Prescription onlyLower-cost generic availableClass: Infection

Rocephin Alternatives

(ceftriaxone)

Prescription onlyLower-cost generic availableClass: Infection
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Compare Rocephin (ceftriaxone) to alternatives

These medications are comparable to Rocephin (ceftriaxone) or used for similar purposes.

Rocephin
(ceftriaxone)

Claforan
(cefotaxime)

Vantin
(cefpodoxime)

Cipro
(ciprofloxacin)

Bactrim
(sulfamethoxazole / trimethoprim)

Bactrim
(sulfamethoxazole / trimethoprim)

Treats bacterial infections. Rocephin (ceftriaxone) is good for treating many bacterial infections, but it is only available as an injectable, so it is usually only used in a hospital or doctor's office.Treats bacterial infections. Claforan (cefotaxime) is good for treating many bacterial infections, but it is only available as an injectable, so it is usually only used in the hospital.Coming soon.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Rocephin (ceftriaxone)
Not enough review data. Review it!
of people (All ages) say Rocephin (ceftriaxone) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Rocephin (ceftriaxone)?
Worth itNot sureNot worth it
Reviews for Claforan (cefotaxime)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Have you used Claforan (cefotaxime)?
Worth itNot sureNot worth it
Reviews for Vantin (cefpodoxime)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Not enough review data. Review it!
Same vs. Rocephin (ceftriaxone)
Have you used Vantin (cefpodoxime)?
Worth itNot sureNot worth it
Reviews for Cipro (ciprofloxacin)
63%
+63% better vs. Rocephin (ceftriaxone)
53%
+53% better vs. Rocephin (ceftriaxone)
17%
-17% worse vs. Rocephin (ceftriaxone)
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Reviews for Bactrim (sulfamethoxazole / trimethoprim)
59%
+59% better vs. Rocephin (ceftriaxone)
49%
+49% better vs. Rocephin (ceftriaxone)
22%
-22% worse vs. Rocephin (ceftriaxone)
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
ceftriaxonecefotaximeVantinCiproBactrimBactrim
  • High platelets 5%
  • Diarrhea 3%
  • Abnormal liver tests 3%
  • Rash 2%
More ceftriaxone side effects »
  • Soreness and pain at injection site 4%
  • Redness and swelling at injection site 4%
  • Rash 2%
  • Itchy skin 2%
  • Swelling 2%
  • Fever 2%
More cefotaxime side effects »

We haven’t found good data for Vantin side effects.

