Prescription onlyNo lower cost generic available


(Synthetic Conjugated Estrogens)

Prescription onlyNo lower cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
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Relieves hot flashes and vaginal dryness due to menopause.

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Our bottom line

Cenestin (Synthetic Conjugated Estrogens) relieves menopausal symptoms. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

Coupons and discounts
  • (30) 0.3mg tablet
  • Cost for (30) 0.3mg tablets of Cenestin (Synthetic Conjugated Estrogens) at pharmacies


  • Cenestin (Synthetic Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
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  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Cenestin (Synthetic Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
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Side effect rates for Cenestin (Synthetic Conjugated Estrogens)

103 From clinical trials of Cenestin / Postmenopausal estrogen replacement (0.45 mg)
  • Endometrial thickening
  • Ear, nose, or throat infection
  • Muscle weakness
  • Pain
  • Headache
  • Pain abdominal
  • Nausea
  • Joint pain
  • Tingling sensation
  • Vaginitis

Risks and Warnings for Cenestin (Synthetic Conjugated Estrogens)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Cenestin (Synthetic Conjugated Estrogens)

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  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Can cause nausea, dizziness, bloating and breast tenderness.