Prescription onlyLower-cost generic availableClass: Neuro/psych

Librium Alternatives

(chlordiazepoxide)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Compare Librium (chlordiazepoxide) to alternatives

These medications are comparable to Librium (chlordiazepoxide) or used for similar purposes.

Librium
(chlordiazepoxide)

Xanax
(alprazolam)

Valium
(diazepam)

Ativan
(lorazepam)

Halcion
(triazolam)

Restoril
(temazepam)

Serax
(oxazepam)

Reduces anxiety. Librium (chlordiazepoxide) is good for lowering anxiety since its effects aren't as strong as similar medicines; however, it lasts longer in the body and can be more dangerous in older people.Helps you relax. Xanax (Alprazolam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and longer-term for panic attacks. More likely to cause withdrawal symptoms compared to similar drugs.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Helps you stay asleep. Halcion (triazolam) can be used to help you fall asleep, but your body can become used to it very quickly.Helps you relax and sleep. Restoril (Temazepam) is a good short-term option to help you sleep, but it shouldn't replace good sleep habits.Controls anxiety symptoms and alcohol withdrawal. Serax (oxazepam) helps make sure the seizures that happen during alcohol withdrawal don't get worse. Serax (oxazepam) is also good for short-term relief of anxiety symptoms.
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Reviews & ratings
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Reviews for Librium (chlordiazepoxide)
Not enough review data. Review it!
of people (All ages) say Librium (chlordiazepoxide) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Librium (chlordiazepoxide)?
Worth itNot sureNot worth it
Reviews for Xanax (alprazolam)
74%
+74% better vs. Librium (chlordiazepoxide)
55%
+55% better vs. Librium (chlordiazepoxide)
13%
-13% worse vs. Librium (chlordiazepoxide)
1287 reviews
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it
Reviews for Valium (diazepam)
70%
+70% better vs. Librium (chlordiazepoxide)
53%
+53% better vs. Librium (chlordiazepoxide)
15%
-15% worse vs. Librium (chlordiazepoxide)
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Reviews for Ativan (lorazepam)
71%
+71% better vs. Librium (chlordiazepoxide)
51%
+51% better vs. Librium (chlordiazepoxide)
15%
-15% worse vs. Librium (chlordiazepoxide)
642 reviews
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
Reviews for Halcion (triazolam)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Have you used Halcion (triazolam)?
Worth itNot sureNot worth it
Reviews for Restoril (temazepam)
65%
+65% better vs. Librium (chlordiazepoxide)
55%
+55% better vs. Librium (chlordiazepoxide)
16%
-16% worse vs. Librium (chlordiazepoxide)
Have you used Restoril (temazepam)?
Worth itNot sureNot worth it
Reviews for Serax (oxazepam)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Not enough review data. Review it!
Same vs. Librium (chlordiazepoxide)
Have you used Serax (oxazepam)?
Worth itNot sureNot worth it
Side effects
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam

The chlordiazepoxide FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide side effects »
  • Drowsiness 34%
  • Fatigue and tiredness 6%
  • Impaired coordination 23%
  • Irritability 3%
  • Memory impairment 11%
  • Increased appetite 10%
More Xanax side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Relaxation or sleepiness 16%
  • Dizziness 7%
  • Weakness 4%
  • Unsteadiness 3%
More Ativan side effects »
  • Drowsiness 8%
  • Headache 2%
  • Dizziness 5%
  • Nausea and vomiting 1%
  • Difficulty controlling movements 4%
  • Lightheadedness 4%
More triazolam side effects »

We haven’t found good data for Restoril side effects.

FDA side effect reports for Restoril »

The oxazepam FDA package insert doesn’t have numbers about how common side effects are.