FDA side effect reports for Vantin »
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
ceftriaxonecefotaximeVantinCiproBactrimBactrim
Rocephin (ceftriaxone) is an antibacterial. It kills bacteria by preventing them from making their own protective covering.Claforan (cefotaxime) is an antibacterial. It kills bacteria by preventing them from making their own protective covering.Coming soon.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
ceftriaxonecefotaximeVantinCiproBactrimBactrim
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
ceftriaxonecefotaximeVantinCiproBactrimBactrim
  • Injection
  • Injection
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Infusion (iv)
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
ceftriaxonecefotaximeVantinCiproBactrimBactrim
  • Acute Otitis Media Bronchitis
Risk factors for serious side effects
ceftriaxonecefotaximeVantinCiproBactrimBactrim
  • Allergic to antibiotics (penicillins, cephalosporins)
  • History of gallbladder disease
  • Severe kidney problems
  • Child
  • Severe illness
Detailed Rocephin (ceftriaxone) risks & warnings »
  • Allergy to antibiotics
  • Taking Claforan (cefotaxime) for more than 10 days
  • Taking Claforan (cefotaxime) for a long time
Detailed Claforan (cefotaxime) risks & warnings »
    Coming soon.
    • Over 60 years of age
    • On long-term steroid use
    • Heart, kidney, or lung transplant
    • Myasthenia gravis
    Detailed Cipro (ciprofloxacin) risks & warnings »
    • Elderly
    • Taking other medicines that lower kidney function
    Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
    • Elderly
    • Taking other medicines that lower kidney function
    Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    ceftriaxonecefotaximeVantinCiproBactrimBactrim
    No kidneys and liver related info.
    • You might not be able to use Claforan (cefotaxime) if you've had problems with your large intestine or kidneys.
    No kidneys and liver related info.No kidneys and liver related info.
    • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
    • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
    Pain
    ceftriaxonecefotaximeVantinCiproBactrimBactrim
    No pain related info.
    • Claforan (cefotaxime) may cause tissue damage if the drug leaks from the vein. Tell your doctor or nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
    No pain related info.
    • If you notice pain in your Achilles tendons, contact your doctor.
    • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
    • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
    No pain related info.No pain related info.
    Upsides and benefits
    ceftriaxonecefotaximeVantinCiproBactrimBactrim
    • Rocephin (ceftriaxone) is available as a generic.
    • It is good at treating many types of bacterial infections.
    • People usually have few side effects when taking it.
    • Claforan (cefotaxime) is available as a generic.
    • It treats many types of bacterial infections.
    • People usually have few side effects when taking it.
    Coming soon
    • Available in generic.
    • Available in different forms: tablet, capsule, and suspension.
    • Used to treat many types of bacterial infections.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
    • Works well to treat many types of bacterial infections
    • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
    • Works well to treat many types of bacterial infections
    Downsides and risks
    ceftriaxonecefotaximeVantinCiproBactrimBactrim
    • Rocephin (ceftriaxone) is only available as an injectable.
    • If you have to take Rocephin (ceftriaxone) at home, your doctor will have to place a small tube into your skin, and either you or a nurse will inject the medicine.
    • If you're taking Rocephin (ceftriaxone) at home, you have to store it in the fridge, and a nurse might have to see you often to do blood tests.
    • You might not be able to use Rocephin (ceftriaxone) if you've had problems with your large intestine or gallbladder.
    • Claforan (cefotaxime) is only available as an injectable.
    • If you have to take it at home, your doctor will place a small tube into your skin, and either you or a nurse will inject the medicine.
    • If you're taking Claforan (cefotaxime) at home, you have to store it in the fridge, and a nurse might have to see you often to do blood tests.
    • You might not be able to use Claforan (cefotaxime) if you've had problems with your large intestine or kidneys.
    • Claforan (cefotaxime) may cause nausea, vomiting, or fever.
    Coming soon
    • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
    • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
    • Ciprofloxacin can make your skin more sensitive to the sun.
    • Can't be used if you've ever had myasthenia gravis.
    • Can cause diarrhea.
    • Makes you sensitive to the sun.
    • Can upset your stomach
    • Drink plenty of water or fluids to avoid harming your kidneys
    • May cause birth defects
    • Makes you sensitive to the sun.
    • Can upset your stomach
    • Drink plenty of water or fluids to avoid harming your kidneys
    • May cause birth defects
    Tips from our pharmacists for people taking the medication
    ceftriaxonecefotaximeVantinCiproBactrimBactrim
    • Rocephin (ceftriaxone) is usually given in a hospital or doctor’s office. If you have to take it at home, your doctor might place a small tube into your skin so the medicine can be injected. Store the medicine in the fridge, but take it out and leave it at room temperature for at least 30 minutes before you inject it.
    • Before taking Rocephin (ceftriaxone), tell your doctor if you are allergic to cephalosporins, penicillins, or any other medications.
    • Tell your doctor or get medical help right away if you get a rash, itchy skin, trouble breathing, or swelling in your face or mouth.
    • Diarrhea is a common side effect that should go away when you stop Rocephin (ceftriaxone). Tell your doctor if it doesn't stop, or if you develop very watery or bloody stools.
    • Claforan (cefotaxime) is usually given in the hospital. If you have to take it at home, your doctor will place a small tube into your skin to inject the medicine.
    • Store Claforan (cefotaxime) in the fridge, but take it out and leave it at room temperature for at least 30 minutes before you inject it.
    • Before taking Claforan (cefotaxime), tell your doctor if you are allergic to cephalosporins, penicillins, or any other medications.
    • Tell your doctor or get medical help right away if you get a rash, itchy skin, trouble breathing, or swelling in your face or mouth.
    • Diarrhea is a common side effect that should go away when you stop the medication. Tell your doctor if it doesn't stop, or if you develop very watery or bloody stools.
    Coming soon
    • If you notice pain in your Achilles tendons, contact your doctor.
    • Wear sunscreen if you're going to be out in the sun.
    • Take the medication exactly how the doctor tells you to.
    • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
    • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
    • Can cause diarrhea, nausea or vomiting.
    • Limit your caffeine intake while taking this medication.
    • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
    • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
    • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
    • Can cause upset stomach.
    • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
    • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
    • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
    • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
    • Can cause upset stomach.
    • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
    Learn more
    More about ceftriaxoneSide effectsAlternativesFDA package insert
    Have you used Rocephin (ceftriaxone)?
    Worth itNot sureNot worth it
    More about cefotaximeSide effectsFDA package insert
    Have you used Claforan (cefotaxime)?
    Worth itNot sureNot worth it
    More about VantinSide effectsFDA package insert
    Have you used Vantin (cefpodoxime)?
    Worth itNot sureNot worth it
    More about CiproSide effectsReviews & ratingsFDA package insert
    Have you used Cipro (ciprofloxacin)?
    Worth itNot sureNot worth it
    More about BactrimSide effectsReviews & ratingsFDA package insert
    Have you used Bactrim (sulfamethoxazole / trimethoprim)?
    Worth itNot sureNot worth it
    More about BactrimSide effectsReviews & ratingsFDA package insert
    Have you used Bactrim (sulfamethoxazole / trimethoprim)?
    Worth itNot sureNot worth it