Prescription onlyLower-cost generic available

Catapres Alternatives

(Clonidine)

Prescription onlyLower-cost generic available
  • Pill
  • Extended release
  • Patch
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Compare Catapres (Clonidine) to alternatives

These medications are comparable to Catapres (Clonidine) or used for similar purposes.

Catapres
(Clonidine)

Zestril
(Lisinopril)

Cozaar
(Losartan)

Norvasc
(Amlodipine)

Toprol Xl
(Metoprolol Succinate)

Tenormin
(Atenolol)

Coreg
(Carvedilol)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.Lowers blood pressure and controls heart rate. Tenormin (Atenolol) is good for controlling chest pain and treating heart failure and heart attack with fewer side effects than other beta blockers. You have to take it on an empty stomach, and you can't miss doses.Lowers blood pressure and controls heart rate. Coreg (Carvedilol) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
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4.223684210526316Catapres
Reviews for Catapres (Clonidine)
42%
of people (All ages) say Catapres (Clonidine) is worth it
33%
say it works well
34%
say it's a big hassle
Have you used Catapres (Clonidine)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+19% vs. Catapres (Clonidine)
51%
+18% vs. Catapres (Clonidine)
13%
+21% vs. Catapres (Clonidine)
676 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Reviews for Cozaar (Losartan)
57%
+15% vs. Catapres (Clonidine)
47%
+14% vs. Catapres (Clonidine)
16%
+18% vs. Catapres (Clonidine)
524 reviews
Have you used Cozaar (Losartan)?
Worth itNot sureNot worth it
Reviews for Norvasc (Amlodipine)
59%
+17% vs. Catapres (Clonidine)
50%
+17% vs. Catapres (Clonidine)
14%
+20% vs. Catapres (Clonidine)
435 reviews
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
Reviews for Toprol Xl (Metoprolol Succinate)
60%
+18% vs. Catapres (Clonidine)
55%
+22% vs. Catapres (Clonidine)
13%
+21% vs. Catapres (Clonidine)
163 reviews
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
Reviews for Tenormin (Atenolol)
57%
+15% vs. Catapres (Clonidine)
48%
+15% vs. Catapres (Clonidine)
16%
+18% vs. Catapres (Clonidine)
446 reviews
Have you used Tenormin (Atenolol)?
Worth itNot sureNot worth it
Reviews for Coreg (Carvedilol)
54%
+12% vs. Catapres (Clonidine)
46%
+13% vs. Catapres (Clonidine)
18%
+16% vs. Catapres (Clonidine)
403 reviews
Have you used Coreg (Carvedilol)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
+5% vs. Catapres (Clonidine)
31%
2% vs. Catapres (Clonidine)
15%
+19% vs. Catapres (Clonidine)
137 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Low blood sugar 4%
  • Low blood pressure 4%
  • Muscle weakness/fatiguea/fatigue 4%
  • Hyperkalemia 4%
  • Chest pain 4%
  • Low red blood cells 3%
  • Muscular weakness 3%
  • Orthostatic hypotension 3%
More Losartan side effects »
  • Swelling due to excess fluid 10%
  • Fatigue 2%
  • Nausea 1%
  • Dizziness 1%
More Norvasc side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
  • Tiredness 13%
  • Dizziness 7%
  • Cold extremities 7%
  • Low mood disorder 3%
  • Vivid dreams 2%
  • Shortness of breath 2%
  • Leg pain 2%
  • Nausea 2%
  • Diarrhea 1%
  • Fatigue 1%
More Atenolol side effects »
  • Dizziness 13%
  • Abnormally slow heartbeat 7%
  • Low blood pressure 6%
  • Diarrhea 6%
  • High blood sugar 4%
  • Nausea 4%
  • Vision abnormal 3%
  • Fainting 3%
  • Muscle weakness 2%
  • Edema dependent 2%
More Coreg side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Tenormin (Atenolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it less work to pump.Coreg (Carvedilol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
Antihypertensive
Alpha agonist
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
Angiotensin receptor blocker
Prescription only
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
  • Pill
  • Extended release
  • Patch
  • Pill
  • Pill
  • Pill
  • Pill
  • Extended release
  • Pill
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
Risk factors for serious side effects
CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Catapres (Clonidine) risks & warnings »
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Women of childbearing age
    • Concurrent liver disease
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Cozaar (Losartan) risks & warnings »
    • Age 65 years or older
    • History of heart problems
    • Liver disease
    • History of blood vessel disease
    • History of heart failure
    • History of kidney disease
    • Obesity
    Detailed Norvasc (Amlodipine) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      • History of asthma
      Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
      • Suddenly stopping Tenormin (Atenolol)
        • Taking calcium channel blockers
        • Major surgery requiring anesthesia
        • Diabetes
          • Taking clonidine
          Detailed Tenormin (Atenolol) risks & warnings »
          • Abrupt discontinuation of Coreg (Carvedilol)
              • Congestive heart failure
              • Increasing the dose of Coreg (Carvedilol)
              • Diabetes
              • Major surgery requiring anesthesia
                Detailed Coreg (Carvedilol) risks & warnings »
                • Current electrolyte imbalance
                • History of sulfa allergies
                • History of gout
                • Current kidney problems
                  Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
                  Pregnancy

