Prescription onlyLower-cost generic availableClass: Mental health

Buspar Alternatives

(buspirone)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Buspar (buspirone) to alternatives

These medications are comparable to Buspar (buspirone) or used for similar purposes.

Buspar
(buspirone)

Xanax
(alprazolam)

Valium
(diazepam)

Klonopin
(clonazepam)

Ativan
(lorazepam)

Vistaril
(hydroxyzine pamoate)

Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.Helps you relax. Xanax (Alprazolam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and longer-term for panic attacks. More likely to cause withdrawal symptoms compared to similar drugs.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Ativan (lorazepam) is an effective medicine for occasional or short-term anxiety. It's less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63Buspar
Reviews for Buspar
46%
of people (All ages) say Buspar is worth it
45%
say it works well
22%
say it's a big hassle
Have you used Buspar (buspirone)?
Worth itNot sureNot worth it
Reviews for Xanax
74%
-28% worse vs. Buspar
55%
-10% worse vs. Buspar
13%
-9% worse vs. Buspar
1287 reviews
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it
Reviews for Valium
70%
-24% worse vs. Buspar
53%
-8% worse vs. Buspar
15%
-7% worse vs. Buspar
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Reviews for Klonopin
70%
-24% worse vs. Buspar
52%
-7% worse vs. Buspar
14%
-8% worse vs. Buspar
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Reviews for Ativan
71%
-25% worse vs. Buspar
51%
-6% worse vs. Buspar
15%
-7% worse vs. Buspar
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Vistaril (hydroxyzine pamoate)?
Worth itNot sureNot worth it
Side effects
BusparXanaxValiumKlonopinAtivanVistaril
  • Dizziness 9%
  • Any side effect 10%
  • Drowsiness 1%
  • Nausea 3%
  • Headache 3%
  • Nervousness 4%
  • Central nervous system disturbances 3%
More Buspar side effects »
  • Drowsiness 34%
  • Fatigue and Tiredness 6%
  • Impaired Coordination 23%
  • Irritability 3%
  • Memory Impairment 11%
  • Increased Appetite 10%
More Xanax side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Drowsiness 50%
  • Ataxia 30%
  • Behavior problems 25%
  • Somnolence 16%
  • Upper Respiratory Tract Infection 6%
  • Fatigue 5%
  • Depression 6%
  • Dizziness 1%
  • Colpitis 3%
  • Sinusitis 1%
More Klonopin side effects »
  • Sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »

We haven’t found good data for Vistaril side effects.