More about oxazepam side effects »
How it works
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
Librium (chlordiazepoxide) is a benzodiazepine. It's not clear how Librium (chlordiazepoxide) treats anxiety, but it possibly calms activity in a part of the brain that's responsible for emotional responses.Xanax (Alprazolam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Halcion (triazolam) is a benzodiazepine. It helps you stay asleep by extending how long you stay asleep, and improving the quality of your sleep so you don't wake up as much at night.Restoril (Temazepam) is a benzodiazepine. It affects chemicals in the brain to calm down your nervous system, helping you sleep and be less anxious.Serax (oxazepam) is a benzodiazepine. It binds to certain parts of nerves called GABA receptors, and stops the spread of signals that cause anxiety symptoms, or seizures in alcohol withdrawal.
Type of medication
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Pill
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
Used for
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
Risk factors for serious side effects
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Taking Librium (chlordiazepoxide) for more than 2 weeks
  • Drinking alcohol or taking narcotics
Detailed Librium (chlordiazepoxide) risks & warnings »
  • History of drug abuse
  • Taking with alcohol or drugs
  • Taking more than 4 mg/day or longer than 12 weeks
  • Stopping Xanax (Alprazolam) suddenly
  • Severely depressed
Detailed Xanax (alprazolam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Valium (diazepam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Ativan (lorazepam) risks & warnings »
  • Using Halcion (triazolam) for more than 10 days
  • People age 65 or older
  • Drinking alcohol
  • Not allowing enough time for sleep
Detailed Halcion (triazolam) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Women of childbearing age
Detailed Restoril (temazepam) risks & warnings »
  • Taking opioids
  • People age 65 or older
  • High blood pressure
Detailed Serax (oxazepam) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
No interactions related info.No interactions related info.No interactions related info.
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
No interactions related info.No interactions related info.No interactions related info.
Alcohol
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Don't drink alcohol or take any narcotics while taking Librium (chlordiazepoxide) since it can slow your breathing.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
  • Don't drink alcohol while taking Halcion (triazolam) since it can slow your breathing.
  • It is not safe to drink alcohol while taking this.
  • Serax (oxazepam) is a first choice medicine to treat seizures that can happen in alcohol withdrawal.
Kidneys and liver
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
No kidneys and liver related info.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Processed by the liver, so might not be the best choice if you have liver problems.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
Sleep
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
No sleep related info.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
  • People taking Halcion (triazolam) for sleep while fighting jet lag have reported not being able to remember what happened a few hours after taking the medicine. This is more likely to happen if you drink alcohol, or if you don't have enough time to sleep. Give yourself at least 7 to 8 hours to sleep to stop this from happening.
  • Shouldn't make you drowsy the next day as long as you're using normal doses of it.
  • Can cause dizziness and drowsiness, so don't do anything (like driving) after taking it that requires you to focus.
  • Restoril (Temazepam) can make you dizzy and drowsy, especially when combined with alcohol and many other medicines that acts in your brain. It is not recommended for people age 65 years or older.
No sleep related info.
Upsides and benefits
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Librium (chlordiazepoxide) is available as a generic.
  • Because Librium (chlordiazepoxide) lasts longer in the body, it's preferred for alcohol withdrawal since it's less likely to cause seizures.
  • Librium (chlordiazepoxide) can be used by itself, or with antidepressants to help lower anxiety.
  • Effective at relieving short-term anxiety.
  • Effective longer-term for panic attacks.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving muscle spasms caused by a variety of conditions.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
  • Halcion (triazolam) is available as a generic.
  • Compared to other similar medicines, you're less likely to have a hangover effect from Halcion (triazolam) the next day.
  • Helps you fall asleep and stay asleep.
  • Can be helpful to reduce anxiety.
  • Shouldn't make you drowsy the next day as long as you're using normal doses of it.
