Prescription onlyLower-cost generic availableClass: Infection

Ancef Alternatives

(cefazolin)

Prescription onlyLower-cost generic availableClass: Infection
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Compare Ancef (cefazolin) to alternatives

These medications are comparable to Ancef (cefazolin) or used for similar purposes.

Ancef
(cefazolin)

Keflex
(cephalexin)

Amoxil
(amoxicillin)

Penicillin Vk
(penicillin)

Zosyn
(piperacillin-tazobactam)

Treats bacterial infections. Ancef (cefazolin) is only available as an injectable, so it is usually only used in the hospital. It's good for treating many bacterial infections.Treats bacterial infections. Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Kills bacteria. Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.Treats bacterial infections. Zosyn (piperacillin-tazobactam) is only available as an injectable, so it's usually only given in the hospital. You can take Zosyn (piperacillin-tazobactam) at home, but it has to be stored in the fridge and used every 6 hours.
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Reviews & ratings
Filter group. All currently selected
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Reviews for Ancef (cefazolin)
Not enough review data. Review it!
of people (All ages) say Ancef (cefazolin) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Ancef (cefazolin)?
Worth itNot sureNot worth it
Reviews for Keflex (cephalexin)
64%
+64% better vs. Ancef (cefazolin)
48%
+48% better vs. Ancef (cefazolin)
14%
-14% worse vs. Ancef (cefazolin)
686 reviews
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
Reviews for Amoxil (amoxicillin)
62%
+62% better vs. Ancef (cefazolin)
45%
+45% better vs. Ancef (cefazolin)
14%
-14% worse vs. Ancef (cefazolin)
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Penicillin Vk (penicillin)
71%
+71% better vs. Ancef (cefazolin)
52%
+52% better vs. Ancef (cefazolin)
12%
-12% worse vs. Ancef (cefazolin)
1297 reviews
Have you used Penicillin Vk (penicillin)?
Worth itNot sureNot worth it
Reviews for Zosyn (piperacillin-tazobactam)
Not enough review data. Review it!
Same vs. Ancef (cefazolin)
Not enough review data. Review it!
Same vs. Ancef (cefazolin)
Not enough review data. Review it!
Same vs. Ancef (cefazolin)
Have you used Zosyn (piperacillin-tazobactam)?
Worth itNot sureNot worth it
Side effects
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam

The cefazolin FDA package insert doesn’t have numbers about how common side effects are.

More about cefazolin side effects »

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »

The Penicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Penicillin side effects »
  • Diarrhea 11%
  • Constipation 8%
  • Headache 8%
  • Nausea 7%
  • Trouble sleeping 7%
  • Rash 4%
  • Vomiting 3%
  • Heartburn 3%
  • Itchy skin 3%
  • Fungal infection 2%
More piperacillin-tazobactam side effects »
How it works
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
Ancef (cefazolin) is an antibacterial. It kills bacteria by preventing them from making their own protective covering.Keflex (cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Penicillin Vk (Penicillin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Zosyn (piperacillin-tazobactam) is a combination of two medicines: piperacillin and tazobactam. Piperacillin is an antibiotic that kills bacteria by preventing them from making their own protective covering. Tazobactam helps piperacillin work against more infections by stopping breakdown of the antibiotic by bacteria.
Type of medication
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
  • Injection
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Injection
Used for
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
Risk factors for serious side effects
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
  • Allergy to antibiotics
  • Kidney problems
  • Taking blood thinners
Detailed Ancef (cefazolin) risks & warnings »
  • Weakened immune system
  • Not taking Keflex (cephalexin) correctly
  • History of penicillin or cephalosporin allergies
Detailed Keflex (cephalexin) risks & warnings »
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • Prior severe allergic reaction to Penicillin Vk (Penicillin)
Detailed Penicillin Vk (penicillin) risks & warnings »
  • Allergy to antibiotics
  • Kidney problems
  • Taking blood thinners
  • Taking medicines that affect potassium (blood pressure medicines)
Detailed Zosyn (piperacillin-tazobactam) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
No food related info.
  • Can be taken with or without food.
  • Can take with or without food.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
No food related info.No food related info.
Kidneys and liver
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • If you have kidney problems or are on a low or no sodium diet, you might not be able to use this medication.
  • Zosyn (piperacillin-tazobactam) can cause an imbalance of sodium and potassium in the body because it contains sodium. If you're on a low or no-sodium diet because of your kidneys, or if you're taking medicines that affect your potassium (blood pressure medications like Lasix or a water pill), your doctor might have to change them. Your doctor might do blood tests to check your body's sodium and potassium. Make sure to talk to your doctor about your diet and medicines before starting Zosyn (piperacillin-tazobactam).
Upsides and benefits
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
  • Ancef (cefazolin) is available as a generic.
  • It is good at treating many types of bacterial infections.
  • People usually have few side effects when taking it.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule and suspension.
  • Used to treat many types of bacterial infections.
  • Zosyn (piperacillin-tazobactam) is available as a generic.
  • It is good at treating many types of serious bacterial infections.
  • Bacteria are less resistant to it than to other antibiotics.
  • Most people who take Zosyn (piperacillin-tazobactam) have few side effects.
Downsides and risks
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
  • Ancef (cefazolin) is only available as an injectable, and is usually only given in the hospital.
  • If you're taking it at home, a nurse might have to do the injections for you and also do blood tests.
  • If you're taking warfarin, you might have to change your dose while you're taking Ancef (cefazolin).
  • Like all antibacterials, it can cause diarrhea.
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
  • Can make birth control pills less effective.
  • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
  • Zosyn (piperacillin-tazobactam) is only available as an injectable.
  • You can use Zosyn (piperacillin-tazobactam) at home, but you have to have a small tube placed into your skin and have the medicine injected every 6 hours, which can be hard to remember.
  • Zosyn (piperacillin-tazobactam) can cause very bad side effects such as a serious blistering rash all over your body.
  • If you have kidney problems or are on a low or no sodium diet, you might not be able to use this medication.
Tips from our pharmacists for people taking the medication
cefazolinKeflexamoxicillinPenicillinpiperacillin-tazobactam
  • If you have to take Ancef (cefazolin) at home, your doctor will place a small tube into your skin. You or a nurse will inject the medicine directly into this tube. Store Ancef (cefazolin) in the fridge. To make the injection more comfortable, take the medicine out of the fridge 30 minutes before you use it and let it sit at room temperature.
  • Before taking Ancef (cefazolin), tell your doctor if you are allergic to cephalosporins, penicillins, or any other medications.
  • Tell your doctor or get medical help right away if you get a rash, itchy skin, trouble breathing, or swelling in your face or mouth.
  • Diarrhea is a common side effect that should go away when you stop the medicine; tell your doctor if it doesn't stop.
  • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance.
  • Store the suspension in the refrigerator. Shake well before using, and discard the bottle after 14 days.
  • Can take with or without food.
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • Take this medication exactly how your doctor tells you to.
  • If you're taking birth control pills, this medication can make them less effective.
  • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
  • Can cause diarrhea, nausea or vomiting.
  • Zosyn (piperacillin-tazobactam) is usually only given as an injection in the hospital. If you need to take it at home, your doctor will place a small tube in your skin through which you can inject the medicine. Store Zosyn (piperacillin-tazobactam) in the fridge, but take it out at least 30 minutes before you inject it, so it can warm to room temperature.
  • Before taking Zosyn (piperacillin-tazobactam), tell your doctor if you are allergic to penicillins or any other medications.
  • Tell your doctor or get medical help right away if you get a rash, itchy skin, trouble breathing, or swelling in your face or mouth.
  • Before using Zosyn (piperacillin-tazobactam), tell your doctor if you are on a low-sodium or sodium-free diet.
  • If you're on hormonal birth control such as the pill, it might not work as while you are taking Zosyn (piperacillin-tazobactam), so you should also use a barrier method such as condoms.
Learn more
More about cefazolinSide effectsAlternativesFDA package insert
Have you used Ancef (cefazolin)?
Worth itNot sureNot worth it
More about KeflexSide effectsReviews & ratingsFDA package insert
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
More about amoxicillinSide effectsReviews & ratingsFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about PenicillinSide effectsReviews & ratingsFDA package insert
Have you used Penicillin Vk (penicillin)?
Worth itNot sureNot worth it
More about piperacillin-tazobactamSide effectsFDA package insert
Have you used Zosyn (piperacillin-tazobactam)?
Worth itNot sureNot worth it