FDA side effect reports for Vistaril »
How it works
BusparXanaxValiumKlonopinAtivanVistaril
Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.Xanax (Alprazolam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Ativan (lorazepam) is a fast-acting benzodiazepine. It affects areas of the brain that help calm you down. This reduces anxiety and can cause sleepiness.Coming soon.
Type of medication
BusparXanaxValiumKlonopinAtivanVistaril
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
BusparXanaxValiumKlonopinAtivanVistaril
  • Pill
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
  • Injection
  • Pill
  • Liquid
Used for
BusparXanaxValiumKlonopinAtivanVistaril
  • Anxiety Pruritus Sedation Adjunct
Risk factors for serious side effects
BusparXanaxValiumKlonopinAtivanVistaril
  • Taking with MAOIs
  • Taking with Zyvox or methylene blue
  • Taking with or converting from benzodiazepine medicines
  • Duration of treatment
Detailed Buspar (buspirone) risks & warnings »
  • History of drug abuse
  • Taking with alcohol or drugs
  • Taking more than 4 mg/day or longer than 12 weeks
  • Stopping Xanax (Alprazolam) suddenly
  • Severely depressed
Detailed Xanax (alprazolam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Valium (diazepam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Klonopin (clonazepam) risks & warnings »
  • Taking with opioids
  • Taking more than the prescribed dose
  • Taking Ativan (lorazepam) for longer than 4 weeks
  • History of drug abuse
  • Long-term use
Detailed Ativan (lorazepam) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    BusparXanaxValiumKlonopinAtivanVistaril
    No interactions related info.No interactions related info.No interactions related info.No interactions related info.
    • Less likely to have drug interactions compared to other drugs like it, so it might be a better option if you're taking multiple medications.
    No interactions related info.
    Alcohol
    BusparXanaxValiumKlonopinAtivanVistaril
    • Avoid alcohol when taking Buspar (Buspirone).
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment or for people who've had problems with drug or alcohol abuse.
    No alcohol related info.
    Food
    BusparXanaxValiumKlonopinAtivanVistaril
    • Be consistent in taking Buspar (Buspirone) with or without food.
    No food related info.No food related info.No food related info.No food related info.No food related info.
    Kidneys and liver
    BusparXanaxValiumKlonopinAtivanVistaril
    No kidneys and liver related info.
    • Processed by the liver, so might not be the best choice if you have liver problems.
    • Processed by the liver, so might not be the best choice if you have liver problems.
    No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
    Sleep
    BusparXanaxValiumKlonopinAtivanVistaril
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    • Can cause temporary dizziness and drowsiness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause temporary dizziness and drowsiness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause dizziness, drowsiness, and salivation.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause temporary dizziness and drowsiness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    No sleep related info.
    Upsides and benefits
    BusparXanaxValiumKlonopinAtivanVistaril
    • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
    • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
    • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
    • Effective at relieving short-term anxiety.
    • Effective longer-term for panic attacks.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Effective at relieving short-term anxiety and sleeplessness.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Effective at relieving muscle spasms caused by a variety of conditions.
    • Less severe withdrawal symptoms compared to other benzodiazepines.
    • Effective at relieving short-term anxiety and sleeplessness.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Can be used alone or with other medicines to treat seizures.
    • Less severe withdrawal symptoms compared to other benzodiazepines.
    • Effective at relieving short-term anxiety.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in.
    • Less likely to have drug interactions compared to other drugs like it, so it might be a better option if you're taking multiple medications.
    Coming soon
    Downsides and risks
    BusparXanaxValiumKlonopinAtivanVistaril
    • Buspar (Buspirone) can take as long as four weeks to become fully effective.
    • Not as effective for short-term anxiety conditions or panic disorders.
    • Most people find that it loses effectiveness over long periods of time.
    • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
    • Processed by the liver, so might not be the best choice if you have liver problems.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
    • Processed by the liver, so might not be the best choice if you have liver problems.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Most people find that it gets less effective over time.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Most people find that it gets less effective over time.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment or for people who've had problems with drug or alcohol abuse.
    • Compared to other similar medicines, Ativan (lorazepam) is more likely to cause withdrawal if you take it for a long time and then suddenly stop.
    • Most people find that Ativan (lorazepam) gets less effective over time.
    Coming soon
    Tips from our pharmacists for people taking the medication
    BusparXanaxValiumKlonopinAtivanVistaril
    • Take doses at about the same time each day.
    • It can take several weeks to get the full effect.
    • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
    • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
    • Be consistent in taking Buspar (Buspirone) with or without food.
    • Avoid alcohol when taking Buspar (Buspirone).
    • Good for short-term relief of anxiety symptoms.
    • Starts working in 45 minutes when swallowed.
    • Can cause temporary dizziness and drowsiness.
    • Addictive. Long-term use can cause dependence or abuse.
    • Not safe to use with alcohol.
    • Good for short-term relief of anxiety symptoms.
    • Starts working in 30 minutes when swallowed.
    • Helpful with muscle spasms.
    • Can cause temporary dizziness and drowsiness.
    • Addictive. Long-term use can cause dependence or abuse.
    • Not safe to use with alcohol.
    • For the first week, avoid activities that require you to be alert.
    • Can cause dizziness, drowsiness, and salivation.
    • Report any confusion or inability to control muscle movements to your doctor.
    • Not safe to use with alcohol.
    • Can cause temporary dizziness and drowsiness.
    • Take only as much as your doctor prescribes. Taking more than directed or taking this for a long time can cause you to become dependent on it.
    • Not safe to use with alcohol.
    • Use caution or avoid use in older adults.
    Coming soon
    Learn more
    More about BusparSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Buspar (buspirone)?
    Worth itNot sureNot worth it
    More about XanaxSide effectsReviews & ratingsFDA package insert
    Have you used Xanax (alprazolam)?
    Worth itNot sureNot worth it
    More about ValiumSide effectsReviews & ratingsFDA package insert
    Have you used Valium (diazepam)?
    Worth itNot sureNot worth it
    More about KlonopinSide effectsReviews & ratingsFDA package insert
    Have you used Klonopin (clonazepam)?
    Worth itNot sureNot worth it
    More about AtivanSide effectsReviews & ratingsFDA package insert
    Have you used Ativan (lorazepam)?
    Worth itNot sureNot worth it
    More about VistarilSide effectsReviews & ratingsFDA package insert
    Have you used Vistaril (hydroxyzine pamoate)?
    Worth itNot sureNot worth it