  • Serax (oxazepam) is a first choice medicine to treat seizures that can happen in alcohol withdrawal.
  • Serax (oxazepam) only lasts for a short time, so there's little risk of hangover effects or sleepiness.
  • Serax (oxazepam) is recommended for people who have advanced liver disease because it doesn't affect the liver.
Downsides and risks
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Librium (chlordiazepoxide) lasts much longer in older people, so it's not safe to use if you're age 65 or older.
  • Librium (chlordiazepoxide) is not as strong as similar medicines, so it's only really useful to calm anxiety and for alcohol withdrawal.
  • Librium (chlordiazepoxide) can be addictive, so you should use it for as short of a time as possible.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
  • Most people find that it gets less effective over time.
  • Your body can get used to Halcion (triazolam) after 2 weeks.
  • Stopping Halcion (triazolam) suddenly can make your insomnia worse. Talk to your doctor if you want to stop taking it.
  • People who take Halcion (triazolam) can have more anxiety during the day.
  • Can be habit-forming, meaning you'll start to rely on Restoril (Temazepam) to sleep.
  • Your body can get used to Restoril (Temazepam) and it may not work as well long-term.
  • It's not recommended for people age 65 years or older.
  • Can't be used by pregnant women since it'll cause harm to the baby.
  • If it's used everyday for more than 2 to 4 weeks and you decide to stop taking Restoril (Temazepam), you'll need to work with your doctor to slowly get off the drug to avoid extra side effects.
  • Serax (oxazepam) is addictive, so its use for anxiety should be limited to the shortest time possible.
Tips from our pharmacists for people taking the medication
chlordiazepoxideXanaxValiumAtivantriazolamRestoriloxazepam
  • Don't drink alcohol or take any narcotics while taking Librium (chlordiazepoxide) since it can slow your breathing.
  • You should take Librium (chlordiazepoxide) for as short amount of time as possible to treat your anxiety. Librium (chlordiazepoxide) can be addictive.
  • If you've taken Librium (chlordiazepoxide) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Librium (chlordiazepoxide) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 45 minutes when swallowed.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 30 minutes when swallowed.
  • Helpful with muscle spasms.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 45 minutes when swallowed.
  • Starts working in 10 to 20 minutes when dissolved under your tongue.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
  • Take Halcion (triazolam) on an empty stomach; otherwise, it won't work as well.
  • Don't drink alcohol while taking Halcion (triazolam) since it can slow your breathing.
  • You should only use Halcion (triazolam) for 7 to10 days. If it doesn't help you sleep, talk to your doctor.
  • You might have a hangover-like feeling the next day after taking Halcion (triazolam). Be careful driving or doing anything requiring concentration until you know how your body reacts to it.
  • Only take Halcion (triazolam) if you know you're going to bed right away.
  • Use only as needed when you can't sleep.
  • Starts working within 45 minutes.
  • Can cause dizziness and drowsiness, so don't do anything (like driving) after taking it that requires you to focus.
  • Take it only if you can get a full night's rest.
  • It is not safe to drink alcohol while taking this.
  • Tell your doctor if you notice any changes to your memory or mood.
  • Take Serax (oxazepam) exactly as your doctor tells you.
  • If you forget a dose, take it as soon as you remember; unless it's been more than 1 hour, then skip that dose and take Serax (oxazepam) at the next scheduled time. Don't take extra medicine to make up for the missed dose.
  • Don't drive or do anything requiring concentration until you know how Serax (oxazepam) affects you since it can make you sleepy. Drinking alcohol can make the sleepiness worse.
  • Serax (oxazepam) for anxiety is only good for 4 months. Talk to your doctor if you're still having anxiety and Serax (oxazepam) hasn't helped.
Learn more
More about chlordiazepoxideSide effectsAlternativesFDA package insert
Have you used Librium (chlordiazepoxide)?
Worth itNot sureNot worth it
More about XanaxSide effectsReviews & ratingsFDA package insert
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it
More about ValiumSide effectsReviews & ratingsFDA package insert
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
More about AtivanSide effectsReviews & ratingsFDA package insert
Have you used Ativan (lorazepam)?
Worth itNot sureNot worth it
More about triazolamSide effectsFDA package insert
Have you used Halcion (triazolam)?
Worth itNot sureNot worth it
More about RestorilSide effectsReviews & ratingsFDA package insert
Have you used Restoril (temazepam)?
Worth itNot sureNot worth it
More about oxazepamSide effectsFDA package insert
Have you used Serax (oxazepam)?
Worth itNot sureNot worth it