
      BenzamycinEpiduoDuacErygelDoxycyclineBenzoyl peroxideCleocinDuacMinocyclineDifferenRenova
      • Combination medicine you apply to your skin to treat acne.
      • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
      • Store in the refrigerator, but don't freeze.
      • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
      • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      Coming soon.Coming soon.
      • Very commonly used topical antibiotic to treat acne.
      • The only topical erythromycin in a gel formula.
      • Apply a thin film to clean and dry affected skin once or twice a day.
      • It may take 6-8 weeks before you see improvement in your acne.
      • Avoid getting into your eyes, nose or mouth.
      • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      • Take the medication exactly how your doctor tells you to.
      • If you're using birth control pills, this medication can make them less effective.
      • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
      • Can cause diarrhea, nausea or vomiting.
      • Space out any vitamins by at least two hours.
      • Take with plenty of food and liquids.
      • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
      • Don't lie down for at least 30 minutes after taking this medication.
      • Acne can take several weeks to show up in the skin so it's best to use for 2-3 months before you decide it doesn't work.
      • Studies showed it didn't matter what strength people used, they all took about the same time to work.
      • Higher strengths greater than 2.5% may not work any better but might cause more side effects.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
      • Take this medication exactly how your doctor tells you to.
      • Store the suspension at room temperature.
      • If you're using the topical form, it can take a few weeks to see the full effect.
      • Keep the topical form out of your eyes, nose and mouth.
      • If you're using the topical form, Don't put makeup or bandages over it.
      • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
      Coming soon.
      • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
      • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
      • Can stain your teeth, tongue and gums, but this is temporary.
      • Take this exactly how your doctor or pharmacist tells you until it's all gone.
      • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
      Coming soon.
      • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
      • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
      • Apply a very small amount (pea-size) on entire face once a day at bedtime.
      • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
      • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
      • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
      • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
      Learn more
      More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert
      More about EpiduoSide effectsReviews & ratingsFDA package insert
      More about DuacSide effectsFDA package insert
      More about ErygelSide effectsReviews & ratingsFDA package insert
      More about DoxycyclineSide effectsReviews & ratingsFDA package insert
      More about Benzoyl peroxideSide effectsReviews & ratingsFDA package insert
      More about CleocinSide effectsReviews & ratingsFDA package insert
      More about DuacSide effectsFDA package insert
      More about MinocyclineSide effectsReviews & ratingsFDA package insert
      More about DifferenSide effectsReviews & ratingsFDA package insert
      More about RenovaSide effectsReviews & ratingsFDA package insert