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                  Interactions
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  No interactions related info.No interactions related info.No interactions related info.
                  • Interacts with the cholesterol medicine Simvastatin.
                  No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                  Food
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  No food related info.No food related info.No food related info.No food related info.No food related info.No food related info.
                  • You have to take Carvedilol with food.
                  • Take it with food.
                  No food related info.
                  Kidneys and liver
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  No kidneys and liver related info.
                  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
                  • Requires routine blood tests to check kidney function.
                  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
                  • Requires routine blood tests to check kidney function.
                  • Might not be a good choice if you have liver disease.
                  • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
                  No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
                  • Requires routine blood tests to check kidney function.
                  Pain
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  No pain related info.No pain related info.No pain related info.
                  • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
                  No pain related info.No pain related info.No pain related info.No pain related info.
                  Sleep
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  • Can cause drowsiness, headache, dizziness, and dry mouth.
                  No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
                  Upsides and benefits
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
                  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
                  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
                  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
                  • A first-choice blood pressure treatment for many people.
                  • Lowers the risk of heart attack and stroke.
                  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
                  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
                  • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
                  • A first-choice blood pressure treatment for many people.
                  • Lowers the risk of heart attack and stroke.
                  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
                  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
                  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
                  • Prevents heart-related chest pain (angina) if you take it regularly.
                  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
                  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
                  • A first-choice blood pressure treatment for many people.
                  • Lowers the risk of heart attack and stroke.
                  • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
                  • A first-choice treatment for heart failure. May prevent long-term heart damage.
                  • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
                  • Toprol XL is the extended release version of Lopressor.
                  • At lower doses, Atenolol has fewer side effects than most beta blockers because it targets the heart and doesn't cross into the brain and central nervous system.
                  • A first-choice treatment to prevent chest pain (angina).
                  • A first-choice treatment for heart failure and heart attack.
                  • For people with severe heart failure, Carvedilol lowers the risk of worsening heart failure, hospitalization, and sudden death.
                  • A first-choice treatment to prevent chest pain (angina).
                  • A first-choice treatment for heart failure and heart attack.
                  • Works well to get rid of extra fluids in your body through urination.
                  • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
                  • Good option if you have both high blood pressure and heart failure.
                  • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
                  • Most people have very few side effects.
                  • Lowers the risk of heart attack and stroke.
                  Downsides and risks
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
                  • The pill form can make some people sleepy, dizzy, and have dry mouth.
                  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
                  • Requires a yearly blood test to see how the medicine is affecting your body.
                  • Not safe to use if you're pregnant.
                  • Requires a yearly blood test to see how the medicine is affecting your body.
                  • Not safe to use if you're pregnant.
                  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
                  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
                  • Some people might experience flushing with this medication.
                  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
                  • Might not be a good choice if you have liver disease.
                  • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
                  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
                  • Can hide symptoms of low blood sugar if you're diabetic.
                  • You have to take Atenolol on an empty stomach.
                  • You can't miss doses. Stopping Atenolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
                  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
                  • Can hide symptoms of low blood sugar if you're diabetic.
                  • You have to take Carvedilol with food.
                  • You can't miss doses. Stopping Carvedilol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
                  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
                  • Can hide symptoms of low blood sugar if you're diabetic.
                  • Makes you urinate more often.
                  • Doesn't work well in people with severe kidney problems.
                  Tips from our pharmacists for people taking the medication
                  CatapresLisinoprilLosartanNorvascToprol XLAtenololCoregHydrochlorothiazide
                  • Usually taken together with other medicines for better blood pressure control.
                  • Can cause drowsiness, headache, dizziness, and dry mouth.
                  • If side effects don't go away, talk to your doctor about alternatives.
                  • The weekly patch form can have fewer side effects.
                  • Extended release tablet also used to treat ADHD.
                  • Don't stop taking this medicine suddenly.
                  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
                  • Requires routine blood tests to check kidney function.
                  • Don't take it if you're pregnant.
                  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
                  • Requires routine blood tests to check kidney function.
                  • Don't take it if you're pregnant.
                  • Interacts with the cholesterol medicine Simvastatin.
                  • Can cause ankle or foot swelling.
                  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
                  • Can cause fatigue and headache.
                  • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
                  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
                  • Don't stop taking this medicine suddenly.
                  • Take it on an empty stomach.
                  • Can cause fatigue and insomnia.
                  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
                  • Don't stop taking this medicine suddenly.
                  • Take it with food.
                  • Can cause fatigue and erectile dysfunction.
                  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
                  • Don't stop taking this medicine suddenly.
                  • Starts working in about 2 hours.
                  • Makes you urinate more often, so avoid taking it at bedtime.
                  • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
                  • Requires routine blood tests to check kidney function.
                  Learn more
                  More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
                  Have you used Catapres (Clonidine)?
                  Worth itNot sureNot worth it
                  More about LisinoprilSide effectsReviews & ratingsFDA package insert
                  Have you used Zestril (Lisinopril)?
                  Worth itNot sureNot worth it
                  More about LosartanSide effectsReviews & ratingsFDA package insert
                  Have you used Cozaar (Losartan)?
                  Worth itNot sureNot worth it
                  More about NorvascSide effectsReviews & ratingsFDA package insert
                  Have you used Norvasc (Amlodipine)?
                  Worth itNot sureNot worth it
                  More about Toprol XLSide effectsReviews & ratingsFDA package insert
                  Have you used Toprol Xl (Metoprolol Succinate)?
                  Worth itNot sureNot worth it
                  More about AtenololSide effectsReviews & ratingsFDA package insert
                  Have you used Tenormin (Atenolol)?
                  Worth itNot sureNot worth it
                  More about CoregSide effectsReviews & ratingsFDA package insert
                  Have you used Coreg (Carvedilol)?
                  Worth itNot sureNot worth it
                  More about HydrochlorothiazideSide effectsReviews & ratingsFDA package insert
                  Have you used Microzide (Hydrochlorothiazide (Hctz))?
                  Worth itNot sureNot worth it